Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo

por Nieto-Rostro, Manuela, Ramgoolam, Krishma, Pratt, Wendy S., Kulik, Akos, Dolphin, Annette C.
Publicado 2018

The Interplay Between Splicing of Two Exon Combinations Differentially Affects Membrane Targeting and Function of Human Ca(V)2.2

por Dahimene, Shehrazade, Page, Karen M, Nieto-Rostro, Manuela, Pratt, Wendy S, Dolphin, Annette C
Publicado 2023

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits

por Dresviannikov, Andriy V., Page, Karen M., Leroy, Jerôme, Pratt, Wendy S., Dolphin, Annette C.
Publicado 2008

T-type Ca(2+) and persistent Na(+) currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability

por Topczewska, Aleksandra, Giacalone, Elisabetta, Pratt, Wendy S., Migliore, Michele, Dolphin, Annette C., Shah, Mala M.
Publicado 2023

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

por Heyes, Samuel, Pratt, Wendy S., Rees, Elliott, Dahimene, Shehrazade, Ferron, Laurent, Owen, Michael J., Dolphin, Annette C.
Publicado 2015

A Ca(V)2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant

por Dahimene, Shehrazade, Page, Karen M., Nieto-Rostro, Manuela, Pratt, Wendy S., D'Arco, Marianna, Dolphin, Annette C.
Publicado 2016

N Terminus Is Key to the Dominant Negative Suppression of Ca(V)2 Calcium Channels: IMPLICATIONS FOR EPISODIC ATAXIA TYPE 2

por Page, Karen M., Heblich, Fay, Margas, Wojciech, Pratt, Wendy S., Nieto-Rostro, Manuela, Chaggar, Kanchan, Sandhu, Kieran, Davies, Anthony, Dolphin, Annette C.
Publicado 2010

The α(2)δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α(2)δ-1

por Dahimene, Shehrazade, Page, Karen M., Kadurin, Ivan, Ferron, Laurent, Ho, Dominique Y., Powell, Gareth T., Pratt, Wendy S., Wilson, Stephen W., Dolphin, Annette C.
Publicado 2018

Calcium Currents Are Enhanced by α(2)δ-1 Lacking Its Membrane Anchor

por Kadurin, Ivan, Alvarez-Laviada, Anita, Ng, Shu Fun Josephine, Walker-Gray, Ryan, D'Arco, Marianna, Fadel, Michael G., Pratt, Wendy S., Dolphin, Annette C.
Publicado 2012

Differential upregulation in DRG neurons of an α(2)δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

por Lana, Beatrice, Schlick, Bettina, Martin, Stuart, Pratt, Wendy S., Page, Karen M., Goncalves, Leonor, Rahman, Wahida, Dickenson, Anthony H., Bauer, Claudia S., Dolphin, Annette C.
Publicado 2014

Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

por Kadurin, Ivan, Ferron, Laurent, Rothwell, Simon W, Meyer, James O, Douglas, Leon R, Bauer, Claudia S, Lana, Beatrice, Margas, Wojciech, Alexopoulos, Orpheas, Nieto-Rostro, Manuela, Pratt, Wendy S, Dolphin, Annette C
Publicado 2016

Disruption of the Key Ca(2+) Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking

por Meyer, James O., Dahimene, Shehrazade, Page, Karen M., Ferron, Laurent, Kadurin, Ivan, Ellaway, Joseph I.J., Zhao, Pengxiang, Patel, Tarun, Rothwell, Simon W., Lin, Peipeng, Pratt, Wendy S., Dolphin, Annette C.
Publicado 2019

Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy

por Dahimene, Shehrazade, von Elsner, Leonie, Holling, Tess, Mattas, Lauren S, Pickard, Jess, Lessel, Davor, Pilch, Kjara S, Kadurin, Ivan, Pratt, Wendy S, Zhulin, Igor B, Dai, Hongzheng, Hempel, Maja, Ruzhnikov, Maura R Z, Kutsche, Kerstin, Dolphin, Annette C
Publicado 2022