Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides

por Kohoutova, Zuzana, Malinak, David, Andrys, Rudolf, Svobodova, Jana, Psotka, Miroslav, Schmidt, Monika, Prchal, Lukas, Musilek, Kamil
Publicado 2022

Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation

por Zajíčková, Markéta, Prchal, Lukáš, Navrátilová, Martina, Vodvárková, Nikola, Matoušková, Petra, Vokřál, Ivan, Nguyen, Linh Thuy, Skálová, Lenka
Publicado 2021

The Antibacterial Effects of New N-Alkylpyridinium Salts on Planktonic and Biofilm Bacteria

por Hympanova, Michaela, Terlep, Saša, Markova, Aneta, Prchal, Lukáš, Dogsa, Iztok, Pulkrabkova, Lenka, Benkova, Marketa, Marek, Jan, Stopar, David
Publicado 2020

Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts

por Markova, Aneta, Hympanova, Michaela, Matula, Marek, Prchal, Lukas, Sleha, Radek, Benkova, Marketa, Pulkrabkova, Lenka, Soukup, Ondrej, Krocova, Zuzana, Jun, Daniel, Marek, Jan
Publicado 2021

Wide-Antimicrobial Spectrum of Picolinium Salts

por Salajkova, Sarka, Benkova, Marketa, Marek, Jan, Sleha, Radek, Prchal, Lukas, Malinak, David, Dolezal, Rafael, Sepčić, Kristina, Gunde-Cimerman, Nina, Kuca, Kamil, Soukup, Ondrej
Publicado 2020

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation

por Zajíčková, Markéta, Prchal, Lukáš, Vokřál, Ivan, Nguyen, Linh Thuy, Kurz, Thomas, Gasser, Robin, Bednářová, Klára, Mičundová, Magdalena, Lungerich, Beate, Michel, Oliver, Skálová, Lenka
Publicado 2022

The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods

por Salajkova, Sarka, Havel, Filip, Sramek, Michal, Novotny, Filip, Malinak, David, Dolezal, Rafael, Prchal, Lukas, Benkova, Marketa, Soukup, Ondrej, Musilek, Kamil, Kuca, Kamil, Bartek, Jiri, Proska, Jan, Zarska, Monika, Hodny, Zdenek
Publicado 2021

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D(2) 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole

por Juza, Radomir, Stefkova, Kristyna, Dehaen, Wim, Randakova, Alena, Petrasek, Tomas, Vojtechova, Iveta, Kobrlova, Tereza, Pulkrabkova, Lenka, Muckova, Lubica, Mecava, Marko, Prchal, Lukas, Mezeiova, Eva, Musilek, Kamil, Soukup, Ondrej, Korabecny, Jan
Publicado 2021

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric My...

por Bures, Jan, Tacheci, Ilja, Kvetina, Jaroslav, Radochova, Vera, Prchal, Lukas, Kohoutova, Darina, Valis, Martin, Novak, Martin, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Sestak, Vit, Knoblochova, Veronika, Peterova, Eva, Zdarova Karasova, Jana
Publicado 2021

Substituted Piperazines as Novel Potential Radioprotective Agents

por Filipova, Alzbeta, Marek, Jan, Havelek, Radim, Pejchal, Jaroslav, Jelicova, Marcela, Cizkova, Jana, Majorosova, Martina, Muckova, Lubica, Kucera, Tomas, Prchal, Lukas, Psotka, Miroslav, Zivna, Natalie, Koutova, Darja, Sinkorova, Zuzana, Rezacova, Martina, Tichy, Ales
Publicado 2020

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists

por Konecny, Jan, Misiachna, Anna, Hrabinova, Martina, Pulkrabkova, Lenka, Benkova, Marketa, Prchal, Lukas, Kucera, Tomas, Kobrlova, Tereza, Finger, Vladimir, Kolcheva, Marharyta, Kortus, Stepan, Jun, Daniel, Valko, Marian, Horak, Martin, Soukup, Ondrej, Korabecny, Jan
Publicado 2020

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

por Schmidt, Monika, Benek, Ondrej, Vinklarova, Lucie, Hrabinova, Martina, Zemanova, Lucie, Chribek, Matej, Kralova, Vendula, Hroch, Lukas, Dolezal, Rafael, Lycka, Antonin, Prchal, Lukas, Jun, Daniel, Aitken, Laura, Gunn-Moore, Frank, Kuca, Kamil, Musilek, Kamil
Publicado 2020

Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease

por Svobodova, Barbora, Pulkrabkova, Lenka, Panek, Dawid, Misiachna, Anna, Kolcheva, Marharyta, Andrys, Rudolf, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousar, Tomas, Prchal, Lukas, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Tosnerova, Daniela, Karabanovich, Galina, Finger, Vladimir, Soukup, Ondrej, Horak, Martin, Korabecny, Jan
Publicado 2023

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

por Rossi, Michele, Freschi, Michela, de Camargo Nascente, Luciana, Salerno, Alessandra, de Melo Viana Teixeira, Sarah, Nachon, Florian, Chantegreil, Fabien, Soukup, Ondrej, Prchal, Lukáš, Malaguti, Marco, Bergamini, Christian, Bartolini, Manuela, Angeloni, Cristina, Hrelia, Silvana, Soares Romeiro, Luiz Antonio, Bolognesi, Maria Laura
Publicado 2021