The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival

por Pfeiffer, S, Prehn, J H M
Publicado 2015

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicin...

por Würstle, M L, Zink, E, Prehn, J H M, Rehm, M
Publicado 2014

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

por Engel, T, Tanaka, K, Jimenez-Mateos, E M, Caballero-Caballero, A, Prehn, J H M, Henshall, D C
Publicado 2010

Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury

por Pfeiffer, S, Anilkumar, U, Chen, G, Ramírez-Peinado, S, Galindo-Moreno, J, Muñoz-Pinedo, C, Prehn, J H M
Publicado 2014

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus

por Bunk, E C, König, H-G, Bernas, T, Engel, T, Henshall, D C, Kirby, B P, Prehn, J H M
Publicado 2010

XIAP impairs Smac release from the mitochondria during apoptosis

por Flanagan, L, Sebastià, J, Tuffy, L P, Spring, A, Lichawska, A, Devocelle, M, Prehn, J H M, Rehm, M
Publicado 2010

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway

por Kögel, D, Reimertz, C, Mech, P, Poppe, M, Frühwald, M C, Engemann, H, Scheidtmann, K H, Prehn, J H M
Publicado 2001

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer

por Hector, S, Conlon, S, Schmid, J, Dicker, P, Cummins, R J, Concannon, C G, Johnston, P G, Kay, E W, Prehn, J H M
Publicado 2012

Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability

por Weisová, P, Alvarez, S P, Kilbride, S M, Anilkumar, U, Baumann, B, Jordán, J, Bernas, T, Huber, H J, Düssmann, H, Prehn, J H M
Publicado 2013

High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer

por Flanagan, L., Kehoe, J., Fay, J., Bacon, O., Lindner, A.U., Kay, E.W., Deasy, J., McNamara, D.A., Prehn, J.H.M.
Publicado 2015

Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

por Murphy, Á. C., Weyhenmeyer, B., Noonan, J., Kilbride, S. M., Schimansky, S., Loh, K. P., Kögel, D., Letai, A. G., Prehn, J. H. M., Murphy, B. M.
Publicado 2013

K(Ca)2 channels activation prevents [Ca(2+)](i) deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

por Dolga, A M, Terpolilli, N, Kepura, F, Nijholt, I M, Knaus, H-G, D'Orsi, B, Prehn, J H M, Eisel, U L M, Plant, T, Plesnila, N, Culmsee, C
Publicado 2011

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death

por Moran, C, Sanz-Rodriguez, A, Jimenez-Pacheco, A, Martinez-Villareal, J, McKiernan, R C, Jimenez-Mateos, E M, Mooney, C, Woods, I, Prehn, J H M, Henshall, D C, Engel, T
Publicado 2013

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach

por Flanagan, L, Meyer, M, Fay, J, Curry, S, Bacon, O, Duessmann, H, John, K, Boland, K C, McNamara, D A, Kay, E W, Bantel, H, Schulze-Bergkamen, H, Prehn, J H M
Publicado 2016

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

por Murphy, Á C, Weyhenmeyer, B, Schmid, J, Kilbride, S M, Rehm, M, Huber, H J, Senft, C, Weissenberger, J, Seifert, V, Dunst, M, Mittelbronn, M, Kögel, D, Prehn, J H M, Murphy, B M
Publicado 2013

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant

por Zakaria, Z, Tivnan, A, Flanagan, L, Murray, D W, Salvucci, M, Stringer, B W, Day, B W, Boyd, A W, Kögel, D, Rehm, M, O'Brien, D F, Byrne, A T, Prehn, J H M
Publicado 2016

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models

por Jarzabek, M A, Amberger-Murphy, V, Callanan, J J, Gao, C, Zagozdzon, A M, Shiels, L, Wang, J, Ligon, K L, Rich, B E, Dicker, P, Gallagher, W M, Prehn, J H M, Byrne, A T
Publicado 2014