T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

por Herbert, Katharine J., Ashton, Thomas M., Prevo, Remko, Pirovano, Giacomo, Higgins, Geoff S.
Publicado 2018

Depletion of signal recognition particle 72kDa increases radiosensitivity

por Prevo, Remko, Tiwana, Gaganpreet S., Maughan, Timothy S., Buffa, Francesca M., McKenna, W. Gillies, Higgins, Geoff S.
Publicado 2017

Automated 96-well format high throughput colony formation assay for siRNA library screen

por Hatch, Stephanie B., Prevo, Remko, Chan, Tiffany, Millar, Val, Cornelissen, Bart, Higgins, Geoff, Ebner, Daniel
Publicado 2022

Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

por Higgins, Geoff S, Harris, Adrian L, Prevo, Remko, Helleday, Thomas, McKenna, W Gillies, Buffa, Francesca M
Publicado 2010

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress

por Herbert, Katharine J., Puliyadi, Rathi, Prevo, Remko, Rodriguez-Berriguete, Gonzalo, Ryan, Anderson, Ramadan, Kristijan, Higgins, Geoff S.
Publicado 2020

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

por Fokas, Emmanouil, Yoshimura, Michio, Prevo, Remko, Higgins, Geoff, Hackl, Wolfgang, Maira, Sauveur-Michel, Bernhard, Eric J, McKenna, W Gillies, Muschel, Ruth J
Publicado 2012

The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

por Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.
Publicado 2020

Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity

por Rodriguez-Berriguete, Gonzalo, Granata, Giovanna, Puliyadi, Rathi, Tiwana, Gaganpreet, Prevo, Remko, Wilson, Rhodri S, Yu, Sheng, Buffa, Francesca, Humphrey, Timothy C, McKenna, W Gillies, Higgins, Geoff S
Publicado 2018

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

por Tiwana, Gaganpreet S., Prevo, Remko, Buffa, Francesca M., Yu, Sheng, Ebner, Daniel V., Howarth, Alison, Folkes, Lisa K., Budwal, Balam, Chu, Kwun-Ye, Durrant, Lisa, Muschel, Ruth J., McKenna, W. Gillies, Higgins, Geoff S.
Publicado 2015

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

por Pirovano, Giacomo, Ashton, Thomas M, Herbert, Katharine J, Bryant, Richard J, Verrill, Clare L, Cerundolo, Lucia, Buffa, Francesca M, Prevo, Remko, Harrap, Iona, Ryan, Anderson J, Macaulay, Valentine, McKenna, William G, Higgins, Geoff S
Publicado 2017

Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy

por Wu, Xiaoning, Scott, Helen, Carlsson, Sigrid V., Sjoberg, Daniel D., Cerundolo, Lucia, Lilja, Hans, Prevo, Remko, Rieunier, Guillaume, Macaulay, Valentine, Higgins, Geoffrey S., Verrill, Clare L., Lamb, Alastair D., Cunliffe, Vincent T., Bountra, Chas, Hamdy, Freddie C., Bryant, Richard J.
Publicado 2019

External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase

por Pokrovska, Tzveta D., Jacobus, Egon J., Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K., Champion, Brian R., Higgins, Geoff S., Seymour, Len W., Lei-Rossmann, Janet
Publicado 2020

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

por Rodriguez-Berriguete, Gonzalo, Ranzani, Marco, Prevo, Remko, Puliyadi, Rathi, Machado, Nicole, Bolland, Hannah R., Millar, Val, Ebner, Daniel, Boursier, Marie, Cerutti, Aurora, Cicconi, Alessandro, Galbiati, Alessandro, Grande, Diego, Grinkevich, Vera, Majithiya, Jayesh B., Piscitello, Desiree, Rajendra, Eeson, Stockley, Martin L., Boulton, Simon J., Hammond, Ester M., Heald, Robert A., Smith, Graeme C.M., Robinson, Helen M.R., Higgins, Geoff S.
Publicado 2023

Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma

por McGowan, Daniel R., Skwarski, Michael, Bradley, Kevin M., Campo, Leticia, Fenwick, John D., Gleeson, Fergus V., Green, Marcus, Horne, Amanda, Maughan, Timothy S., McCole, Mark G., Mohammed, Seid, Muschel, Ruth J., Ng, Stasya M., Panakis, Niki, Prevo, Remko, Strauss, Victoria Y., Stuart, Robert, Tacconi, Eliana M.C., Vallis, Katherine A., McKenna, W. Gillies, Macpherson, Ruth E., Higgins, Geoff S.
Publicado 2019

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

por Liao, Chunyan, Ashley, Neil, Diot, Alan, Morten, Karl, Phadwal, Kanchan, Williams, Andrew, Fearnley, Ian, Rosser, Lyndon, Lowndes, Jo, Fratter, Carl, Ferguson, David J.P., Vay, Laura, Quaghebeur, Gerardine, Moroni, Isabella, Bianchi, Stefania, Lamperti, Costanza, Downes, Susan M., Sitarz, Kamil S., Flannery, Padraig J., Carver, Janet, Dombi, Eszter, East, Daniel, Laura, Matilde, Reilly, Mary M., Mortiboys, Heather, Prevo, Remko, Campanella, Michelangelo, Daniels, Matthew J., Zeviani, Massimo, Yu-Wai-Man, Patrick, Simon, Anna Katharina, Votruba, Marcela, Poulton, Joanna
Publicado 2017

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

por Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.
Publicado 2021