High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

por Kleinstiver, Benjamin P., Pattanayak, Vikram, Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu, Zheng, Zongli, Joung, J. Keith
Publicado 2016

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

por Bloch, Noah B., Wales, Thomas E., Prew, Michelle S., Levy, Hannah R., Engen, John R., Walensky, Loren D.
Publicado 2021

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

por Kleinstiver, Benjamin P., Tsai, Shengdar Q., Prew, Michelle S., Nguyen, Nhu T., Welch, Moira M., Lopez, Jose M., McCaw, Zachary R., Aryee, Martin J., Joung, J. Keith
Publicado 2016

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

por Prew, Michelle S., Adhikary, Utsarga, Choi, Dong Wook, Portero, Erika P., Paulo, Joao A., Gowda, Pruthvi, Budhraja, Amit, Opferman, Joseph T., Gygi, Steven P., Danial, Nika N., Walensky, Loren D.
Publicado 2022

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

por Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved, Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P.W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith
Publicado 2015

Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer

por Cathcart, Ann M., Bird, Gregory H., Wales, Thomas E., Herce, Henry D., Harvey, Edward P., Hauseman, Zachary J., Newman, Catherine E., Adhikary, Utsarga, Prew, Michelle S., Oo, Tun, Lee, Susan, Engen, John R., Walensky, Loren D.
Publicado 2020

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

por Prew, Michelle S., Camara, Christina M., Botzanowski, Thomas, Moroco, Jamie A., Bloch, Noah B., Levy, Hannah R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Bird, Gregory H., Herce, Henry D., Gygi, Micah A., Escudero, Silvia, Wales, Thomas E., Engen, John R., Walensky, Loren D.
Publicado 2022

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

por Schmidts, Andrea, Marsh, Leah C, Srivastava, Ambike A, Bouffard, Amanda A, Boroughs, Angela C, Scarfò, Irene, Larson, Rebecca C, Bedoya, Felipe, Choi, Bryan D, Frigault, Matthew J, Bailey, Stefanie R, Leick, Mark B, Vatsa, Sonika, Kann, Michael C, Prew, Michelle S, Kleinstiver, Benjamin P, Joung, J Keith, Maus, Marcela V
Publicado 2020