Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice

por Baynard, Caroline, Prisinzano, Thomas E., Butelman, Eduardo R.
Publicado 2021

Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A

por Vasiljevik, Tamara, Groer, Chad E., Lehner, Kurt, Navarro, Hernan, Prisinzano, Thomas E.
Publicado 2014

Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model

por Zolkowska, Dorota, Andres-Mach, Marta, Prisinzano, Thomas E., Baumann, Michael H., Luszczki, Jarogniew J.
Publicado 2015

Sex Differences in Kappa Opioid Receptor Agonist Mediated Attenuation of Chemotherapy-Induced Neuropathic Pain in Mice

por Paton, Kelly F., Luo, Dan, La Flamme, Anne C., Prisinzano, Thomas E., Kivell, Bronwyn M.
Publicado 2022

A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans

por Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Jacobson, Arthur E., Rice, Kenner C.
Publicado 2023

Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues

por Riley, Andrew P., Groer, Chad E., Young, David, Ewald, Amy W., Kivell, Bronwyn M., Prisinzano, Thomas E.
Publicado 2014

Mitochondrial Targeted Coenzyme Q, Superoxide, and Fuel Selectivity in Endothelial Cells

por Fink, Brian D., O'Malley, Yunxia, Dake, Brian L., Ross, Nicolette C., Prisinzano, Thomas E., Sivitz, William I.
Publicado 2009

Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys

por Wakeford, Alison G P, Sherwood, Alexander M, Prisinzano, Thomas E, Bergman, Jack, Kohut, Stephen J, Paronis, Carol A
Publicado 2021

Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain

por Paton, Kelly F., Biggerstaff, Andrew, Kaska, Sophia, Crowley, Rachel S., La Flamme, Anne C., Prisinzano, Thomas E., Kivell, Bronwyn M.
Publicado 2020

Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease

por Denny, Lisa, Al Abadey, Afnan, Robichon, Katharina, Templeton, Nikki, Prisinzano, Thomas E, Kivell, Bronwyn M, La Flamme, Anne C
Publicado 2021

Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD

por Shelton, Catherine L., Meneely, Kathleen M., Ronnebaum, Trey A., Chilton, Annemarie S., Riley, Andrew P., Prisinzano, Thomas E., Lamb, Audrey L.
Publicado 2022

The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain

por Doss, Manoj K., May, Darrick G., Johnson, Matthew W., Clifton, John M., Hedrick, Sidnee L., Prisinzano, Thomas E., Griffiths, Roland R., Barrett, Frederick S.
Publicado 2020

Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents

por Kivell, Bronwyn M., Paton, Kelly F., Kumar, Nitin, Morani, Aashish S., Culverhouse, Aimee, Shepherd, Amy, Welsh, Susan A., Biggerstaff, Andrew, Crowley, Rachel S., Prisinzano, Thomas E.
Publicado 2018

The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis

por Paton, Kelly F., Robichon, Katharina, Templeton, Nikki, Denny, Lisa, Al Abadey, Afnan, Luo, Dan, Prisinzano, Thomas E., La Flamme, Anne C., Kivell, Bronwyn M.
Publicado 2021

Synthesis and Pharmacological Evaluation of Enantiopure N-Substituted Ortho-c Oxide-Bridged 5-Phenylmorphans

por Li, Fuying, Kopajtic, Theresa A., Katz, Jonathan L., Luo, Dan, Prisinzano, Thomas E., Imler, Gregory H., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Publicado 2022

The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depress...

por van de Wetering, Ross, Ewald, Amy, Welsh, Susan, Kornberger, Lindsay, Williamson, Samuel E., McElroy, Bryan D., Butelman, Eduardo R., Prisinzano, Thomas E., Kivell, Bronwyn M.
Publicado 2023

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

por Hedrick, Sidnee L., Luo, Dan, Kaska, Sophia, Niloy, Kumar Kulldeep, Jackson, Karen, Sarma, Rupam, Horn, Jamie, Baynard, Caroline, Leggas, Markos, Butelman, Eduardo R., Kreek, Mary Jeanne, Prisinzano, Thomas E.
Publicado 2021

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

por Lutz, Joshua A., Sulima, Agnieszka, Gutman, Eugene S., Bow, Eric W., Luo, Dan, Kaska, Sophia, Prisinzano, Thomas E., Paronis, Carol A., Bergman, Jack, Imler, Gregory H., Kerr, Andrew T., Jacobson, Arthur E., Rice, Kenner C.
Publicado 2023

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and...

por Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Goldberg, Alexander, Xie, Bing, Shi, Lei, Paronis, Carol A., Bergman, Jack, Nassehi, Nima, Selley, Dana E., Imler, Gregory H., Jacobson, Arthur E., Rice, Kenner C.
Publicado 2022

The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments

por Wang, Meining, Irvin, Thomas C., Herdman, Christine A., Hanna, Ramsey D., Hassan, Sergio A., Lee, Yong-Sok, Kaska, Sophia, Crowley, Rachel Saylor, Prisinzano, Thomas E., Withey, Sarah L., Paronis, Carol A., Bergman, Jack, Inan, Saadet, Geller, Ellen B., Adler, Martin W., Kopajtic, Theresa A., Katz, Jonathan L., Chadderdon, Aaron M., Traynor, John R., Jacobson, Arthur E., Rice, Kenner C.
Publicado 2020