Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

por Hepburn, Lydia A., McHugh, Angela, Fernandes, Kenneth, Boag, Garry, Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2018

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

por Roth, Kevin, Coussement, Louis, Knatko, Elena V., Higgins, Maureen, Steyaert, Sandra, Proby, Charlotte M., de Meyer, Tim, Dinkova-Kostova, Albena T.
Publicado 2021

Multimodal Transplant-clinic–based Skin Cancer Prevention Education for Organ Transplant Recipients: Feasibility Study

por Yu, Regina, Miura, Kyoko, Chambers, Daniel C., Hopkins, Peter M., Proby, Charlotte M., Bibee, Kristin, Plasmeijer, Elsemieke I., Green, Adele C.
Publicado 2023

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

por McHugh, Angela, Fernandes, Kenneth, South, Andrew P., Mellerio, Jemima E., Salas-Alanís, Julio C., Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2018

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mou...

por Kalin, Jay H., Eroglu, Abdulkerim, Liu, Hua, Holtzclaw, W. David, Leigh, Irene, Proby, Charlotte M., Fahey, Jed W., Cole, Philip A., Dinkova-Kostova, Albena T.
Publicado 2019

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

por McHugh, Angela, Fernandes, Kenneth, Chinner, Nerime, Ibrahim, Adel F.M., Garg, Amit K., Boag, Garry, Hepburn, Lydia A., Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2020

The Genomic Landscape of Actinic Keratosis

por Thomson, Jason, Bewicke-Copley, Findlay, Anene, Chinedu Anthony, Gulati, Abha, Nagano, Ai, Purdie, Karin, Inman, Gareth J., Proby, Charlotte M., Leigh, Irene M., Harwood, Catherine A., Wang, Jun
Publicado 2021

Genomic analysis of atypical fibroxanthoma

por Lai, Kevin, Harwood, Catherine A., Purdie, Karin J., Proby, Charlotte M., Leigh, Irene M., Ravi, Namita, Mully, Thaddeus W., Brooks, Lionel, Sandoval, Priscilla M., Rosenblum, Michael D., Arron, Sarah T.
Publicado 2017

The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare

por Harkins, Catriona P., Pettigrew, Kerry A., Oravcová, Katarina, Gardner, June, Hearn, R.M. Ross, Rice, Debbie, Mather, Alison E., Parkhill, Julian, Brown, Sara J., Proby, Charlotte M., Holden, Matthew T.G.
Publicado 2018

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

por Purdie, Karin J., Proby, Charlotte M., Rizvi, Hasan, Griffin, Heather, Doorbar, John, Sommerlad, Mary, Feltkamp, Mariet C., der Meijden, Els Van, Inman, Gareth J., South, Andrew P., Leigh, Irene M., Harwood, Catherine A.
Publicado 2018

MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma

por Olasz, Edit B., Seline, Lauren N., Schock, Ashley M., Duncan, Nathan E., Lopez, Argelia, Lazar, Jozef, Flister, Michael J., Lu, Yan, Liu, Pengyuan, Sokumbi, Olayemi, Harwood, Catherine A., Proby, Charlotte M., Neuburg, Marcy, Lazarova, Zelmira
Publicado 2015

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

por Hassan, Sakinah, Purdie, Karin J., Wang, Jun, Harwood, Catherine A., Proby, Charlotte M., Pourreyron, Celine, Mladkova, Nikol, Nagano, Ai, Dhayade, Sandeep, Athineos, Dimitris, Caley, Matthew, Mannella, Viviana, Blyth, Karen, Inman, Gareth J., Leigh, Irene M.
Publicado 2019

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

por Rose, Aidan M., Spender, Lindsay C., Stephen, Christopher, Mitchell, Alastair, Rickaby, William, Bray, Susan, Evans, Alan T., Dayal, Jasbani, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M., Coates, Philip J., Inman, Gareth J.
Publicado 2018

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

por Matin, Rubeta N., Chikh, Anissa, Law Pak Chong, Stephanie, Mesher, David, Graf, Manuela, Sanza’, Paolo, Senatore, Valentina, Scatolini, Maria, Moretti, Francesca, Leigh, Irene M., Proby, Charlotte M., Costanzo, Antonio, Chiorino, Giovanna, Cerio, Rino, Harwood, Catherine A., Bergamaschi, Daniele
Publicado 2013

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

por Inman, Gareth J., Wang, Jun, Nagano, Ai, Alexandrov, Ludmil B., Purdie, Karin J., Taylor, Richard G., Sherwood, Victoria, Thomson, Jason, Hogan, Sarah, Spender, Lindsay C., South, Andrew P., Stratton, Michael, Chelala, Claude, Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M.
Publicado 2018

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

por South, Andrew P, Purdie, Karin J, Watt, Stephen A, Haldenby, Sam, den Breems, Nicoline, Dimon, Michelle, Arron, Sarah T, Kluk, Michael J, Aster, Jon C, McHugh, Angela, Xue, Dylan J, Dayal, Jasbani HS, Robinson, Kim S, Rizvi, SM Hasan, Proby, Charlotte M, Harwood, Catherine A, Leigh, Irene M
Publicado 2014

Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression

por Li Mow Chee, Frederic, Beernaert, Bruno, Griffith, Billie G. C., Loftus, Alexander E. P., Kumar, Yatendra, Wills, Jimi C., Lee, Martin, Valli, Jessica, Wheeler, Ann P., Armstrong, J. Douglas, Parsons, Maddy, Leigh, Irene M., Proby, Charlotte M., von Kriegsheim, Alex, Bickmore, Wendy A., Frame, Margaret C., Byron, Adam
Publicado 2023

Topical treatment of actinic keratoses in organ transplant recipients: a feasibility study for SPOT (Squamous cell carcinoma Prevention in Organ transplant recipients using Topical...

por Hasan, Zeeshaan‐Ul, Ahmed, Ikhlaaq, Matin, Rubeta N., Homer, Victoria, Lear, John T., Ismail, Ferina, Whitmarsh, Tristan, Green, Adele C., Thomson, Jason, Milligan, Alan, Hogan, Sarah, Van‐de‐Velde, Vanessa, Mitchell‐Worsford, Liza, Kentley, Jonathan, Gaunt, Claire, Jefferson‐Hulme, Yolande, Bowden, Sarah J., Gaunt, Piers, Wheatley, Keith, Proby, Charlotte M., Harwood, Catherine A.
Publicado 2022

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

por Bailey, Peter, Ridgway, Rachel A., Cammareri, Patrizia, Treanor-Taylor, Mairi, Bailey, Ulla-Maja, Schoenherr, Christina, Bone, Max, Schreyer, Daniel, Purdie, Karin, Thomson, Jason, Rickaby, William, Jackstadt, Rene, Campbell, Andrew D., Dimonitsas, Emmanouil, Stratigos, Alexander J., Arron, Sarah T., Wang, Jun, Blyth, Karen, Proby, Charlotte M., Harwood, Catherine A., Sansom, Owen J., Leigh, Irene M., Inman, Gareth J.
Publicado 2023

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

por Cammareri, Patrizia, Rose, Aidan M., Vincent, David F., Wang, Jun, Nagano, Ai, Libertini, Silvana, Ridgway, Rachel A., Athineos, Dimitris, Coates, Philip J., McHugh, Angela, Pourreyron, Celine, Dayal, Jasbani H. S., Larsson, Jonas, Weidlich, Simone, Spender, Lindsay C., Sapkota, Gopal P., Purdie, Karin J., Proby, Charlotte M., Harwood, Catherine A., Leigh, Irene M., Clevers, Hans, Barker, Nick, Karlsson, Stefan, Pritchard, Catrin, Marais, Richard, Chelala, Claude, South, Andrew P., Sansom, Owen J., Inman, Gareth J.
Publicado 2016