The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer

por He, Suqin, Smith, Donald L., Sequeira, Manuel, Sang, Jim, Bates, Richard C., Proia, David A.
Publicado 2014

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition

por Gomez-Casal, Roberto, Epperly, Michael W., Wang, Hong, Proia, David A., Greenberger, Joel S., Levina, Vera
Publicado 2015

Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes

por Friedland, Julie C., Smith, Donald L., Sang, Jim, Acquaviva, Jaime, He, Suqin, Zhang, Chaohua, Proia, David A.
Publicado 2013

The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer

por Smith, Donald L., Acquaviva, Jaime, Sequeira, Manuel, Jimenez, John-Paul, Zhang, Chaohua, Sang, Jim, Bates, Richard C., Proia, David A.
Publicado 2014

STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma

por Heske, Christine M., Mendoza, Arnulfo, Edessa, Leah D., Baumgart, Joshua T., Lee, Sunmin, Trepel, Jane, Proia, David A., Neckers, Len, Helman, Lee J.
Publicado 2016

Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

por Smithline, Zachary B., Nikonova, Anna S., Hensley, Harvey H., Cai, Kathy Q., Egleston, Brian L., Proia, David A., Seeger-Nukpezah, Tamina, Golemis, Erica A.
Publicado 2014

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

por Gomez-Casal, Roberto, Bhattacharya, Chitralekha, Epperly, Michael W., Basse, Per H., Wang, Hong, Wang, Xinhui, Proia, David A., Greenberger, Joel S., Socinski, Mark A., Levina, Vera
Publicado 2015

Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models

por Bobrov, Egor, Skobeleva, Natalia, Restifo, Diana, Beglyarova, Natalya, Cai, Kathy Q., Handorf, Elizabeth, Campbell, Kerry, Proia, David A., Khazak, Vladimir, Golemis, Erica A., Astsaturov, Igor
Publicado 2016

Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

por HE, SUQIN, ZHANG, CHAOHUA, SHAFI, AYESHA A., SEQUEIRA, MANUEL, ACQUAVIVA, JAIME, FRIEDLAND, JULIE C., SANG, JIM, SMITH, DONALD L., WEIGEL, NANCY L., WADA, YUMIKO, PROIA, DAVID A.
Publicado 2012

Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

por Proia, David A., Foley, Kevin P., Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C., Liu, Yuan, Rosenberg, Alex F., Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K.
Publicado 2011

Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

por Blackman, Ronald K., Cheung-Ong, Kahlin, Gebbia, Marinella, Proia, David A., He, Suqin, Kepros, Jane, Jonneaux, Aurelie, Marchetti, Philippe, Kluza, Jerome, Rao, Patricia E., Wada, Yumiko, Giaever, Guri, Nislow, Corey
Publicado 2012

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models

por Proia, David A., Sang, Jim, He, Suqin, Smith, Donald L., Sequeira, Manuel, Zhang, Chaohua, Liu, Yuan, Ye, Shuxia, Zhou, Dan, Blackman, Ronald K., Foley, Kevin P., Koya, Keizo, Wada, Yumiko
Publicado 2012

Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

por Sun, Danlin, Nikonova, Anna S., Zhang, Peishan, Deneka, Alexander Y., Fitzgerald, Mark E., Michael, Ryan E., Lee, Linda, Lilly, Anna C., Fisher, Stewart L., Phillips, Andrew J., Nasveschuk, Christopher G., Proia, David A., Tu, Zhigang, Golemis, Erica A.
Publicado 2021

High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer

por Jansson, Keith H., Tucker, John B., Stahl, Lauren E., Simmons, John K., Fuller, Caitlyn, Beshiri, Michael L., Agarwal, Supreet, Fang, Lei, Hynes, Paul G., Alilin, Aian Neil, Lake, Ross, Abbey, Yasmine C., Cawley, Jacob, Tice, Caitlin M., Yin, JuanJuan, McKnight, Crystal, Klummp-Thomas, Carleen, Zhang, Xiaohu, Guha, Rajarshi, Hoover, Shelley, Simpson, R. Mark, Nguyen, Holly M., Corey, Eva, Thomas, Craig J., Proia, David A., Kelly, Kathleen
Publicado 2018