Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

por Prudencio, Mercedes, Borchelt, David R
Publicado 2011

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

por Prudencio, Mercedes, Durazo, Armando, Whitelegge, Julian P., Borchelt, David R.
Publicado 2010

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

por Prudencio, Mercedes, Hart, P. John, Borchelt, David R., Andersen, Peter M.
Publicado 2009

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1

por Qualls, David A, Prudencio, Mercedes, Roberts, Brittany LT, Crosby, Keith, Brown, Hilda, Borchelt, David R
Publicado 2013

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

por Goodman, Lindsey D., Prudencio, Mercedes, Srinivasan, Ananth R., Rifai, Olivia M., Lee, Virginia M.-Y., Petrucelli, Leonard, Bonini, Nancy M.
Publicado 2019

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43

por Xu, Ya-Fei, Prudencio, Mercedes, Hubbard, Jaime M., Tong, Jimei, Whitelaw, Ena C., Jansen-West, Karen, Stetler, Caroline, Cao, Xiangkun, Song, John, Zhang, Yong-Jie
Publicado 2013

Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood

por Melnick, Marko, Gonzales, Patrick, LaRocca, Thomas J, Song, Yuping, Wuu, Joanne, Benatar, Michael, Oskarsson, Björn, Petrucelli, Leonard, Dowell, Robin D, Link, Christopher D, Prudencio, Mercedes
Publicado 2021

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

por Mordes, Daniel A., Prudencio, Mercedes, Goodman, Lindsey D., Klim, Joseph R., Moccia, Rob, Limone, Francesco, Pietilainen, Olli, Chowdhary, Kaitavjeet, Dickson, Dennis W., Rademakers, Rosa, Bonini, Nancy M., Petrucelli, Leonard, Eggan, Kevin
Publicado 2018

Race affects adverse outcomes of deep vein thrombosis, pulmonary embolism, and acute kidney injury in coronavirus disease 2019 hospitalized patients

por Erben, Young, Marquez, Christopher P., Prudencio, Mercedes, Fortich, Susana, Gendron, Tania, Sanghavi, Devang, Hickson, LaTonya, Li, Yupeng, Edwards, Michael A., Ritchie, Charles, Franco, Pablo Moreno, Petrucelli, Leonard, Meschia, James F.
Publicado 2023

The lysosomal protein cathepsin L is a progranulin protease

por Lee, Chris W., Stankowski, Jeannette N., Chew, Jeannie, Cook, Casey N., Lam, Ying-Wai, Almeida, Sandra, Carlomagno, Yari, Lau, Kwok-Fai, Prudencio, Mercedes, Gao, Fen-Biao, Bogyo, Matthew, Dickson, Dennis W., Petrucelli, Leonard
Publicado 2017

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

por Koike, Yuka, Pickles, Sarah, Estades Ayuso, Virginia, Jansen-West, Karen, Qi, Yue A., Li, Ziyi, Daughrity, Lillian M., Yue, Mei, Zhang, Yong-Jie, Cook, Casey N., Dickson, Dennis W., Ward, Michael, Petrucelli, Leonard, Prudencio, Mercedes
Publicado 2023

Correction: TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

por Koike, Yuka, Pickles, Sarah, Ayuso, Virginia Estades, Jansen-West, Karen, Qi, Yue A., Li, Ziyi, Daughrity, Lillian M., Yue, Mei, Zhang, Yong-Jie, Cook, Casey N., Dickson, Dennis W., Ward, Michael, Petrucelli, Leonard, Prudencio, Mercedes
Publicado 2023

Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

por Belzil, Veronique V., Bauer, Peter O., Prudencio, Mercedes, Gendron, Tania F., Stetler, Caroline T., Yan, Irene K., Pregent, Luc, Daughrity, Lillian, Baker, Matthew C., Rademakers, Rosa, Boylan, Kevin, Patel, Tushar C., Dickson, Dennis W., Petrucelli, Leonard
Publicado 2013

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

por Wu, Yanwei, Shao, Wei, Todd, Tiffany W., Tong, Jimei, Yue, Mei, Koga, Shunsuke, Castanedes-Casey, Monica, Librero, Ariston L., Lee, Chris W., Mackenzie, Ian R., Dickson, Dennis W., Zhang, Yong-Jie, Petrucelli, Leonard, Prudencio, Mercedes
Publicado 2021

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

por Goodman, Lindsey D., Prudencio, Mercedes, Kramer, Nicholas J., Martinez-Ramirez, Luis F., Srinivasan, Ananth R., Lan, Matthews, Parisi, Michael J., Zhu, Yongqing, Chew, Jeannie, Cook, Casey N., Berson, Amit, Gitler, Aaron D., Petrucelli, Leonard, Bonini, Nancy M.
Publicado 2019

Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

por Jackson, Jazmyne L., Finch, NiCole A., Baker, Matthew C., Kachergus, Jennifer M., DeJesus-Hernandez, Mariely, Pereira, Kimberly, Christopher, Elizabeth, Prudencio, Mercedes, Heckman, Michael G., Thompson, E. Aubrey, Dickson, Dennis W., Shah, Jaimin, Oskarsson, Björn, Petrucelli, Leonard, Rademakers, Rosa, van Blitterswijk, Marka
Publicado 2020

Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model

por Jansen-West, Karen, Todd, Tiffany W., Daughrity, Lillian M., Yue, Mei, Tong, Jimei, Carlomagno, Yari, Del Rosso, Giulia, Kurti, Aishe, Jones, Caroline Y., Dunmore, Judith A., Castanedes-Casey, Monica, Dickson, Dennis W., Wszolek, Zbigniew K., Fryer, John D., Petrucelli, Leonard, Prudencio, Mercedes
Publicado 2022

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

por Estades Ayuso, Virginia, Pickles, Sarah, Todd, Tiffany, Yue, Mei, Jansen-West, Karen, Song, Yuping, González Bejarano, Jesús, Rawlinson, Bailey, DeTure, Michael, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Josephs, Keith A., Petrucelli, Leonard, Prudencio, Mercedes
Publicado 2023

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

por Lee, Wing C., Almeida, Sandra, Prudencio, Mercedes, Caulfield, Thomas R., Zhang, Yong-Jie, Tay, William M., Bauer, Peter O., Chew, Jeannie, Sasaguri, Hiroki, Jansen-West, Karen R., Gendron, Tania F., Stetler, Caroline T., Finch, NiCole, Mackenzie, Ian R., Rademakers, Rosa, Gao, Fen-Biao, Petrucelli, Leonard
Publicado 2014

Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD

por Krishnan, Gopinath, Raitcheva, Denitza, Bartlett, Daniel, Prudencio, Mercedes, McKenna-Yasek, Diane M., Douthwright, Catherine, Oskarsson, Björn E., Ladha, Shafeeq, King, Oliver D., Barmada, Sami J., Miller, Timothy M., Bowser, Robert, Watts, Jonathan K., Petrucelli, Leonard, Brown, Robert H., Kankel, Mark W., Gao, Fen-Biao
Publicado 2022