Nucleoside analogues for the treatment of coronavirus infections

por Pruijssers, Andrea J, Denison, Mark R
Publicado 2019

Bid Regulates the Pathogenesis of Neurotropic Reovirus

por Danthi, Pranav, Pruijssers, Andrea J., Berger, Angela K., Holm, Geoffrey H., Zinkel, Sandra S., Dermody, Terence S.
Publicado 2010

Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response

por Wu, Allen G., Pruijssers, Andrea J., Brown, Judy J., Stencel-Baerenwald, Jennifer E., Sutherland, Danica M., Iskarpatyoti, Jason A., Dermody, Terence S.
Publicado 2018

Evaluation of in vitro antiviral activity of SARS-CoV-2 M(pro) inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions

por Tong, Xiao, Keung, Walter, Arnold, Lee D., Stevens, Laura J., Pruijssers, Andrea J., Kook, Seunghyi, Lopatin, Uri, Denison, Mark, Kwong, Ann D.
Publicado 2023

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

por Gribble, Jennifer, Stevens, Laura J., Agostini, Maria L., Anderson-Daniels, Jordan, Chappell, James D., Lu, Xiaotao, Pruijssers, Andrea J., Routh, Andrew L., Denison, Mark R.
Publicado 2021

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

por Grimes, Samantha L., Choi, Young J., Banerjee, Anoosha, Small, Gabriel, Anderson-Daniels, Jordan, Gribble, Jennifer, Pruijssers, Andrea J., Agostini, Maria L., Abu-Shmais, Alexandra, Lu, Xiaotao, Darst, Seth A., Campbell, Elizabeth, Denison, Mark R.
Publicado 2023

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

por Goubau, Delphine, Schlee, Martin, Deddouche, Safia, Pruijssers, Andrea J., Zillinger, Thomas, Goldeck, Marion, Schuberth, Christine, Van der Veen, Annemarthe G., Fujimura, Tsutomu, Rehwinkel, Jan, Iskarpatyoti, Jason A., Barchet, Winfried, Ludwig, Janos, Dermody, Terence S., Hartmann, Gunther, Reis e Sousa, Caetano
Publicado 2014

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

por Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Publicado 2019

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

por Stevens, Laura J., Pruijssers, Andrea J., Lee, Hery W., Gordon, Calvin J., Tchesnokov, Egor P., Gribble, Jennifer, George, Amelia S., Hughes, Tia M., Lu, Xiaotao, Li, Jiani, Perry, Jason K., Porter, Danielle P., Cihlar, Tomas, Sheahan, Timothy P., Baric, Ralph S., Götte, Matthias, Denison, Mark R.
Publicado 2022

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

por Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.
Publicado 2020

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

por Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.
Publicado 2020

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

por Widge, Alicia T., Rouphael, Nadine G., Jackson, Lisa A., Anderson, Evan J., Roberts, Paul C., Makhene, Mamodikoe, Chappell, James D., Denison, Mark R., Stevens, Laura J., Pruijssers, Andrea J., McDermott, Adrian B., Flach, Britta, Lin, Bob C., Doria-Rose, Nicole A., O’Dell, Sijy, Schmidt, Stephen D., Neuzil, Kathleen M., Bennett, Hamilton, Leav, Brett, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Edara, Venkata-Viswanadh, Floyd, Katharine, Suthar, Mehul S., Buchanan, Wendy, Luke, Catherine J., Ledgerwood, Julie E., Mascola, John R., Graham, Barney S., Beigel, John H.
Publicado 2020

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

por Jackson, Lisa A., Anderson, Evan J., Rouphael, Nadine G., Roberts, Paul C., Makhene, Mamodikoe, Coler, Rhea N., McCullough, Michele P., Chappell, James D., Denison, Mark R., Stevens, Laura J., Pruijssers, Andrea J., McDermott, Adrian, Flach, Britta, Doria-Rose, Nicole A., Corbett, Kizzmekia S., Morabito, Kaitlyn M., O’Dell, Sijy, Schmidt, Stephen D., Swanson, Phillip A., Padilla, Marcelino, Mascola, John R., Neuzil, Kathleen M., Bennett, Hamilton, Sun, Wellington, Peters, Etza, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Buchanan, Wendy, Pikaart-Tautges, Rhonda, Ledgerwood, Julie E., Graham, Barney S., Beigel, John H.
Publicado 2020

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

por Anderson, Evan J., Rouphael, Nadine G., Widge, Alicia T., Jackson, Lisa A., Roberts, Paul C., Makhene, Mamodikoe, Chappell, James D., Denison, Mark R., Stevens, Laura J., Pruijssers, Andrea J., McDermott, Adrian B., Flach, Britta, Lin, Bob C., Doria-Rose, Nicole A., O’Dell, Sijy, Schmidt, Stephen D., Corbett, Kizzmekia S., Swanson, Phillip A., Padilla, Marcelino, Neuzil, Kathy M., Bennett, Hamilton, Leav, Brett, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Edara, Venkata Viswanadh, Floyd, Katharine, Suthar, Mehul S., Martinez, David R., Baric, Ralph, Buchanan, Wendy, Luke, Catherine J., Phadke, Varun K., Rostad, Christina A., Ledgerwood, Julie E., Graham, Barney S., Beigel, John H.
Publicado 2020

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

por Pegu, Amarendra, O’Connell, Sarah E., Schmidt, Stephen D., O’Dell, Sijy, Talana, Chloe A., Lai, Lilin, Albert, Jim, Anderson, Evan, Bennett, Hamilton, Corbett, Kizzmekia S., Flach, Britta, Jackson, Lisa, Leav, Brett, Ledgerwood, Julie E., Luke, Catherine J., Makowski, Mat, Nason, Martha C., Roberts, Paul C., Roederer, Mario, Rebolledo, Paulina A., Rostad, Christina A., Rouphael, Nadine G., Shi, Wei, Wang, Lingshu, Widge, Alicia T., Yang, Eun Sung, Beigel, John H., Graham, Barney S., Mascola, John R., Suthar, Mehul S., McDermott, Adrian B., Doria-Rose, Nicole A., Arega, Jae, Beigel, John H., Buchanan, Wendy, Elsafy, Mohammed, Hoang, Binh, Lampley, Rebecca, Kolhekar, Aparna, Koo, Hyung, Luke, Catherine, Makhene, Mamodikoe, Nayak, Seema, Pikaart-Tautges, Rhonda, Roberts, Paul C., Russell, Janie, Sindall, Elisa, Albert, Jim, Kunwar, Pratap, Makowski, Mat, Anderson, Evan J., Bechnak, Amer, Bower, Mary, Camacho-Gonzalez, Andres F., Collins, Matthew, Drobeniuc, Ana, Edara, Venkata Viswanadh, Edupuganti, Srilatha, Floyd, Katharine, Gibson, Theda, Ackerley, Cassie M. Grimsley, Johnson, Brandi, Kamidani, Satoshi, Kao, Carol, Kelley, Colleen, Lai, Lilin, Macenczak, Hollie, McCullough, Michele Paine, Peters, Etza, Phadke, Varun K., Rebolledo, Paulina A., Rostad, Christina A., Rouphael, Nadine, Scherer, Erin, Sherman, Amy, Stephens, Kathy, Suthar, Mehul S., Teherani, Mehgan, Traenkner, Jessica, Winston, Juton, Yildirim, Inci, Barr, Lee, Benoit, Joyce, Carste, Barbara, Choe, Joe, Dunstan, Maya, Erolin, Roxanne, ffitch, Jana, Fields, Colin, Jackson, Lisa A., Kiniry, Erika, Lasicka, Susan, Lee, Stella, Nguyen, Matthew, Pimienta, Stephanie, Suyehira, Janice, Witte, Michael, Bennett, Hamilton, Altaras, Nedim Emil, Carfi, Andrea, Hurley, Marjorie, Leav, Brett, Pajon, Rolando, Sun, Wellington, Zaks, Tal, Coler, Rhea N., Larsen, Sasha E., Neuzil, Kathleen M., Lindesmith, Lisa C., Martinez, David R., Munt, Jennifer, Mallory, Michael, Edwards, Caitlin, Baric, Ralph S., Berkowitz, Nina M., Boritz, Eli A., Carlton, Kevin, Corbett, Kizzmekia S., Costner, Pamela, Creanga, Adrian, Doria-Rose, Nicole A., Douek, Daniel C., Flach, Britta, Gaudinski, Martin, Gordon, Ingelise, Graham, Barney S., Holman, LaSonji, Ledgerwood, Julie E., Leung, Kwanyee, Lin, Bob C., Louder, Mark K., Mascola, John R., McDermott, Adrian B., Morabito, Kaitlyn M., Novik, Laura, O’Connell, Sarah, O’Dell, Sijy, Padilla, Marcelino, Pegu, Amarendra, Schmidt, Stephen D., Shi, Wei, Swanson, Phillip A., Talana, Chloe A., Wang, Lingshu, Widge, Alicia T., Yang, Eun Sung, Zhang, Yi, Chappell, James D., Denison, Mark R., Hughes, Tia, Lu, Xiaotao, Pruijssers, Andrea J., Stevens, Laura J., Posavad, Christine M., Gale, Michael, Menachery, Vineet, Shi, Pei-Yong
Publicado 2021