Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system

por Prysyazhna, Oleksandra, Eaton, Philip
Publicado 2015

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

por Prysyazhna, Oleksandra, Rudyk, Olena, Eaton, Philip
Publicado 2012

High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse

por Prysyazhna, Oleksandra, Rudyk, Olena, Eaton, Philip
Publicado 2011

Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation

por Prysyazhna, Oleksandra, Burgoyne, Joseph R, Eaton, Philip
Publicado 2015

Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension

por Rudyk, Olena, Prysyazhna, Oleksandra, Zhao, Lan, Eaton, Philip
Publicado 2015

Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

por Yogendran, Vaishaali, Mele, Laura, Prysyazhna, Oleksandra, Budhram-Mahadeo, Vishwanie S.
Publicado 2023

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)

por Burgoyne, Joseph R., Prysyazhna, Oleksandra, Richards, Daniel A., Eaton, Philip
Publicado 2017

Protein kinase G oxidation contribute to hypotension and organ injury during sepsis

por Rudyk, Olena, Phinikaridou, Alkystis, Prysyazhna, Oleksandra, Burgoyne, Joseph R, Botnar, Rene, Eaton, Philip
Publicado 2013

PKG1α oxidation negatively regulates food seeking behaviour and reward

por Duraffourd, Celine, Huckstepp, Robert T.R., Braren, Ingke, Fernandes, Cathy, Brock, Olivier, Delogu, Alessio, Prysyazhna, Oleksandra, Burgoyne, Joseph, Eaton, Philip
Publicado 2018

Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

por Prysyazhna, Oleksandra, Wolhuter, Kathryn, Switzer, Christopher, Santos, Celio, Yang, Xiaoping, Lynham, Steven, Shah, Ajay M., Eaton, Philip, Burgoyne, Joseph R.
Publicado 2019

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

por Mistry, Rajesh K., Murray, Thomas V. A., Prysyazhna, Oleksandra, Martin, Daniel, Burgoyne, Joseph R., Santos, Celio, Eaton, Philip, Shah, Ajay M., Brewer, Alison C.
Publicado 2016

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

por Rudyk, Olena, Rowan, Alice, Prysyazhna, Oleksandra, Krasemann, Susanne, Hartmann, Kristin, Zhang, Min, Shah, Ajay M., Ruppert, Clemens, Weiss, Astrid, Schermuly, Ralph T., Ida, Tomoaki, Akaike, Takaaki, Zhao, Lan, Eaton, Philip
Publicado 2019

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

por Fernandez-Caggiano, Mariana, Kamynina, Alisa, Francois, Asvi A., Prysyazhna, Oleksandra, Eykyn, Thomas R., Krasemann, Susanne, Crespo-Leiro, Maria G., Vieites, Maria Garcia, Bianchi, Katiuscia, Morales, Valle, Domenech, Nieves, Eaton, Philip
Publicado 2020

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling

por Feelisch, Martin, Akaike, Takaaki, Griffiths, Kayleigh, Ida, Tomoaki, Prysyazhna, Oleksandra, Goodwin, Joanna J, Gollop, Nicholas D, Fernandez, Bernadette O, Minnion, Magdalena, Cortese-Krott, Miriam M, Borgognone, Alessandra, Hayes, Rosie M, Eaton, Philip, Frenneaux, Michael P, Madhani, Melanie
Publicado 2020

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

por Scotcher, Jenna, Prysyazhna, Oleksandra, Boguslavskyi, Andrii, Kistamas, Kornel, Hadgraft, Natasha, Martin, Eva D., Worthington, Jenny, Rudyk, Olena, Rodriguez Cutillas, Pedro, Cuello, Friederike, Shattock, Michael J., Marber, Michael S., Conte, Maria R., Greenstein, Adam, Greensmith, David J., Venetucci, Luigi, Timms, John F., Eaton, Philip
Publicado 2016

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure

por Sag, Can Martin, Schnelle, Moritz, Zhang, Juqian, Murdoch, Colin E., Kossmann, Sabine, Protti, Andrea, Santos, Celio X.C., Sawyer, Greta, Zhang, Xiaohong, Mongue-Din, Heloise, Richards, Daniel A., Brewer, Alison C., Prysyazhna, Oleksandra, Maier, Lars S., Wenzel, Philip, Eaton, Philip J., Shah, Ajay M.
Publicado 2017

Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans

por Boguslavskyi, Andrii, Tokar, Sergiy, Prysyazhna, Oleksandra, Rudyk, Olena, Sanchez-Tatay, David, Lemmey, Hamish A.L., Dora, Kim A., Garland, Christopher J., Warren, Helen R., Doney, Alexander, Palmer, Colin N.A., Caulfield, Mark J., Vlachaki Walker, Julia, Howie, Jacqueline, Fuller, William, Shattock, Michael J.
Publicado 2020

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity

por Donzelli, Sonia, Goetz, Mara, Schmidt, Kjestine, Wolters, Markus, Stathopoulou, Konstantina, Diering, Simon, Prysyazhna, Oleksandra, Polat, Volkan, Scotcher, Jenna, Dees, Christian, Subramanian, Hariharan, Butt, Elke, Kamynina, Alisa, Schobesberger, Sophie, King, S. Bruce, Nikolaev, Viacheslav O., de Wit, Cor, Leichert, Lars I., Feil, Robert, Eaton, Philip, Cuello, Friederike
Publicado 2017

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications: Bamberg, Germany. 23-25 June, 2017

por Todd Milne, G., Sandner, Peter, Lincoln, Kathleen A., Harrison, Paul C., Chen, Hongxing, Wang, Hong, Clifford, Holly, Qian, Hu Sheng, Wong, Diane, Sarko, Chris, Fryer, Ryan, Richman, Jeremy, Reinhart, Glenn A., Boustany, Carine M., Pullen, Steven S., Andresen, Henriette, Moltzau, Lise Román, Cataliotti, Alessandro, Levy, Finn Olav, Lukowski, Robert, Frankenreiter, Sandra, Friebe, Andreas, Calamaras, Timothy, Baumgartner, Robert, McLaughlin, Angela, Aronovitz, Mark, Baur, Wendy, Wang, Guang-Rong, Kapur, Navin, Karas, Richard, Blanton, Robert, Hell, Stefan, Waldman, Scott A., Lin, Jieru E., Colon-Gonzalez, Francheska, Kim, Gilbert W., Blomain, Erik S., Merlino, Dante, Snook, Adam, Erdmann, Jeanette, Wobst, Jana, Kessler, Thorsten, Schunkert, Heribert, Walter, Ulrich, Pagel, Oliver, Walter, Elena, Gambaryan, Stepan, Smolenski, Albert, Jurk, Kerstin, Zahedi, Rene, Klinger, James R., Benza, Raymond L., Corris, Paul A., Langleben, David, Naeije, Robert, Simonneau, Gérald, Meier, Christian, Colorado, Pablo, Chang, Mi Kyung, Busse, Dennis, Hoeper, Marius M., Masferrer, Jaime L., Jacobson, Sarah, Liu, Guang, Sarno, Renee, Bernier, Sylvie, Zhang, Ping, Todd Milne, G., Flores-Costa, Roger, Currie, Mark, Hall, Katherine, Möhrle, Dorit, Reimann, Katrin, Wolter, Steffen, Wolters, Markus, Mergia, Evanthia, Eichert, Nicole, Geisler, Hyun-Soon, Ruth, Peter, Friebe, Andreas, Feil, Robert, Zimmermann, Ulrike, Koesling, Doris, Knipper, Marlies, Rüttiger, Lukas, Tanaka, Yasutake, Okamoto, Atsuko, Nojiri, Takashi, Kumazoe, Motofumi, Tokudome, Takeshi, Miura, Koichi, Hino, Jun, Hosoda, Hiroshi, Miyazato, Mikiya, Kangawa, Kenji, Kapil, Vikas, Ahluwalia, Amrita, Paolocci, Nazareno, Eaton, Philip, Campbell, James C., Henning, Philipp, Franz, Eugen, Sankaran, Banumathi, Herberg, Friedrich W., Kim, Choel, Wittwer, M., Luo, Q., Kaila, V., Dames, S. A., Tobin, Andrew, Alam, Mahmood, Rudyk, Olena, Krasemann, Susanne, Hartmann, Kristin, Prysyazhna, Oleksandra, Zhang, Min, Zhao, Lan, Weiss, Astrid, Schermuly, Ralph, Eaton, Philip, Moyes, Amie J., Chu, Sandy M., Baliga, Reshma S., Hobbs, Adrian J., Michalakis, Stylianos, Mühlfriedel, Regine, Schön, Christian, Fischer, Dominik M., Wilhelm, Barbara, Zobor, Ditta, Kohl, Susanne, Peters, Tobias, Zrenner, Eberhart, Bartz-Schmidt, Karl Ulrich, Ueffing, Marius, Wissinger, Bernd, Seeliger, Mathias, Biel, Martin, Ranek, Mark J., Kokkonen, Kristen M., Lee, Dong I., Holewinski, Ronald J., Agrawal, Vineet, Virus, Cornelia, Stevens, Donté A., Sasaki, Masayuki, Zhang, Huaqun, Mannion, Mathew M., Rainer, Peter P., Page, Richard C., Schisler, Jonathan C., Van Eyk, Jennifer E., Willis, Monte S., Kass, David A., Zaccolo, Manuela, Russwurm, Michael, Giesen, Jan, Russwurm, Corina, Füchtbauer, Ernst-Martin, Koesling, Doris, Bork, Nadja I., Nikolaev, Viacheslav O., Agulló, Luis, Floor, Martin, Villà-Freixa, Jordi, Manfra, Ornella, Calamera, Gaia, Surdo, Nicoletta C., Meier, Silja, Froese, Alexander, Nikolaev, Viacheslav O., Zaccolo, Manuela, Levy, Finn Olav, Andressen, Kjetil Wessel, Aue, Annemarie, Schwiering, Fabian, Groneberg, Dieter, Friebe, Andreas, Bajraktari, Gzona, Burhenne, Jürgen, Haefeli, Walter E., Weiss, Johanna, Beck, Katharina, Voussen, Barbara, Vincent, Alexander, Parsons, Sean P., Huizinga, Jan D., Friebe, Andreas, Mónica, Fabiola Zakia, Seto, Edward, Murad, Ferid, Bian, Ka, Burgoyne, Joseph R., Prysyazhna, Oleksandra, Richards, Daniel, Eaton, Philip, Calamera, Gaia, Bjørnerem, Marianne, Ulsund, Andrea Hembre, Kim, Jeong Joo, Kim, Choel, Levy, Finn Olav, Andressen, Kjetil Wessel, Donzelli, Sonia, Goetz, Mara, Schmidt, Kjestine, Wolters, Markus, Stathopoulou, Konstantina, Prysyazhna, Oleksandra, Scotcher, Jenna, Dees, Christian, Subramanian, Hariharan, Butt, Elke, Kamynina, Alisa, Bruce King, S., Nikolaev, Viacheslav O., de Witt, Cor, Leichert, Lars I., Feil, Robert, Eaton, Philip, Cuello, Friederike, Dobrowinski, Hyazinth, Lehners, Moritz, Schmidt, Michael Paolillo Hannes, Feil, Robert, Feil, Susanne, Wen, Lai, Wolters, Markus, Thunemann, Martin, Schmidt, Kjestine, Olbrich, Marcus, Langer, Harald, Gawaz, Meinrad, Friebe, Andreas, de Wit, Cor, Feil, Robert, Franz, Eugen, Kim, Jeong Joo, Bertinetti, Daniela, Kim, Choel, Herberg, Friedrich W., Ghofrani, Hossein-Ardeschir, Grimminger, Friedrich, Grünig, Ekkehard, Huang, Yigao, Jansa, Pavel, Jing, Zhi Cheng, Kilpatrick, David, Langleben, David, Rosenkranz, Stephan, Menezes, Flavia, Fritsch, Arno, Nikkho, Sylvia, Frey, Reiner, Humbert, Marc, Groneberg, Dieter, Aue, Annemarie, Schwiering, Fabian, Friebe, Andreas, Harloff, Manuela, Reinders, Joerg, Schlossmann, Jens, Jung, Joon, Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Solinga, Robert, Sheppeck, James E., Renhowe, Paul A., Montfort, William R., Qin, Liying, Sung, Ying-Ju, Casteel, Darren, Kim, Choel, Kollau, Alexander, Neubauer, Andrea, Schrammel, Astrid, Russwurm, Michael, Koesling, Doris, Mayer, Bernd, Kumazoe, Motofumi, Takai, Mika, Takeuchi, Chieri, Kadomatsu, Mai, Hiroi, Shun, Takamatsu, Kanako, Nojiri, Takashi, Kangawa, Kenji, Tachibana, Hirofumi, Opelt, Marissa, Eroglu, Emrah, Waldeck-Weiermair, Markus, Russwurm, Michael, Koesling, Doris, Malli, Roland, Graier, Wolfgang F., Fassett, John T., Schrammel, Astrid, Mayer, Bernd, Sollie, Selene J., Moltzau, Lise Román, Hernandez-Valladares, Maria, Berven, Frode, Levy, Finn Olav, Andressen, Kjetil W., Nojiri, Takashi, Tokudome, Takeshi, Kumazoe, Motofumi, Arai, Miki, Suzuki, Yutaka, Miura, Koichi, Hino, Jun, Hosoda, Hiroshi, Miyazato, Mikiya, Okumura, Meinoshin, Kawaoka, Shinpei, Kangawa, Kenji, Peters, Stefanie, Schmidt, Hannes, Selin Kenet, B., Nies, Sarah Helena, Frank, Katharina, Wen, Lai, Rathjen, Fritz G., Feil, Robert, Petrova, Olga N., Lamarre, Isabelle, Négrerie, Michel, Robinson, Jerid W., Egbert, Jeremy R., Davydova, Julia, Jaffe, Laurinda A., Potter, Lincoln R., Robinson, Jerid W., Blixt, Nicholas, Shuhaibar, Leia C., Warren, Gordon L., Mansky, Kim C., Jaffe, Laurinda A., Potter, Lincoln R., Romoli, Simone, Bauch, Tobias, Dröbner, Karoline, Eitner, Frank, Ruppert, Mihály, Radovits, Tamás, Korkmaz-Icöz, Sevil, Li, Shiliang, Hegedűs, Péter, Loganathan, Sivakanan, Németh, Balázs Tamás, Oláh, Attila, Mátyás, Csaba, Benke, Kálmán, Merkely, Béla, Karck, Matthias, Szabó, Gábor, Scheib, Ulrike, Broser, Matthias, Mukherjee, Shatanik, Stehfest, Katja, Gee, Christine E., Körschen, Heinz G., Oertner, Thomas G., Hegemann, Peter, Schmidt, Hannes, Dickey, Deborah M., Dumoulin, Alexandre, Kühn, Ralf, Jaffe, Laurinda, Potter, Lincoln R., Rathjen, Fritz G., Schobesberger, Sophie, Wright, Peter, Poulet, Claire, Mansfield, Catherine, Friebe, Andreas, Harding, Sian E., Nikolaev, Viacheslav O., Gorelik, Julia, Kollau, Alexander, Opelt, Marissa, Wölkart, Gerald, Gorren, Antonius C. F., Russwurm, Michael, Koesling, Doris, Schrammel, Astrid, Mayer, Bernd, Schwaerzer, Gerburg K., Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Zhuang, Shunhui, Milewicz, Dianna M., Peterson, Kirk L., Pilz, Renate, Schwiering, Fabian, Aue, Annemarie, Groneberg, Dieter, Friebe, Andreas, Argyriou, Aikaterini I., Makrynitsa, Garyfalia, Alexandropoulos, Ioannis I., Stamopoulou, Andriana, Bantzi, Marina, Giannis, Athanassios, Topouzis, Stavros, Papapetropoulos, Andreas, Spyroulias, Georgios A., Stuehr, Dennis J., Ghosh, Arnab, Dai, Yue, Misra, Saurav, Tchernychev, Boris, Jung, Joon, Liu, Guang, Silos-Santiago, Inmaculada, Hannig, Gerhard, Dao, Vu Thao-Vi, Deile, Martin, Nedvetsky, Pavel I., Güldner, Andreas, Ibarra-Alvarado, César, Gödecke, Axel, Schmidt, Harald H. H. W., Vachaviolos, Angelos, Gerling, Andrea, Thunemann, Martin, Lutz, Stefan Z., Häring, Hans-Ulrich, Krüger, Marcel A., Pichler, Bernd J., Shipston, Michael J., Feil, Susanne, Feil, Robert, Vandenwijngaert, Sara, Ledsky, Clara D., Agha, Obiajulu, Hu, Dongjian, Domian, Ibrahim J., Buys, Emmanuel S., Newton-Cheh, Christopher, Bloch, Donald B., Voussen, Barbara, Beck, Katharina, Mauro, Nadine, Keppler, Jonas, Friebe, Andreas, Ferreira, Wilson A., Chweih, Hanan, Brito, Pamela L., Almeida, Camila B., Penteado, Carla F. F., Saad, Sara S. O., Costa, Fernando F., Frenette, Paul S., Brockschnieder, Damian, Stasch, Johannes-Peter, Sandner, Peter, Conran, Nicola, Zimmer, Daniel P., Tobin, Jenny, Shea, Courtney, Sarno, Renee, Long, Kimberly, Jacobson, Sarah, Tang, Kim, Germano, Peter, Wakefield, James, Banijamali, Ali, Im, G-Yoon Jamie, Sheppeck, James E., Profy, Albert T., Todd Milne, G., Currie, Mark G., Masferrer, Jaime L.
Publicado 2017