New horizons in hypoxia signaling pathways

por Pugh, Christopher W., Ratcliffe, Peter J.
Publicado 2017

Hypoxia and oxidative stress in breast cancer: Hypoxia signalling pathways

por Pugh, Christopher W, Gleadle, Jonathan, Maxwell, Patrick H
Publicado 2001

The relationship between symptoms and blood pressure during maintenance hemodialysis

por Meredith, David J, Pugh, Christopher W, Sutherland, Sheera, Tarassenko, Lionel, Birks, Jacqueline
Publicado 2015

Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors

por Vipond, Oliver, Bull, Joshua A., Macklin, Philip S., Tillmann, Ulrike, Pugh, Christopher W., Byrne, Helen M., Harrington, Heather A.
Publicado 2021

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

por Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.
Publicado 2016

Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans

por Bishop, Tammie, Lau, Kah Weng, Epstein, Andrew C. R, Kim, Stuart K, Jiang, Min, O'Rourke, Delia, Pugh, Christopher W, Gleadle, Jonathan M, Taylor, Martin S, Hodgkin, Jonathan, Ratcliffe, Peter J
Publicado 2004

Accelerometer-measured physical activity and functional behaviours among people on dialysis

por Nawab, Khizr A, Storey, Benjamin C, Staplin, Natalie, Walmsley, Rosemary, Haynes, Richard, Sutherland, Sheera, Crosbie, Sarah, Pugh, Christopher W, Harper, Charlie H S, Landray, Martin J, Doherty, Aiden, Herrington, William G
Publicado 2020

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

por Tian, Ya-Min, Yeoh, Kar Kheng, Lee, Myung Kyu, Eriksson, Tuula, Kessler, Benedikt M., Kramer, Holger B., Edelmann, Mariola J., Willam, Carsten, Pugh, Christopher W., Schofield, Christopher J., Ratcliffe, Peter J.
Publicado 2011

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

por Hodson, Emma J., Nicholls, Lynn G., Turner, Philip J., Llyr, Ronan, Fielding, James W., Douglas, Gillian, Ratnayaka, Indrika, Robbins, Peter A., Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Publicado 2015

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

por Fielding, James W., Hodson, Emma J., Cheng, Xiaotong, Ferguson, David J. P., Eckardt, Luise, Adam, Julie, Lip, Philomena, Maton‐Howarth, Matthew, Ratnayaka, Indrika, Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Publicado 2018

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

por Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2019

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

por Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2016

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

por Bishop, Tammie, Talbot, Nick P, Turner, Philip J, Nicholls, Lynn G, Pascual, Alberto, Hodson, Emma J, Douglas, Gillian, Fielding, James W, Smith, Thomas G, Demetriades, Marina, Schofield, Christopher J, Robbins, Peter A, Pugh, Christopher W, Buckler, Keith J, Ratcliffe, Peter J
Publicado 2013

Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology

por Smith, Thomas G, Brooks, Jerome T, Balanos, George M, Lappin, Terence R, Layton, D. Mark, Leedham, Dawn L, Liu, Chun, Maxwell, Patrick H, McMullin, Mary F, McNamara, Christopher J, Percy, Melanie J, Pugh, Christopher W, Ratcliffe, Peter J, Talbot, Nick P, Treacy, Marilyn, Robbins, Peter A
Publicado 2006

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

por Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M., Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D. W., Kawamura, Akane, Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2015

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

por Cheng, Xiaotong, Prange-Barczynska, Maria, Fielding, James W., Zhang, Minghao, Burrell, Alana L., Lima, Joanna D.C.C., Eckardt, Luise, Argles, Isobel L.A., Pugh, Christopher W., Buckler, Keith J., Robbins, Peter A., Hodson, Emma J., Bruick, Richard K., Collinson, Lucy M., Rastinejad, Fraydoon, Bishop, Tammie, Ratcliffe, Peter J.
Publicado 2020

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

por Formenti, Federico, Beer, Philip A., Croft, Quentin P. P., Dorrington, Keith L., Gale, Daniel P., Lappin, Terence R. J., Lucas, Guy S., Maher, Eamonn R., Maxwell, Patrick H., McMullin, Mary F., O'Connor, David F., Percy, Melanie J., Pugh, Christopher W., Ratcliffe, Peter J., Smith, Thomas G., Talbot, Nick P., Robbins, Peter A.
Publicado 2011

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

por Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
Publicado 2017

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

por Adam, Julie, Ramracheya, Reshma, Chibalina, Margarita V., Ternette, Nicola, Hamilton, Alexander, Tarasov, Andrei I., Zhang, Quan, Rebelato, Eduardo, Rorsman, Nils J.G., Martín-del-Río, Rafael, Lewis, Amy, Özkan, Gizem, Do, Hyun Woong, Spégel, Peter, Saitoh, Kaori, Kato, Keiko, Igarashi, Kaori, Kessler, Benedikt M., Pugh, Christopher W., Tamarit-Rodriguez, Jorge, Mulder, Hindrik, Clark, Anne, Frizzell, Norma, Soga, Tomoyoshi, Ashcroft, Frances M., Silver, Andrew, Pollard, Patrick J., Rorsman, Patrik
Publicado 2017

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

por Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.
Publicado 2022