Drug Resistance in Hematological Malignancies

por Auberger, Patrick, Tamburini-Bonnefoy, Jerome, Puissant, Alexandre
Publicado 2020

The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells

por Hamouda, Mohamed-Amine, Belhacene, Nathalie, Puissant, Alexandre, Colosetti, Pascal, Robert, Guillaume, Jacquel, Arnaud, Mari, Bernard, Auberger, Patrick, Luciano, Frederic
Publicado 2014

SYK Regulates mTOR Signaling in AML

por Carnevale, Julia, Ross, Linda, Puissant, Alexandre, Banerji, Versha, Stone, Richard M., DeAngelo, Daniel J., Ross, Kenneth N., Stegmaier, Kimberly
Publicado 2013

Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

por Robert, Guillaume, Ben Sahra, Issam, Puissant, Alexandre, Colosetti, Pascal, Belhacene, Nathalie, Gounon, Pierre, Hofman, Paul, Bost, Fréderic, Cassuto, Jill-Patrice, Auberger, Patrick
Publicado 2009

Dual Role of Sp3 Transcription Factor as an Inducer of Apoptosis and a Marker of Tumour Aggressiveness

por Essafi-Benkhadir, Khadija, Grosso, Sébastien, Puissant, Alexandre, Robert, Guillaume, Essafi, Makram, Deckert, Marcel, Chamorey, Emmanuel, Dassonville, Olivier, Milano, Gérard, Auberger, Patrick, Pagès, Gilles
Publicado 2009

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

por Boros, Katalin, Puissant, Alexandre, Back, Morgan, Alexe, Gabriela, Bassil, Christopher F., Sinha, Papiya, Tholouli, Eleni, Stegmaier, Kimberly, Byers, Richard J., Rodig, Scott J.
Publicado 2015

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients

por Cluzeau, Thomas, Robert, Guillaume, Mounier, Nicolas, Karsenti, Jean Michel, Dufies, Maeva, Puissant, Alexandre, Jacquel, Arnaud, Renneville, Aline, Preudhomme, Claude, Cassuto, Jill-Patrice, Raynaud, Sophie, Luciano, Frederic, Auberger, Patrick
Publicado 2012

All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to Ponatinib

por Cassuto, Ophélie, Dufies, Maeva, Jacquel, Arnaud, Robert, Guillaume, Ginet, Clémence, Dubois, Alix, Hamouda, Amine, Puissant, Alexandre, Luciano, Fredéric, Karsenti, Jean-Michel, Legros, Laurence, Cassuto, Jill Patrice, Lenain, Pascal, Auberger, Patrick
Publicado 2012

Favorable pharmacokinetic and pharmacodynamic properties of gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukemia FLT3-...

por Vignal, Nicolas, Kelly, Loïs, Lengline, Etienne, Cabannes-Hamy, Aurélie, Siavellis, Justine, Ghez, David, Sauvageon, Hélène, Braun, Thorsten, Jacqz-Aigrain, Evelyne, Kohn, Milena, Rousselot, Philippe, Puissant, Alexandre, Raffoux, Emmanuel, Mourah, Samia, Goldwirt, Lauriane
Publicado 2023

Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

por Emdal, Kristina B., Palacio-Escat, Nicolàs, Wigerup, Caroline, Eguchi, Akihiro, Nilsson, Helén, Bekker-Jensen, Dorte B., Rönnstrand, Lars, Kazi, Julhash U., Puissant, Alexandre, Itzykson, Raphaël, Saez-Rodriguez, Julio, Masson, Kristina, Blume-Jensen, Peter, Olsen, Jesper V.
Publicado 2022

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

por Weisberg, Ellen L., Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J., Yang, Jing, Manley, Paul W., Meng, Chengcheng, Buonopane, Michael, Daley, John F., Lazo, Suzan, Wright, Renee, Weinstock, David M., Christie, Amanda L., Stegmaier, Kimberly, Griffin, James D.
Publicado 2017

Retraction Note: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML

por Dubois, Alix, Furstoss, Nathan, Calleja, Anne, Zerhouni, Marwa, Cluzeau, Thomas, Savy, Coline, Marchetti, Sandrine, Hamouda, Mohamed Amine, Boulakirba, Sonia, Orange, François, Lacas-Gervais, Sandra, Karsenti, Jean-Michel, Mounier, Nicolas, Tamburini, Jérôme, Puissant, Alexandre, Luciano, Frederic, Jacquel, Arnaud, Auberger, Patrick, Robert, Guillaume
Publicado 2020

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

por Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F., Robichaud, Amanda L., Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A., Puissant, Alexandre, Vander Heiden, Matthew G., Stegmaier, Kimberly
Publicado 2021

Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

por Benbarche, Salima, Lopez, Cécile K., Salataj, Eralda, Aid, Zakia, Thirant, Cécile, Laiguillon, Marie-Charlotte, Lecourt, Séverine, Belloucif, Yannis, Vaganay, Camille, Antonini, Marion, Hu, Jiang, da Silva Babinet, Alexandra, Ndiaye-Lobry, Delphine, Pardieu, Bryann, Petit, Arnaud, Puissant, Alexandre, Chaumeil, Julie, Mercher, Thomas, Lobry, Camille
Publicado 2022

Hematopoietic differentiation at single-cell resolution in NPM1-mutated AML

por Duchmann, Matthieu, Joudinaud, Romane, Boudry, Augustin, Pasanisi, Justine, Di Feo, Giuseppe, Kim, Rathana, Bucci, Maxime, Chauvel, Clémentine, Chat, Laureen, Larcher, Lise, Pacchiardi, Kim, Mathis, Stéphanie, Raffoux, Emmanuel, Adès, Lionel, Berthon, Céline, Clappier, Emmanuelle, Roumier, Christophe, Puissant, Alexandre, Preudhomme, Claude, Duployez, Nicolas, Itzykson, Raphaël
Publicado 2022

Relative Mitochondrial Priming Predicts Survival in Older AML Patients Treated Intensively

por Dal Bello, Reinaldo, Pacchiardi, Kim, Chauvel, Clémentine, Adès, Lionel, Braun, Thorsten, Pasanisi, Justine, Fournier, Elise, Berthon, Céline, Clappier, Emmanuelle, Raffoux, Emmanuel, Lebon, Delphine, Cluzeau, Thomas, Roumier, Christophe, Plesa, Adriana, Celli-Lebras, Karine, Dombret, Hervé, Preudhomme, Claude, Mathis, Stéphanie, Puissant, Alexandre, Gardin, Claude, Itzykson, Raphael
Publicado 2022

Targeting MTHFD2 in acute myeloid leukemia

por Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline A., Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael T., Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly
Publicado 2016

A multiparametric niche-like drug screening platform in acute myeloid leukemia

por Dal Bello, Reinaldo, Pasanisi, Justine, Joudinaud, Romane, Duchmann, Matthieu, Pardieu, Bryann, Ayaka, Paolo, Di Feo, Giuseppe, Sodaro, Gaetano, Chauvel, Clémentine, Kim, Rathana, Vasseur, Loic, Chat, Laureen, Ling, Frank, Pacchiardi, Kim, Vaganay, Camille, Berrou, Jeannig, Benaksas, Chaima, Boissel, Nicolas, Braun, Thorsten, Preudhomme, Claude, Dombret, Hervé, Raffoux, Emmanuel, Fenouille, Nina, Clappier, Emmanuelle, Adès, Lionel, Puissant, Alexandre, Itzykson, Raphael
Publicado 2022

MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

por Bassil, Christopher F., Anderson, Gray R., Mayro, Benjamin, Askin, Kayleigh N., Winter, Peter S., Gruber, Samuel, Hall, Tierney M., Hoj, Jacob P., Cerda-Smith, Christian, Hutchinson, Haley M., Killarney, Shane T., Singleton, Katherine R., Qin, Li, Jubien-Girard, Kévin, Favreau, Cécile, Martin, Anthony R., Robert, Guillaume, Benhida, Rachid, Auberger, Patrick, Pendergast, Ann Marie, Lonard, David M., Puissant, Alexandre, Wood, Kris C.
Publicado 2023

BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice

por Hamouda, Mohamed-Amine, Jacquel, Arnaud, Robert, Guillaume, Puissant, Alexandre, Richez, Valentine, Cassel, Romeo, Fenouille, Nina, Roulland, Sandrine, Gilleron, Jerome, Griessinger, Emmanuel, Dubois, Alix, Bailly-Maitre, Beatrice, Goncalves, Diogo, Mallavialle, Aude, Colosetti, Pascal, Marchetti, Sandrine, Amiot, Martine, Gomez-Bougie, Patricia, Rochet, Nathalie, Deckert, Marcel, Avet-Loiseau, Herve, Hofman, Paul, Karsenti, Jean-Michel, Jeandel, Pierre-Yves, Blin-Wakkach, Claudine, Nadel, Bertrand, Cluzeau, Thomas, Anderson, Kenneth C., Fuzibet, Jean-Gabriel, Auberger, Patrick, Luciano, Frederic
Publicado 2016