Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation

por Lim, Christine M., González Díaz, Alicia, Fuxreiter, Monika, Pun, Frank W., Zhavoronkov, Alex, Vendruscolo, Michele
Publicado 2023

High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders

por Mkrtchyan, Garik V., Veviorskiy, Alexander, Izumchenko, Evgeny, Shneyderman, Anastasia, Pun, Frank W., Ozerov, Ivan V., Aliper, Alex, Zhavoronkov, Alex, Scheibye-Knudsen, Morten
Publicado 2022

Alternative-Splicing in the Exon-10 Region of GABA(A) Receptor β(2) Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders

por Zhao, Cunyou, Xu, Zhiwen, Wang, Feng, Chen, Jianhuan, Ng, Siu-Kin, Wong, Pak-Wing, Yu, Zhiliang, Pun, Frank W., Ren, Lihuan, Lo, Wing-Sze, Tsang, Shui-Ying, Xue, Hong
Publicado 2009

Biomedical generative pre-trained based transformer language model for age-related disease target discovery

por Zagirova, Diana, Pushkov, Stefan, Leung, Geoffrey Ho Duen, Liu, Bonnie Hei Man, Urban, Anatoly, Sidorenko, Denis, Kalashnikov, Aleksandr, Kozlova, Ekaterina, Naumov, Vladimir, Pun, Frank W., Ozerov, Ivan V., Aliper, Alex, Zhavoronkov, Alex
Publicado 2023

Positive Selection within the Schizophrenia-Associated GABA(A) Receptor β(2) Gene

por Lo, Wing-Sze, Xu, Zhiwen, Yu, Zhiliang, Pun, Frank W., Ng, Siu-Kin, Chen, Jianhuan, Tong, Ka-Lok, Zhao, Cunyou, Xu, Xiaojing, Tsang, Shui-Ying, Harano, Mutsuo, Stöber, Gerald, Nimgaonkar, Vishwajit L., Xue, Hong
Publicado 2007

Social Cognitive Role of Schizophrenia Candidate Gene GABRB2

por Tsang, Shui Ying, Zhong, Songfa, Mei, Lingling, Chen, Jianhuan, Ng, Siu-Kin, Pun, Frank W., Zhao, Cunyou, Jing, Bingyi, Chark, Robin, Guo, Jianhua, Tan, Yunlong, Li, Lijun, Wang, Chuanyue, Chew, Soo Hong, Xue, Hong
Publicado 2013

Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform

por Olsen, Andrea, Harpaz, Zachary, Ren, Christopher, Shneyderman, Anastasia, Veviorskiy, Alexander, Dralkina, Maria, Konnov, Simon, Shcheglova, Olga, Pun, Frank W., Leung, Geoffrey Ho Duen, Leung, Hoi Wing, Ozerov, Ivan V., Aliper, Alex, Korzinkin, Mikhail, Zhavoronkov, Alex
Publicado 2023

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery

por Urban, Anatoly, Sidorenko, Denis, Zagirova, Diana, Kozlova, Ekaterina, Kalashnikov, Aleksandr, Pushkov, Stefan, Naumov, Vladimir, Sarkisova, Viktoria, Leung, Geoffrey Ho Duen, Leung, Hoi Wing, Pun, Frank W., Ozerov, Ivan V., Aliper, Alex, Ren, Feng, Zhavoronkov, Alex
Publicado 2023

A Recombination Hotspot in a Schizophrenia-Associated Region of GABRB2

por Ng, Siu-Kin, Lo, Wing-Sze, Pun, Frank W., Zhao, Cunyou, Yu, Zhiliang, Chen, Jianhuan, Tong, Ka-Lok, Xu, Zhiwen, Tsang, Shui-Ying, Yang, Qiang, Yu, Weichuan, Nimgaonkar, Vishwajit, Stöber, Gerald, Harano, Mutsuo, Xue, Hong
Publicado 2010

Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

por Pun, Frank W., Leung, Geoffrey Ho Duen, Leung, Hoi Wing, Liu, Bonnie Hei Man, Long, Xi, Ozerov, Ivan V., Wang, Ju, Ren, Feng, Aliper, Alexander, Izumchenko, Evgeny, Moskalev, Alexey, de Magalhães, João Pedro, Zhavoronkov, Alex
Publicado 2022

AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome

por Mei, Lingling, Ding, Xiaofan, Tsang, Shui-Ying, Pun, Frank W, Ng, Siu-Kin, Yang, Jianfeng, Zhao, Cunyou, Li, Dezhi, Wan, Weiqing, Yu, Chi-Hung, Tan, Tze-Ching, Poon, Wai-Sang, Leung, Gilberto Ka-Kit, Ng, Ho-Keung, Zhang, Liwei, Xue, Hong
Publicado 2011

Glioma Association and Balancing Selection of ZFPM2

por Tsang, Shui-Ying, Mei, Lingling, Wan, Weiqing, Li, Jun, Li, Yi, Zhao, Cunyou, Ding, Xiaofan, Pun, Frank W., Hu, Xiaoxia, Wang, Jianmin, Zhang, Junyi, Luo, Rongcheng, Cheung, Siu-Tim, Leung, Gilberto K. K., Poon, Wai-Sang, Ng, Ho-Keung, Zhang, Liwei, Xue, Hong
Publicado 2015

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform

por Pun, Frank W., Liu, Bonnie Hei Man, Long, Xi, Leung, Hoi Wing, Leung, Geoffrey Ho Duen, Mewborne, Quinlan T., Gao, Junli, Shneyderman, Anastasia, Ozerov, Ivan V., Wang, Ju, Ren, Feng, Aliper, Alexander, Bischof, Evelyne, Izumchenko, Evgeny, Guan, Xiaoming, Zhang, Ke, Lu, Bai, Rothstein, Jeffrey D., Cudkowicz, Merit E., Zhavoronkov, Alex
Publicado 2022

AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor

por Ren, Feng, Ding, Xiao, Zheng, Min, Korzinkin, Mikhail, Cai, Xin, Zhu, Wei, Mantsyzov, Alexey, Aliper, Alex, Aladinskiy, Vladimir, Cao, Zhongying, Kong, Shanshan, Long, Xi, Man Liu, Bonnie Hei, Liu, Yingtao, Naumov, Vladimir, Shneyderman, Anastasia, Ozerov, Ivan V., Wang, Ju, Pun, Frank W., Polykovskiy, Daniil A., Sun, Chong, Levitt, Michael, Aspuru-Guzik, Alán, Zhavoronkov, Alex
Publicado 2023

Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response

por Kumar, Yogesh, Yang, Jianfeng, Hu, Taobo, Chen, Lei, Xu, Zhi, Xu, Lin, Hu, Xiao-Xia, Tang, Gusheng, Wang, Jian-Min, Li, Yi, Poon, Wai-Sang, Wan, Weiqing, Zhang, Liwei, Mat, Wai-Kin, Pun, Frank W., Lee, Peggy, Cheong, Timothy H. Y., Ding, Xiaofan, Ng, Siu-Kin, Tsang, Shui-Ying, Chen, Jin-Fei, Zhang, Peng, Li, Shao, Wang, Hong-Yang, Xue, Hong
Publicado 2015