First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

por Purgatorio, Rosa, Gambacorta, Nicola, de Candia, Modesto, Catto, Marco, Rullo, Mariagrazia, Pisani, Leonardo, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2021

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

por Purgatorio, Rosa, Gambacorta, Nicola, Samarelli, Francesco, Lopopolo, Gianfranco, de Candia, Modesto, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2022

A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

por Bolognino, Isabella, Giangregorio, Nicola, Pisani, Leonardo, de Candia, Modesto, Purgatorio, Rosa, Tonazzi, Annamaria, Altomare, Cosimo Damiano, Cellamare, Saverio, Catto, Marco
Publicado 2019

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

por Purgatorio, Rosa, de Candia, Modesto, De Palma, Annalisa, De Santis, Francesco, Pisani, Leonardo, Campagna, Francesco, Cellamare, Saverio, Altomare, Cosimo Damiano, Catto, Marco
Publicado 2018

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease †

por Purgatorio, Rosa, Gambacorta, Nicola, Catto, Marco, de Candia, Modesto, Pisani, Leonardo, Espargaró, Alba, Sabaté, Raimon, Cellamare, Saverio, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2020

Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors

por Kulikova, Larisa N., Raesi, Ghulam Reza, Levickaya, Daria D., Purgatorio, Rosa, Spada, Gabriella La, Catto, Marco, Altomare, Cosimo D., Voskressensky, Leonid G.
Publicado 2023

Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity

por Paolino, Marco, de Candia, Modesto, Purgatorio, Rosa, Catto, Marco, Saletti, Mario, Tondo, Anna Rita, Nicolotti, Orazio, Cappelli, Andrea, Brizzi, Antonella, Mugnaini, Claudia, Corelli, Federico, Altomare, Cosimo D.
Publicado 2023

Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection

por De Maio, Flavio, Rullo, Mariagrazia, de Candia, Modesto, Purgatorio, Rosa, Lopopolo, Gianfranco, Santarelli, Giulia, Palmieri, Valentina, Papi, Massimiliano, Elia, Gabriella, De Candia, Erica, Sanguinetti, Maurizio, Altomare, Cosimo Damiano
Publicado 2022

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

por Titov, Alexander A., Purgatorio, Rosa, Obydennik, Arina Y., Listratova, Anna V., Borisova, Tatiana N., de Candia, Modesto, Catto, Marco, Altomare, Cosimo D., Varlamov, Alexey V., Voskressensky, Leonid G.
Publicado 2022

Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity

por Kulikova, Larisa N., Purgatorio, Rosa, Beloglazkin, Andrey A., Tafeenko, Viktor A., Reza, Raesi Gh., Levickaya, Daria D., Sblano, Sabina, Boccarelli, Angelina, de Candia, Modesto, Catto, Marco, Voskressensky, Leonid G., Altomare, Cosimo D.
Publicado 2023

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

por Nevskaya, Alisa A., Anikina, Lada V., Purgatorio, Rosa, Catto, Marco, Nicolotti, Orazio, de Candia, Modesto, Pisani, Leonardo, Borisova, Tatiana N., Miftyakhova, Almira R., Varlamov, Aleksey V., Nevskaya, Elena Yu., Borisov, Roman S., Voskressensky, Leonid G., Altomare, Cosimo D.
Publicado 2021