Explosive Expansion of βγ-Crystallin Genes in the Ancestral Vertebrate

por Kappé, Guido, Purkiss, Andrew G., van Genesen, Siebe T., Slingsby, Christine, Lubsen, Nicolette H.
Publicado 2010

Erratum to: Explosive Expansion of βγ-Crystallin Genes in the Ancestral Vertebrate

por Kappé, Guido, Purkiss, Andrew G., van Genesen, Siebe T., Slingsby, Christine, Lubsen, Nicolette H.
Publicado 2010

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R(p)- and S(p)-dNTPαS Diastereomers

por Morris, Elizabeth R., Kunzelmann, Simone, Caswell, Sarah J., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.
Publicado 2021

Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

por Ivanova, Marina E., Fletcher, Georgina C., O’Reilly, Nicola, Purkiss, Andrew G., Thompson, Barry J., McDonald, Neil Q.
Publicado 2015

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

por Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.
Publicado 2020

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

por Dagil, Robert, Ball, Neil J, Ogrodowicz, Roksana W, Hobor, Fruzsina, Purkiss, Andrew G, Kelly, Geoff, Martin, Stephen R, Taylor, Ian A, Ramos, Andres
Publicado 2019

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

por Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.
Publicado 2023

Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

por Gori, Ilaria, George, Roger, Purkiss, Andrew G, Strohbuecker, Stephanie, Randall, Rebecca A, Ogrodowicz, Roksana, Carmignac, Virginie, Faivre, Laurence, Joshi, Dhira, Kjær, Svend, Hill, Caroline S
Publicado 2021

d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition

por de Chiara, Cesira, Homšak, Miha, Prosser, Gareth A., Douglas, Holly L., Garza-Garcia, Acely, Kelly, Geoff, Purkiss, Andrew G., Tate, Edward W., de Carvalho, Luiz Pedro S.
Publicado 2020

Structural Basis of Eco1-Mediated Cohesin Acetylation

por Chao, William C. H., Wade, Benjamin O., Bouchoux, Céline, Jones, Andrew W., Purkiss, Andrew G., Federico, Stefania, O’Reilly, Nicola, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.
Publicado 2017

Erratum: Structural Basis of Eco1-Mediated Cohesin Acetylation

por Chao, William C. H., Wade, Benjamin O., Bouchoux, Céline, Jones, Andrew W., Purkiss, Andrew G., Federico, Stefania, O’Reilly, Nicola, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.
Publicado 2017

Structure of the cohesin loader Scc2

por Chao, William C. H., Murayama, Yasuto, Muñoz, Sofía, Jones, Andrew W., Wade, Benjamin O., Purkiss, Andrew G., Hu, Xiao-Wen, Borg, Aaron, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.
Publicado 2017

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

por Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.
Publicado 2021

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado 2016