Replication DNA polymerases, genome instability and cancer therapies

por Strauss, Juliet D, Pursell, Zachary F
Publicado 2023

The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection

por Hall, Kalen M., Pursell, Zachary F., Morici, Lisa A.
Publicado 2022

The high fidelity and unique error signature of human DNA polymerase ε

por Korona, Dagmara A., LeCompte, Kimberly G., Pursell, Zachary F.
Publicado 2011

Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase ε

por Pursell, Zachary F., Isoz, Isabelle, Lundström, Else-Britt, Johansson, Erik, Kunkel, Thomas A.
Publicado 2007

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity

por Pursell, Zachary F., McDonald, J. Tyson, Mathews, Christopher K., Kunkel, Thomas A.
Publicado 2008

2769. Treatment of Hypermutator Pseudomonas aeruginosa Induces Multidrug Resistance but Can Be Targeted by Combination Therapy

por Hall, Kalen M, Wimley, William C, Bojanowski, Christine M, Pursell, Zachary F, Morici, Lisa
Publicado 2023

2167. Mutational Signature Analysis to Predict Drug-resistant Pseudomonas aeruginosa

por Hall, Kalen M, Williams, Leonard G, Bojanowski, Christine M, Pursell, Zachary F, Morici, Lisa
Publicado 2023

Human DNA Polymerase ϵ Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides

por Göksenin, A. Yasemin, Zahurancik, Walter, LeCompte, Kimberly G., Taggart, David J., Suo, Zucai, Pursell, Zachary F.
Publicado 2012

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

por Aksenova, Anna, Volkov, Kirill, Maceluch, Jaroslaw, Pursell, Zachary F., Rogozin, Igor B., Kunkel, Thomas A., Pavlov, Youri I., Johansson, Erik
Publicado 2010

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

por Lujan, Scott A., Williams, Jessica S., Pursell, Zachary F., Abdulovic-Cui, Amy A., Clark, Alan B., Nick McElhinny, Stephanie A., Kunkel, Thomas A.
Publicado 2012

In colonic ρ(0) (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer

por Penrose, Harrison M., Heller, Sandra, Cable, Chloe, Nakhoul, Hani, Ungerleider, Nate, Baddoo, Melody, Pursell, Zachary F., Flemington, Erik K., Crawford, Susan E., Savkovic, Suzana D.
Publicado 2017

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development

por Park, Vivian S, Sun, Meijuan J S, Frey, Wesley D, Williams, Leonard G, Hodel, Karl P, Strauss, Juliet D, Wellens, Sydney J, Jackson, James G, Pursell, Zachary F
Publicado 2022

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

por Shinbrot, Eve, Henninger, Erin E., Weinhold, Nils, Covington, Kyle R., Göksenin, A. Yasemin, Schultz, Nikolaus, Chao, Hsu, Doddapaneni, HarshaVardhan, Muzny, Donna M., Gibbs, Richard A., Sander, Chris, Pursell, Zachary F., Wheeler, David A.
Publicado 2014

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

por Hodel, Karl P, de Borja, Richard, Henninger, Erin E, Campbell, Brittany B, Ungerleider, Nathan, Light, Nicholas, Wu, Tong, LeCompte, Kimberly G, Goksenin, A Yasemin, Bunnell, Bruce A, Tabori, Uri, Shlien, Adam, Pursell, Zachary F
Publicado 2018

MODL-25. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS, MECHANISMS OF IMMUNE EVASION, AND COMBINATORIAL IMMUNOTHERAPY

por Galati, Melissa, Li, Li, Sudhaman, Sumedha, Lipman, Tatiana, Stengs, Lucie, Elshaer, Dana, Bridge, Taylor, Semenova, Dar’ya, Edwards, Melissa, Hodel, Karl, Forster, Victoria J, Nunes, Nuno M, Martin, Alberto, Bouffet, Eric, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri
Publicado 2020