Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal...

por Thomas, Elizabeth, Thankan, Retheesh S., Purushottamachar, Puranik, Weber, David J., Njar, Vincent C. O.
Publicado 2023

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer...

por Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Purushottamachar, Puranik, Ramamurthy, Vidya P., Njar, Vincent C.O.
Publicado 2015

Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice

por Kwegyir-Afful, Andrew K., Murigi, Francis N., Purushottamachar, Puranik, Ramamurthy, Vidya P., Martin, Marlena S., Njar, Vincent C.O.
Publicado 2016

Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model

por McCarty, David J., Huang, Weiliang, Kane, Maureen A., Purushottamachar, Puranik, Gediya, Lalji K., Njar, Vincent C.O.
Publicado 2017

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer c...

por Ramalingam, Senthilmurugan, Gediya, Lalji, Kwegyir-Afful, Andrew K., Ramamurthy, Vidya P., Purushottamachar, Puranik, Mbatia, Hannah, Njar, Vincent C. O.
Publicado 2014

VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synov...

por Thankan, Retheesh S., Thomas, Elizabeth, Purushottamachar, Puranik, Weber, David J., Ramamurthy, Vidya P., Huang, Weiliang, Kane, Maureen A., Njar, Vincent C. O.
Publicado 2023

Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal transition...

por Thomas, Elizabeth, Thankan, Retheesh S., Purushottamachar, Puranik, Huang, Weiliang, Kane, Maureen A., Zhang, Yuji, Ambulos, Nicholas, Weber, David J., Njar, Vincent C. O.
Publicado 2022

Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models

por Thomas, Elizabeth, Thankan, Retheesh S., Purushottamachar, Puranik, Huang, Weiliang, Kane, Maureen A., Zhang, Yuji, Ambulos, Nicholas P., Weber, David J., Njar, Vincent C. O.
Publicado 2022

The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

por Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Gediya, Lalji K., Murigi, Francis N., Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A., Lapidus, Rena G., Njar, Vincent C. O.
Publicado 2019

Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In V...

por Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Purushottamachar, Puranik, Murigi, Francis N., Vasaitis, Tadas S., Huang, Weiliang, Kane, Maureen A., Zhang, Yuji, Ambulos, Nicholas, Tiwari, Sudhir, Srivastava, Pratima, Nnane, Ivo P., Hussain, Arif, Qiu, Yun, Weber, David J., Njar, Vincent C. O.
Publicado 2019