Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

por Purwin, Timothy J., Caksa, Signe, Sacan, Ahmet, Capparelli, Claudia, Aplin, Andrew E.
Publicado 2023

MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma

por Vu, Ha Linh, Rosenbaum, Sheera, Capparelli, Claudia, Purwin, Timothy J., Davies, Michael A., Berger, Adam C., Aplin, Andrew E.
Publicado 2015

Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma

por Tiago, Manoela, Capparelli, Claudia, Erkes, Dan A., Purwin, Timothy J., Heilman, Shea A., Berger, Adam C., Davies, Michael A., Aplin, Andrew E.
Publicado 2020

SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

por Rosenbaum, Sheera R., Tiago, Manoela, Caksa, Signe, Capparelli, Claudia, Purwin, Timothy J., Kumar, Gaurav, Glasheen, McKenna, Pomante, Danielle, Kotas, Daniel, Chervoneva, Inna, Aplin, Andrew E.
Publicado 2021

Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma

por Chua, Vivian, Orloff, Marlana, Teh, Jessica LF, Sugase, Takahito, Liao, Connie, Purwin, Timothy J, Lam, Bao Q, Terai, Mizue, Ambrosini, Grazia, Carvajal, Richard D, Schwartz, Gary, Sato, Takami, Aplin, Andrew E
Publicado 2019

CADM1 is a TWIST1-regulated suppressor of invasion and survival

por Hartsough, Edward J., Weiss, Michele B., Heilman, Shea A., Purwin, Timothy J., Kugel, Curtis H., Rosenbaum, Sheera R., Erkes, Dan A., Tiago, Manoela, HooKim, Kim, Chervoneva, Inna, Aplin, Andrew E.
Publicado 2019

FOXD3 Regulates VISTA Expression in Melanoma

por Rosenbaum, Sheera R., Knecht, Meghan, Mollaee, Mehri, Zhong, Zhijiu, Erkes, Dan A., McCue, Peter A., Chervoneva, Inna, Berger, Adam C., Lo, Jennifer A., Fisher, David E., Gershenwald, Jeffrey E., Davies, Michael A., Purwin, Timothy J., Aplin, Andrew E.
Publicado 2020

ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma

por Han, Shujun, Ren, Yibo, He, Wangxiao, Liu, Huadong, Zhi, Zhe, Zhu, Xinliang, Yang, Tielin, Rong, Yu, Ma, Bohan, Purwin, Timothy J., Ouyang, Zhenlin, Li, Caixia, Wang, Xun, Wang, Xueqiang, Yang, Huizi, Zheng, Yan, Aplin, Andrew E., Liu, Jiankang, Shao, Yongping
Publicado 2018

Publisher Correction: ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma

por Han, Shujun, Ren, Yibo, He, Wangxiao, Liu, Huadong, Zhi, Zhe, Zhu, Xinliang, Yang, Tielin, Rong, Yu, Ma, Bohan, Purwin, Timothy J., Ouyang, Zhenlin, Li, Caixia, Wang, Xun, Wang, Xueqiang, Yang, Huizi, Zheng, Yan, Aplin, Andrew E., Liu, Jiankang, Shao, Yongping
Publicado 2018

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth

por Han, Anna, Mukha, Dzmitry, Chua, Vivian, Purwin, Timothy J., Tiago, Manoela, Modasia, Bhavik, Baqai, Usman, Aumiller, Jenna L., Bechtel, Nelisa, Hunter, Emily, Danielson, Meggie, Terai, Mizue, Wedegaertner, Philip B., Sato, Takami, Landreville, Solange, Davies, Michael A., Kurtenbach, Stefan, Harbour, J. William, Schug, Zachary T., Aplin, Andrew E.
Publicado 2023

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma

por Capparelli, Claudia, Purwin, Timothy J., Glasheen, McKenna, Caksa, Signe, Tiago, Manoela, Wilski, Nicole, Pomante, Danielle, Rosenbaum, Sheera, Nguyen, Mai Q., Cai, Weijia, Franco-Barraza, Janusz, Zheng, Richard, Kumar, Gaurav, Chervoneva, Inna, Shimada, Ayako, Rebecca, Vito W., Snook, Adam E., Hookim, Kim, Xu, Xiaowei, Cukierman, Edna, Herlyn, Meenhard, Aplin, Andrew E.
Publicado 2022