Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes

por Castro, Andrea, Ozturk, Kivilcim, Pyke, Rachel Marty, Xian, Su, Zanetti, Maurizio, Carter, Hannah
Publicado 2019

Strength of immune selection in tumors varies with sex and age

por Castro, Andrea, Pyke, Rachel Marty, Zhang, Xinlian, Thompson, Wesley Kurt, Day, Chi-Ping, Alexandrov, Ludmil B., Zanetti, Maurizio, Carter, Hannah
Publicado 2020

MHC-I genotype and tumor mutational burden predict response to immunotherapy

por Goodman, Aaron M., Castro, Andrea, Pyke, Rachel Marty, Okamura, Ryosuke, Kato, Shumei, Riviere, Paul, Frampton, Garrett, Sokol, Ethan, Zhang, Xinlian, Ball, Edward D., Carter, Hannah, Kurzrock, Razelle
Publicado 2020

A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

por Pyke, Rachel Marty, Mellacheruvu, Dattatreya, Dea, Steven, Abbott, Charles W., McDaniel, Lee, Bhave, Devayani P., Zhang, Simo V., Levy, Eric, Bartha, Gabor, West, John, Snyder, Michael P., Chen, Richard O., Boyle, Sean Michael
Publicado 2022

Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation

por Pyke, Rachel Marty, Mellacheruvu, Dattatreya, Dea, Steven, Abbott, Charles W., Zhang, Simo V., Phillips, Nick A., Harris, Jason, Bartha, Gabor, Desai, Sejal, McClory, Rena, West, John, Snyder, Michael P., Chen, Richard, Boyle, Sean Michael
Publicado 2021

Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

por Abbott, Charles W., Boyle, Sean M., Pyke, Rachel Marty, McDaniel, Lee D., Levy, Eric, Navarro, Fábio C.P., Mellacheruvu, Dattatreya, Zhang, Simo V., Tan, Mengyao, Santiago, Rose, Rusan, Zeid M., Milani, Pamela, Bartha, Gabor, Harris, Jason, McClory, Rena, Snyder, Michael P., Jang, Sekwon, Chen, Richard
Publicado 2021