Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

por Pyne, Nigel J., Pyne, Susan
Publicado 2011

Sphingosine kinase 2 and multiple myeloma

por Pyne, Nigel J., Pyne, Susan
Publicado 2017

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

por Pyne, Nigel J., Pyne, Susan
Publicado 2017

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

por Pyne, Nigel J., Pyne, Susan
Publicado 2018

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

por Pyne, Susan, Edwards, Joanne, Ohotski, Jan, Pyne, Nigel J.
Publicado 2012

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androg...

por McNaughton, Melissa, Pitman, Melissa, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Publicado 2016

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular...

por El Buri, Ashref, Adams, David R., Smith, Douglas, Tate, Rothwelle J., Mullin, Margaret, Pyne, Susan, Pyne, Nigel J.
Publicado 2018

Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds

por Alsanafi, Mariam, Brown, Ryan D. R., Oh, Jeongah, Adams, David R., Torta, Federico, Pyne, Nigel J., Pyne, Susan
Publicado 2021

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

por Baek, Dong Jae, MacRitchie, Neil, Anthony, Nahoum G., Mackay, Simon P., Pyne, Susan, Pyne, Nigel J., Bittman, Robert
Publicado 2013

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

por Tonelli, Francesca, Alossaimi, Manal, Natarajan, Viswanathan, Gorshkova, Irina, Berdyshev, Evgeny, Bittman, Robert, Watson, David G., Pyne, Susan, Pyne, Nigel J
Publicado 2013

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-inde...

por Tonelli, Francesca, Lim, Keng Gat, Loveridge, Carolyn, Long, Jaclyn, Pitson, Stuart M., Tigyi, Gabor, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Publicado 2010

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

por MacRitchie, Neil, Volpert, Giora, Al Washih, Mohammed, Watson, David G., Futerman, Anthony H., Kennedy, Simon, Pyne, Susan, Pyne, Nigel J.
Publicado 2016

A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes...

por Shin, Sun-Hye, Kim, Hee-Yeon, Yoon, Hee-Soo, Park, Woo-Jae, Adams, David R., Pyne, Nigel J., Pyne, Susan, Park, Joo-Won
Publicado 2020

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

por Berdyshev, Evgeny V., Gorshkova, Irina, Usatyuk, Peter, Kalari, Satish, Zhao, Yutong, Pyne, Nigel J., Pyne, Susan, Sabbadini, Roger A., Garcia, Joe G. N., Natarajan, Viswanathan
Publicado 2011

A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells

por Brown, Ryan D.R., Veerman, Ben E.P., Oh, Jeongah, Tate, Rothwelle J., Torta, Federico, Cunningham, Margaret R., Adams, David R., Pyne, Susan, Pyne, Nigel J.
Publicado 2021

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

por Greig, Fiona H., Nather, Katrin, Ballantyne, Margaret D., Kazi, Zeshan H., Alganga, Husam, Ewart, Marie-Ann, Zaborska, Karolina E., Fertig, Bracy, Pyne, Nigel J., Pyne, Susan, Kennedy, Simon
Publicado 2019

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

por Hii, Ling-Wei, Chung, Felicia Fei-Lei, Mai, Chun Wai, Yee, Zong Yang, Chan, Hong Hao, Raja, Vijay Joseph, Dephoure, Noah Elias, Pyne, Nigel J., Pyne, Susan, Leong, Chee-Onn
Publicado 2020

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel t...

por Evangelisti, Cecilia, Evangelisti, Camilla, Teti, Gabriella, Chiarini, Francesca, Falconi, Mirella, Melchionda, Fraia, Pession, Andrea, Bertaina, Alice, Locatelli, Franco, McCubrey, James A., Beak, Dong Jae, Bittman, Robert, Pyne, Susan, Pyne, Nigel J., Martelli, Alberto M.
Publicado 2014

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

por Omar, Faisa, Findlay, Jane E., Carfray, Gemma, Allcock, Robert W., Jiang, Zhong, Moore, Caitlin, Muir, Amy L., Lannoy, Morgane, Fertig, Bracy A., Mai, Deborah, Day, Jonathan P., Bolger, Graeme, Baillie, George S., Schwiebert, Erik, Klussmann, Enno, Pyne, Nigel J., Ong, Albert C. M., Bowers, Keith, Adam, Julia M., Adams, David R., Houslay, Miles D., Henderson, David J. P.
Publicado 2019

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

por Almeida, Afonso R. M., Neto, João L., Cachucho, Ana, Euzébio, Mayara, Meng, Xiangyu, Kim, Rathana, Fernandes, Marta B., Raposo, Beatriz, Oliveira, Mariana L., Ribeiro, Daniel, Fragoso, Rita, Zenatti, Priscila P., Soares, Tiago, de Matos, Mafalda R., Corrêa, Juliana Ronchi, Duque, Mafalda, Roberts, Kathryn G., Gu, Zhaohui, Qu, Chunxu, Pereira, Clara, Pyne, Susan, Pyne, Nigel J., Barreto, Vasco M., Bernard-Pierrot, Isabelle, Clappier, Emannuelle, Mullighan, Charles G., Grosso, Ana R., Yunes, J. Andrés, Barata, João T.
Publicado 2021