Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication

por Qiu, Yuran, Yin, Xiaolan, Li, Xinyi, Wang, Yuanhao, Fu, Qiang, Huang, Renhua, Lu, Shaoyong
Publicado 2021

Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors

por He, Xinheng, Huang, Ning, Qiu, Yuran, Zhang, Jian, Liu, Yaqin, Yin, Xiao-Lan, Lu, Shaoyong
Publicado 2021

Cardiovascular toxicity of tyrosine kinase inhibitors during cancer treatment: Potential involvement of TRPM7

por Liu, Qing, Li, Suyao, Qiu, Yuran, Zhang, Jiayu, Rios, Francisco J., Zou, Zhiguo, Touyz, Rhian M.
Publicado 2023

Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy

por Ni, Duan, Wei, Jiacheng, He, Xinheng, Rehman, Ashfaq Ur, Li, Xinyi, Qiu, Yuran, Pu, Jun, Lu, Shaoyong, Zhang, Jian
Publicado 2020

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

por Qiu, Yuran, Wang, Yuanhao, Chai, Zongtao, Ni, Duan, Li, Xinyi, Pu, Jun, Chen, Jie, Zhang, Jian, Lu, Shaoyong, Lv, Chuan, Ji, Mingfei
Publicado 2021

Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

por Wang, Yuanhao, Ji, Dong, Lei, Chaoyu, Chen, Yingfei, Qiu, Yuran, Li, Xinyi, Li, Mingyu, Ni, Duan, Pu, Jun, Zhang, Jian, Fu, Qiang, Liu, Yaqin, Lu, Shaoyong
Publicado 2021

Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

por Zhang, Qiufen, Chen, Yingyi, Ni, Duan, Huang, Zhimin, Wei, Jiacheng, Feng, Li, Su, Jun-Cheng, Wei, Yingqing, Ning, Shaobo, Yang, Xiuyan, Zhao, Mingzhu, Qiu, Yuran, Song, Kun, Yu, Zhengtian, Xu, Jianrong, Li, Xinyi, Lin, Houwen, Lu, Shaoyong, Zhang, Jian
Publicado 2022