Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis

por Liu, Xia, Qu, Cheng-Kui
Publicado 2011

Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft

por Guvench, Olgun, Qu, Cheng-Kui, MacKerell, Alexander D
Publicado 2007

Molecular-Targeted Therapies for Hematologic Malignancies

por Bunting, Kevin D., Qu, Cheng-Kui, Tomasson, Michael H.
Publicado 2012

Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia

por Liu, Xiaoling, Sabnis, Himalee, Bunting, Kevin D., Qu, Cheng-Kui
Publicado 2012

Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder

por Xu, Dan, Zheng, Hong, Yu, Wen-Mei, Qu, Cheng-Kui
Publicado 2013

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis

por Yan, Yuhan, Chen, Chao, Li, Zhiguo, Zhang, Jing, Park, Narin, Qu, Cheng-Kui
Publicado 2022

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

por Tarnawsky, Stefan P., Yu, Wen-Mei, Qu, Cheng-Kui, Chan, Rebecca J., Yoder, Mervin C.
Publicado 2018

Abnormal Chemokine-Induced Responses of Immature and Mature Hematopoietic Cells from Motheaten Mice Implicate the Protein Tyrosine Phosphatase Shp-1 in Chemokine Responses

por Kim, Chang H., Qu, Cheng-Kui, Hangoc, Giao, Cooper, Scott, Anzai, Naoyuki, Feng, Gen-Sheng, Broxmeyer, Hal E.
Publicado 1999

Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

por Xu, Dan, Liu, Xia, Yu, Wen-Mei, Meyerson, Howard J., Guo, Caiying, Gerson, Stanton L., Qu, Cheng-Kui
Publicado 2011

JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β

por Yan, Yuhan, Dong, Lei, Chen, Chao, Bunting, Kevin D., Li, Qianjin, Stieglitz, Elliot, Loh, Mignon L., Qu, Cheng-Kui
Publicado 2022

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

por Liu, Wei, Yu, Wen-Mei, Zhang, Jing, Chan, Rebecca J., Loh, Mignon L., Zhang, Zheng, Bunting, Kevin D., Qu, Cheng-Kui
Publicado 2016

SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development

por Gagné-Sansfaçon, Jessica, Coulombe, Geneviève, Langlois, Marie-Josée, Langlois, Ariane, Paquet, Marilene, Carrier, Julie, Feng, Gen-Sheng, Qu, Cheng-Kui, Rivard, Nathalie
Publicado 2016

The tyrosine phosphatase Shp‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration

por Gagné‐Sansfacon, Jessica, Langlois, Ariane, Langlois, Marie‐Josée, Coulombe, Geneviève, Tremblay, Sarah, Vaillancourt‐Lavigueur, Vanessa, Qu, Cheng‐Kui, Menendez, Alfredo, Rivard, Nathalie
Publicado 2018

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development

por Zheng, Hong, Yu, Wen-Mei, Shen, Jinhua, Kang, Sumin, Hambardzumyan, Dolores, Li, James Y., Shen, Yuxian, Kenney, Anna M., Chen, Jing, Qu, Cheng-Kui
Publicado 2018

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

por Ni, Fang, Yu, Wen-Mei, Li, Zhiguo, Graham, Douglas K., Jin, Lingtao, Kang, Sumin, Rossi, Michael R., Li, Shiyong, Broxmeyer, Hal E., Qu, Cheng-Kui
Publicado 2019

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering...

por Romero-Suarez, Sandra, Shen, Jinhua, Brotto, Leticia, Hall, Todd, Mo, ChengLin, Valdivia, Héctor H., Andresen, Jon, Wacker, Michael, Nosek, Thomas M., Qu, Cheng-Kui, Brotto, Marco
Publicado 2010

DPP4 Truncated GM-CSF & IL-3 Manifest Distinct Receptor Binding & Regulatory Functions Compared to their Full Length Forms

por O’Leary, Heather Ann, Capitano, Maegan, Cooper, Scott, Mantel, Charlie, Boswell, H. Scott, Kapur, Reuben, Ramdas, Baskar, Chan, Rebecca, Deng, Lisa, Qu, Cheng-Kui, Broxmeyer, Hal E.
Publicado 2017

Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

por Zheng, Hong, Li, Qianjin, Li, Shanhu, Li, Zhiguo, Brotto, Marco, Weiss, Daiana, Prosdocimo, Domenick, Xu, Chunhui, Reddy, Ashruth, Puchowicz, Michelle, Zhao, Xinyang, Weitzmann, M Neale, Jain, Mukesh K, Qu, Cheng-Kui
Publicado 2023

AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling

por Li, Dong, Armand, Lawrence C., Sun, Fangxu, Hwang, Hyun, Wolfson, David, Rampoldi, Antonio, Liu, Rui, Forghani, Parvin, Hu, Xin, Yu, Wen-Mei, Qu, Cheng-Kui, Jones, Dean P., Wu, Ronghu, Cho, Hee Cheol, Maxwell, Joshua T., Xu, Chunhui
Publicado 2023

Methylation of dual-specificity phosphatase 4 controls cell differentiation

por Su, Hairui, Jiang, Ming, Senevirathne, Chamara, Aluri, Srinivas, Zhang, Tuo, Guo, Han, Xavier-Ferrucio, Juliana, Jin, Shuiling, Tran, Ngoc-Tung, Liu, Szu-Mam, Sun, Chiao-Wang, Zhu, Yongxia, Zhao, Qing, Chen, Yuling, Cable, LouAnn, Shen, Yudao, Liu, Jing, Qu, Cheng-Kui, Han, Xiaosi, Klug, Christopher A., Bhatia, Ravi, Chen, Yabing, Nimer, Stephen D., Zheng, Y. George, Iancu-Rubin, Camelia, Jin, Jian, Deng, Haiteng, Krause, Diane S., Xiang, Jenny, Verma, Amit, Luo, Minkui, Zhao, Xinyang
Publicado 2021