Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive pred...

por Moore, Amy, Marks, Jesse A., Quach, Bryan C., Guo, Yuelong, Bierut, Laura J., Gaddis, Nathan C., Hancock, Dana B., Page, Grier P., Johnson, Eric O.
Publicado 2023

Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

por Keele, Gregory R., Quach, Bryan C., Israel, Jennifer W., Chappell, Grace A., Lewis, Lauren, Safi, Alexias, Simon, Jeremy M., Cotney, Paul, Crawford, Gregory E., Valdar, William, Rusyn, Ivan, Furey, Terrence S.
Publicado 2020

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

por Carnes, Megan Ulmer, Quach, Bryan C., Zhou, Linran, Han, Shizhong, Tao, Ran, Mandal, Meisha, Deep-Soboslay, Amy, Marks, Jesse A., Page, Grier P., Maher, Brion S., Jaffe, Andrew E., Won, Hyejung, Bierut, Laura J., Hyde, Thomas M., Kleinman, Joel E., Johnson, Eric O., Hancock, Dana B.
Publicado 2023

Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose

por Corradin, Olivia, Sallari, Richard, Hoang, An T., Kassim, Bibi S, Hutta, Gabriella Ben, Cuoto, Lizette, Quach, Bryan C., Lovrenert, Katreya, Hays, Cameron, Gryder, Berkley E., Iskhakova, Marina, Cates, Hannah, Song, Yanwei, Bartels, Cynthia F., Hancock, Dana B., Mash, Deborah C., Johnson, Eric O., Akbarian, Schahram, Scacheri, Peter C.
Publicado 2022

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

por Quach, Bryan C., Bray, Michael J., Gaddis, Nathan C., Liu, Mengzhen, Palviainen, Teemu, Minica, Camelia C., Zellers, Stephanie, Sherva, Richard, Aliev, Fazil, Nothnagel, Michael, Young, Kendra A., Marks, Jesse A., Young, Hannah, Carnes, Megan U., Guo, Yuelong, Waldrop, Alex, Sey, Nancy Y. A., Landi, Maria T., McNeil, Daniel W., Drichel, Dmitriy, Farrer, Lindsay A., Markunas, Christina A., Vink, Jacqueline M., Hottenga, Jouke-Jan, Iacono, William G., Kranzler, Henry R., Saccone, Nancy L., Neale, Michael C., Madden, Pamela, Rietschel, Marcella, Marazita, Mary L., McGue, Matthew, Won, Hyejung, Winterer, Georg, Grucza, Richard, Dick, Danielle M., Gelernter, Joel, Caporaso, Neil E., Baker, Timothy B., Boomsma, Dorret I., Kaprio, Jaakko, Hokanson, John E., Vrieze, Scott, Bierut, Laura J., Johnson, Eric O., Hancock, Dana B.
Publicado 2020

Integration of evidence across human and model organism studies: A meeting report

por Palmer, Rohan H. C., Johnson, Emma C., Won, Hyejung, Polimanti, Renato, Kapoor, Manav, Chitre, Apurva, Bogue, Molly A., Benca‐Bachman, Chelsie E., Parker, Clarissa C., Verma, Anurag, Reynolds, Timothy, Ernst, Jason, Bray, Michael, Kwon, Soo Bin, Lai, Dongbing, Quach, Bryan C., Gaddis, Nathan C., Saba, Laura, Chen, Hao, Hawrylycz, Michael, Zhang, Shan, Zhou, Yuan, Mahaffey, Spencer, Fischer, Christian, Sanchez‐Roige, Sandra, Bandrowski, Anita, Lu, Qing, Shen, Li, Philip, Vivek, Gelernter, Joel, Bierut, Laura J., Hancock, Dana B., Edenberg, Howard J., Johnson, Eric O., Nestler, Eric J., Barr, Peter B., Prins, Pjotr, Smith, Desmond J., Akbarian, Schahram, Thorgeirsson, Thorgeir, Walton, Dave, Baker, Erich, Jacobson, Daniel, Palmer, Abraham A., Miles, Michael, Chesler, Elissa J., Emerson, Jake, Agrawal, Arpana, Martone, Maryann, Williams, Robert W.
Publicado 2021

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

por Chen, Fang, Wang, Xingyan, Jang, Seon-Kyeong, Quach, Bryan C., Weissenkampen, J. Dylan, Khunsriraksakul, Chachrit, Yang, Lina, Sauteraud, Renan, Albert, Christine M., Allred, Nicholette D. D., Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Barr, R. Graham, Becker, Diane M., Bielak, Lawrence F., Bis, Joshua C., Blangero, John, Boorgula, Meher Preethi, Chasman, Daniel I., Chavan, Sameer, Chen, Yii-Der I., Chuang, Lee-Ming, Correa, Adolfo, Curran, Joanne E., David, Sean P., Fuentes, Lisa de las, Deka, Ranjan, Duggirala, Ravindranath, Faul, Jessica D., Garrett, Melanie E., Gharib, Sina A., Guo, Xiuqing, Hall, Michael E., Hawley, Nicola L., He, Jiang, Hobbs, Brian D., Hokanson, John E., Hsiung, Chao A., Hwang, Shih-Jen, Hyde, Thomas M., Irvin, Marguerite R., Jaffe, Andrew E., Johnson, Eric O., Kaplan, Robert, Kardia, Sharon L. R., Kaufman, Joel D., Kelly, Tanika N., Kleinman, Joel E., Kooperberg, Charles, Lee, I-Te, Levy, Daniel, Lutz, Sharon M., Manichaikul, Ani W., Martin, Lisa W., Marx, Olivia, McGarvey, Stephen T., Minster, Ryan L., Moll, Matthew, Moussa, Karine A., Naseri, Take, North, Kari E., Oelsner, Elizabeth C., Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Rafaels, Nicholas, Raffield, Laura M., Reupena, Muagututi’a Sefuiva, Rich, Stephen S., Rotter, Jerome I., Schwartz, David A., Shadyab, Aladdin H., Sheu, Wayne H-H., Sims, Mario, Smith, Jennifer A., Sun, Xiao, Taylor, Kent D., Telen, Marilyn J., Watson, Harold, Weeks, Daniel E., Weir, David R., Yanek, Lisa R., Young, Kendra A., Young, Kristin L., Zhao, Wei, Hancock, Dana B., Jiang, Bibo, Vrieze, Scott, Liu, Dajiang J.
Publicado 2023