Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

por Quinlan, Roy A., Clark, John I.
Publicado 2022

Editorial: The wetware credentials of intermediate filaments involves coordinating, organising and networking in cells and tissues

por Leube, Rudolf E., Quinlan, Roy A.
Publicado 2023

Multimorbidity due to novel pathogenic variants in the WFS1/RP1/NOD2 genes: autosomal dominant congenital lamellar cataract, retinitis pigmentosa and Crohn’s disease in a British f...

por Berry, Vanita, Ionides, Alexander, Georgiou, Michalis, Quinlan, Roy A, Michaelides, Michel
Publicado 2023

Multiple Sites in αB-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro

por Houck, Scott A., Landsbury, Andrew, Clark, John I., Quinlan, Roy A.
Publicado 2011

A cell polarity protein aPKCλ is required for eye lens formation and growth

por Sugiyama, Yuki, Akimoto, Kazunori, Robinson, Michael L., Ohno, Shigeo, Quinlan, Roy A.
Publicado 2009

Radiation protection of the eye lens in medical workers—basis and impact of the ICRP recommendations

por Barnard, Stephen GR, Ainsbury, Elizabeth A, Quinlan, Roy A, Bouffler, Simon D
Publicado 2016

Changes in the quaternary structure and function of MjHSP16.5 attributable to deletion of the IXI motif and introduction of the substitution, R107G, in the α-crystallin domain

por Quinlan, Roy A., Zhang, Yan, Lansbury, Andrew, Williamson, Ian, Pohl, Ehmke, Sun, Fei
Publicado 2013

Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts

por Berry, Vanita, Ionides, Alex, Pontikos, Nikolas, Moore, Anthony T., Quinlan, Roy A., Michaelides, Michel
Publicado 2021

Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

por Chen, Mei-Hsuan, Hagemann, Tracy L., Quinlan, Roy A., Messing, Albee, Perng, Ming-Der
Publicado 2013

A gradient of matrix-bound FGF-2 and perlecan is available to lens epithelial cells()

por Wu, Weiju, Tholozan, Frederique M., Goldberg, Martin W., Bowen, Leon, Wu, Junjie, Quinlan, Roy A.
Publicado 2014

Whole Exome Sequencing Reveals Novel and Recurrent Disease-Causing Variants in Lens Specific Gap Junctional Protein Encoding Genes Causing Congenital Cataract

por Berry, Vanita, Ionides, Alex, Pontikos, Nikolas, Moghul, Ismail, Moore, Anthony T., Quinlan, Roy A., Michaelides, Michel
Publicado 2020

A recurrent variant in LIM2 causes an isolated congenital sutural/lamellar cataract in a Japanese family

por Berry, Vanita, Fujinami, Kaoru, Mochizuki, Kiyofumi, Iwata, Takeshi, Pontikos, Nikolas, Quinlan, Roy A., Michaelides, Michel
Publicado 2022

αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments

por Sharma, Sarika, Conover, Gloria M., Elliott, Jayne L., Der Perng, Ming, Herrmann, Harald, Quinlan, Roy A.
Publicado 2017

A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human len...

por Wu, Jun Jie, Wu, Weiju, Tholozan, Frederique M., Saunter, Christopher D., Girkin, John M., Quinlan, Roy A.
Publicado 2015

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

por Elliott, Jayne L., Der Perng, Ming, Prescott, Alan R., Jansen, Karin A., Koenderink, Gijsje H., Quinlan, Roy A.
Publicado 2013

The genetic landscape of crystallins in congenital cataract

por Berry, Vanita, Ionides, Alex, Pontikos, Nikolas, Georgiou, Michalis, Yu, Jing, Ocaka, Louise A., Moore, Anthony T., Quinlan, Roy A., Michaelides, Michel
Publicado 2020

Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization

por Kalligeraki, Alexia A., Isted, Archie, Jarrin, Miguel, Uwineza, Alice, Pal, Robert, Saunter, Christopher D., Girkin, John M., Obara, Boguslaw, Quinlan, Roy A.
Publicado 2020

Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape

por Markiewicz, Ewa, Barnard, Stephen, Haines, Jackie, Coster, Margaret, van Geel, Orry, Wu, Weiju, Richards, Shane, Ainsbury, Elizabeth, Rothkamm, Kai, Bouffler, Simon, Quinlan, Roy A.
Publicado 2015

Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix

por Jarrin, Miguel, Kalligeraki, Alexia A., Uwineza, Alice, Cawood, Chris S., Brown, Adrian P., Ward, Edward N., Le, Khoa, Freitag-Pohl, Stefanie, Pohl, Ehmke, Kiss, Bence, Tapodi, Antal, Quinlan, Roy A.
Publicado 2023

Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests diff...

por Quinlan, Philip R., Figeuredo, Grazziela, Mongan, Nigel, Jordan, Lee B., Bray, Susan E., Sreseli, Roman, Ashfield, Alison, Mitsch, Jurgen, van den Ijssel, Paul, Thompson, Alastair M., Quinlan, Roy A.
Publicado 2022