Advances in CRISPR-Based Functional Genomics and Nucleic Acid Detection in Pigs

por Ruan, Jinxue, Zhang, Xuying, Zhao, Shuhong, Xie, Shengsong
Publicado 2022

Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting

por Song, Jun, Yang, Dongshan, Ruan, Jinxue, Zhang, Jifeng, Chen, Yuqing Eugene, Xu, Jie
Publicado 2017

Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation

por Xu, Xiaoyun, Gao, Dongbing, Wang, Ping, Chen, Jian, Ruan, Jinxue, Xu, Jie, Xia, Xiaofeng
Publicado 2018

Genetic characteristics of polycistronic system-mediated randomly-inserted multi-transgenes in miniature pigs and mice

por Kong, Siyuan, Li, Li, Zhu, Wenjuan, Xin, Leilei, Ruan, Jinxue, Zhang, Yubo, Yang, Shulin, Li, Kui
Publicado 2018

Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis

por Kong, Siyuan, Ruan, Jinxue, Zhang, Kaiyi, Hu, Bingjun, Cheng, Yuzhu, Zhang, Yubo, Yang, Shulin, Li, Kui
Publicado 2018

Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis

por KONG, SIYUAN, RUAN, JINXUE, XIN, LEILEI, FAN, JUNHUA, XIA, JIHAN, LIU, ZHIGUO, MU, YULIAN, YANG, SHULIN, LI, KUI
Publicado 2016

A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection

por Xu, Kui, Zhang, Xiuling, Liu, Zhiguo, Ruan, Jinxue, Xu, Changjiang, Che, Jingjing, Fan, Ziyao, Mu, Yulian, Li, Kui
Publicado 2022

Identification of Glyceraldehyde-3-Phosphate Dehydrogenase Gene as an Alternative Safe Harbor Locus in Pig Genome

por Han, Xiaosong, Xiong, Youcai, Zhao, Changzhi, Xie, Shengsong, Li, Changchun, Li, Xinyun, Liu, Xiangdong, Li, Kui, Zhao, Shuhong, Ruan, Jinxue
Publicado 2019

Whole-Genome Methylation Analysis Reveals Epigenetic Variation in Cloned and Donor Pigs

por Wang, Mengfen, Feng, Shuaifei, Ma, Guanjun, Miao, Yiliang, Zuo, Bo, Ruan, Jinxue, Zhao, Shuhong, Wang, Haiyan, Du, Xiaoyong, Liu, Xiangdong
Publicado 2020

Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production

por Fan, Ziyao, Liu, Zhiguo, Xu, Kui, Wu, Tianwen, Ruan, Jinxue, Zheng, Xinmin, Bao, Shideng, Mu, Yulian, Sonstegard, Tad, Li, Kui
Publicado 2021

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

por Ma, Linyuan, Ruan, Jinxue, Song, Jun, Wen, Luan, Yang, Dongshan, Zhao, Jiangyang, Xia, Xiaofeng, Chen, Y. Eugene, Zhang, Jifeng, Xu, Jie
Publicado 2020

CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells

por Wen, Luan, Zhao, Changzhi, Song, Jun, Ma, Linyuan, Ruan, Jinxue, Xia, Xiaofeng, Chen, Y. Eugene, Zhang, Jifeng, Ma, Peter X., Xu, Jie
Publicado 2020

Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology

por Han, Xiaosong, Gao, Yang, Li, Guanglei, Xiong, Youcai, Zhao, Changzhi, Ruan, Jinxue, Ma, Yunlong, Li, Xinyun, Li, Changchun, Zhao, Shuhong, Xie, Shengsong
Publicado 2020

Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing

por Xiu, Kemao, Saunders, Laura, Wen, Luan, Ruan, Jinxue, Dong, Ruonan, Song, Jun, Yang, Dongshan, Zhang, Jifeng, Xu, Jie, Chen, Y. Eugene, Ma, Peter X.
Publicado 2022

Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs

por Ruan, Jinxue, Li, Hegang, Xu, Kui, Wu, Tianwen, Wei, Jingliang, Zhou, Rong, Liu, Zhiguo, Mu, Yulian, Yang, Shulin, Ouyang, Hongsheng, Yanru Chen-Tsai, Ruby, Li, Kui
Publicado 2015

Evaluation of the effects of sequence length and microsatellite instability on single-guide RNA activity and specificity

por Zhao, Changzhi, Wang, Yunlong, Nie, Xiongwei, Han, Xiaosong, Liu, Hailong, Li, Guanglei, Yang, Gaojuan, Ruan, Jinxue, Ma, Yunlong, Li, Xinyun, Cheng, Huijun, Zhao, Shuhong, Fang, Yaping, Xie, Shengsong
Publicado 2019

Efficient Gene Editing at Major CFTR Mutation Loci

por Ruan, Jinxue, Hirai, Hiroyuki, Yang, Dongshan, Ma, Linyuan, Hou, Xia, Jiang, Hong, Wei, Hongguang, Rajagopalan, Carthic, Mou, Hongmei, Wang, Guoshun, Zhang, Jifeng, Li, Kui, Chen, Yuqing E., Sun, Fei, Xu, Jie
Publicado 2019

CRISPR-Cas9-Mediated Cytosine Base Editing Screen for the Functional Assessment of CALR Intron Variants in Japanese Encephalitis Virus Replication

por Xiong, Youcai, Xi, Xiaoning, Xiang, Yue, Li, Sheng, Liu, Hailong, Su, Yinyu, He, Ruigao, Xiong, Chong, Xu, Bingrong, Wang, Xinyi, Fu, Liangliang, Zhao, Changzhi, Han, Xiaosong, Li, Xinyun, Xie, Shengsong, Ruan, Jinxue
Publicado 2023

Identification of the CKM Gene as a Potential Muscle-Specific Safe Harbor Locus in Pig Genome

por Xiong, Youcai, Zhuang, Rongzhi, Zhao, Guangxing, Liu, Yanwen, Su, Yinyu, Wang, Wei, Xi, Xiaoning, Yang, Yanyu, Han, Xiaosong, Xie, Shengsong, Wang, Heng, Li, Xinyun, Zuo, Bo, Zhao, Shuhong, Feng, Zheng, Ruan, Jinxue
Publicado 2022

An Inexpensive CRISPR-Based Point-of-Care Test for the Identification of Meat Species and Meat Products

por Tao, Dagang, Xiao, Xiao, Lan, Xiaochen, Xu, Bingrong, Wang, Yuan, Khazalwa, Emmanuel Mulaya, Pan, Wenya, Ruan, Jinxue, Jiang, Yu, Liu, Xiangdong, Li, Changchun, Ye, Ruizhen, Li, Xinyun, Xu, Jing, Zhao, Shuhong, Xie, Shengsong
Publicado 2022