DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models

por Jiang, Yanyan, Willmore, Elaine, Wedge, Stephen R., Ryan, Anderson J.
Publicado 2021

Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus

por Wan, Peter Kok-Ting, Ryan, Anderson J., Seymour, Leonard W.
Publicado 2021

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells

por Bokobza, Sivan M., Jiang, Yanyan, Weber, Anika M., Devery, Aoife M., Ryan, Anderson J.
Publicado 2014

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

por Sieber, Boris, Lu, Fangfang, Stribbling, Stephen M., Grieve, Adam G., Ryan, Anderson J., Freeman, Matthew
Publicado 2022

Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer

por DEVERY, AOIFE M., WADEKAR, REKHA, BOKOBZA, SIVAN M., WEBER, ANIKA M., JIANG, YANYAN, RYAN, ANDERSON J.
Publicado 2015

Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture

por Jiang, Yanyan, Allen, Danny, Kersemans, Veerle, Devery, Aoife M., Bokobza, Sivan M., Smart, Sean, Ryan, Anderson J.
Publicado 2015

Cardio-Respiratory synchronized bSSFP MRI for high throughput in vivo lung tumour quantification

por Gomes, Ana L., Kinchesh, Paul, Gilchrist, Stuart, Allen, Philip D., Lourenço, Luiza Madia, Ryan, Anderson J., Smart, Sean C.
Publicado 2019

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

por Mumin, Nuramalina H., Drobnitzky, Neele, Patel, Agata, Lourenco, Luiza Madia, Cahill, Fiona F., Jiang, Yanyan, Kong, Anthony, Ryan, Anderson J.
Publicado 2019

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

por Olcina, Monica M., Foskolou, Iosifina P., Anbalagan, Selvakumar, Senra, Joana M., Pires, Isabel M., Jiang, Yanyan, Ryan, Anderson J., Hammond, Ester M.
Publicado 2013

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality

por Jiang, Yanyan, Verbiest, Tom, Devery, Aoife M., Bokobza, Sivan M., Weber, Anika M., Leszczynska, Katarzyna B., Hammond, Ester M., Ryan, Anderson J.
Publicado 2016

Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts

por Legrand, Arnaud J., Poletto, Mattia, Pankova, Daniela, Clementi, Elena, Moore, John, Castro-Giner, Francesc, Ryan, Anderson J., O’Neill, Eric, Markkanen, Enni, Dianov, Grigory L.
Publicado 2018

CHK1 inhibition exacerbates replication stress induced by IGF blockade

por Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Publicado 2021

DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study

por Mross, Klaus, Fasol, Ulrike, Frost, Annette, Benkelmann, Robin, Kuhlmann, Jan, Büchert, Martin, Unger, Clemens, Blum, Hubert, Hennig, Jürgen, Milenkova, Tsveta P, Tessier, Jean, Krebs, Annetta D, Ryan, Anderson J, Fischer, Richard
Publicado 2009

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer

por Carter, Rebecca, Cheraghchi-Bashi, Azadeh, Westhorpe, Adam, Yu, Sheng, Shanneik, Yasmin, Seraia, Elena, Ouaret, Djamila, Inoue, Yasuhiro, Koch, Catherine, Wilding, Jenny, Ebner, Daniel, Ryan, Anderson J., Buffa, Francesca M., Sharma, Ricky A.
Publicado 2019

Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model

por Jiang, Yanyan, Martin, Jennifer, Alkadhimi, Maryam, Shigemori, Kay, Kinchesh, Paul, Gilchrist, Stuart, Kersemans, Veerle, Smart, Sean, Thompson, James M., Hill, Mark A., O’Connor, Mark J., Davies, Barry R., Ryan, Anderson J.
Publicado 2021

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

por Pirovano, Giacomo, Ashton, Thomas M, Herbert, Katharine J, Bryant, Richard J, Verrill, Clare L, Cerundolo, Lucia, Buffa, Francesca M, Prevo, Remko, Harrap, Iona, Ryan, Anderson J, Macaulay, Valentine, McKenna, William G, Higgins, Geoff S
Publicado 2017

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

por Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.
Publicado 2015

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

por Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, David R., Reeves, Helen L., Ryan, Anderson J., Wedge, Stephen R.
Publicado 2019

CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

por Walls, Gerard M., Oughton, Jamie B., Chalmers, Anthony J., Brown, Sarah, Collinson, Fiona, Forster, Martin D., Franks, Kevin N., Gilbert, Alexandra, Hanna, Gerard G., Hannaway, Nicola, Harrow, Stephen, Haswell, Tom, Hiley, Crispin T., Hinsley, Samantha, Krebs, Matthew, Murden, Geraldine, Phillip, Rachel, Ryan, Anderson J., Salem, Ahmed, Sebag-Montefoire, David, Shaw, Paul, Twelves, Chris J., Walker, Katrina, Young, Robin J., Faivre-Finn, Corinne, Greystoke, Alastair
Publicado 2020