(ADP-ribosyl)hydrolases: structure, function, and biology

por Rack, Johannes Gregor Matthias, Palazzo, Luca, Ahel, Ivan
Publicado 2020

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response

por Schützenhofer, Kira, Rack, Johannes Gregor Matthias, Ahel, Ivan
Publicado 2021

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

por Gibbs-Seymour, Ian, Fontana, Pietro, Rack, Johannes Gregor Matthias, Ahel, Ivan
Publicado 2016

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

por Rack, Johannes Gregor Matthias, Zorzini, Valentina, Zhu, Zihan, Schuller, Marion, Ahel, Dragana, Ahel, Ivan
Publicado 2020

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition

por Rack, Johannes Gregor Matthias, Ariza, Antonio, Drown, Bryon S., Henfrey, Callum, Bartlett, Edward, Shirai, Tomohiro, Hergenrother, Paul J., Ahel, Ivan
Publicado 2018

Four of a Kind: A Complete Collection of ADP-Ribosylated Histidine Isosteres Using Cu(I)- and Ru(II)-Catalyzed Click Chemistry

por Minnee, Hugo, Chung, Hayley, Rack, Johannes Gregor Matthias, van der Marel, Gijsbert A., Overkleeft, Herman S., Codée, Jeroen D. C., Ahel, Ivan, Filippov, Dmitri V.
Publicado 2023

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

por Hloušek-Kasun, Andrea, Mikolčević, Petra, Rack, Johannes Gregor Matthias, Tromans-Coia, Callum, Schuller, Marion, Jankevicius, Gytis, Matković, Marija, Bertoša, Branimir, Ahel, Ivan, Mikoč, Andreja
Publicado 2022

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling

por Fontana, Pietro, Buch-Larsen, Sara C., Suyari, Osamu, Smith, Rebecca, Suskiewicz, Marcin J., Schützenhofer, Kira, Ariza, Antonio, Rack, Johannes Gregor Matthias, Nielsen, Michael L., Ahel, Ivan
Publicado 2023

Molecular Tools for the Study of ADP‐Ribosylation: A Unified and Versatile Method to Synthesise Native Mono‐ADP‐Ribosylated Peptides

por Voorneveld, Jim, Rack, Johannes Gregor Matthias, van Gijlswijk, Luke, Meeuwenoord, Nico J., Liu, Qiang, Overkleeft, Herman S., van der Marel, Gijsbert A., Ahel, Ivan, Filippov, Dmitri V.
Publicado 2021

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

por Beijer, Danique, Agnew, Thomas, Rack, Johannes Gregor Matthias, Prokhorova, Evgeniia, Deconinck, Tine, Ceulemans, Berten, Peric, Stojan, Milic Rasic, Vedrana, De Jonghe, Peter, Ahel, Ivan, Baets, Jonathan
Publicado 2021

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens

por Rack, Johannes Gregor Matthias, Morra, Rosa, Barkauskaite, Eva, Kraehenbuehl, Rolf, Ariza, Antonio, Qu, Yue, Ortmayer, Mary, Leidecker, Orsolya, Cameron, David R., Matic, Ivan, Peleg, Anton Y., Leys, David, Traven, Ana, Ahel, Ivan
Publicado 2015

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

por Rack, Johannes Gregor Matthias, Liu, Qiang, Zorzini, Valentina, Voorneveld, Jim, Ariza, Antonio, Honarmand Ebrahimi, Kourosh, Reber, Julia M., Krassnig, Sarah C., Ahel, Dragana, van der Marel, Gijsbert A., Mangerich, Aswin, McCullagh, James S. O., Filippov, Dmitri V., Ahel, Ivan
Publicado 2021

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities

por Đukić, Nina, Strømland, Øyvind, Elsborg, Jonas Damgaard, Munnur, Deeksha, Zhu, Kang, Schuller, Marion, Chatrin, Chatrin, Kar, Pulak, Duma, Lena, Suyari, Osamu, Rack, Johannes Gregor Matthias, Baretić, Domagoj, Crudgington, Dorian Richard Kenneth, Groslambert, Joséphine, Fowler, Gerissa, Wijngaarden, Sven, Prokhorova, Evgeniia, Rehwinkel, Jan, Schüler, Herwig, Filippov, Dmitri V., Sanyal, Sumana, Ahel, Dragana, Nielsen, Michael L, Smith, Rebecca, Ahel, Ivan
Publicado 2023

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

por Schuller, Marion, Correy, Galen J., Gahbauer, Stefan, Fearon, Daren, Wu, Taiasean, Díaz, Roberto Efraín, Young, Iris D., Carvalho Martins, Luan, Smith, Dominique H., Schulze-Gahmen, Ursula, Owens, Tristan W., Deshpande, Ishan, Merz, Gregory E., Thwin, Aye C., Biel, Justin T., Peters, Jessica K., Moritz, Michelle, Herrera, Nadia, Kratochvil, Huong T., Aimon, Anthony, Bennett, James M., Brandao Neto, Jose, Cohen, Aina E., Dias, Alexandre, Douangamath, Alice, Dunnett, Louise, Fedorov, Oleg, Ferla, Matteo P., Fuchs, Martin R., Gorrie-Stone, Tyler J., Holton, James M., Johnson, Michael G., Krojer, Tobias, Meigs, George, Powell, Ailsa J., Rack, Johannes Gregor Matthias, Rangel, Victor L., Russi, Silvia, Skyner, Rachael E., Smith, Clyde A., Soares, Alexei S., Wierman, Jennifer L., Zhu, Kang, O’Brien, Peter, Jura, Natalia, Ashworth, Alan, Irwin, John J., Thompson, Michael C., Gestwicki, Jason E., von Delft, Frank, Shoichet, Brian K., Fraser, James S., Ahel, Ivan
Publicado 2021