BET Inhibitors Synergize with Carfilzomib to Induce Cell Death in Cancer Cells via Impairing Nrf1 Transcriptional Activity and Exacerbating the Unfolded Protein Response

por Vangala, Janakiram R., Potluri, Ajay, Radhakrishnan, Senthil K.
Publicado 2020

Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration

por Northrop, Amy, Byers, Holly A., Radhakrishnan, Senthil K.
Publicado 2020

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

por Radhakrishnan, Senthil K, den Besten, Willem, Deshaies, Raymond J
Publicado 2014

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity

por Northrop, Amy, Vangala, Janakiram R., Feygin, Alex, Radhakrishnan, Senthil K.
Publicado 2020

Fourth Ventricular Schwannoma: Identical Clinicopathologic Features as Schwann Cell-Derived Schwannoma with Unique Etiopathologic Origins

por Hodges, Tiffany R., Karikari, Isaac O., Nimjee, Shahid M., Tibaleka, June, Cummings, Thomas J., Radhakrishnan, Senthil, Friedman, Allan H.
Publicado 2011

Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer

por Byers, Holly A., Brooks, Amy N., Vangala, Janakiram R., Grible, Jacqueline M., Feygin, Alex, Clevenger, Charles V., Harrell, J. Chuck, Radhakrishnan, Senthil K.
Publicado 2023

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

por Tomlin, Frederick M., Gerling-Driessen, Ulla I. M., Liu, Yi-Chang, Flynn, Ryan A., Vangala, Janakiram R., Lentz, Christian S., Clauder-Muenster, Sandra, Jakob, Petra, Mueller, William F., Ordoñez-Rueda, Diana, Paulsen, Malte, Matsui, Naoko, Foley, Deirdre, Rafalko, Agnes, Suzuki, Tadashi, Bogyo, Matthew, Steinmetz, Lars M., Radhakrishnan, Senthil K., Bertozzi, Carolyn R.
Publicado 2017