The unknown impact of conditioning on HSC engraftment and clonal dynamics

por Radtke, Stefan
Publicado 2023

Safe and efficient lentiviral vector integration with HSC-targeted gene therapy

por Radtke, Stefan, Pande, Dnyanada, Enstrom, Mark, Kiem, Hans-Peter
Publicado 2023

A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for β-Hemoglobinopathies

por Humbert, Olivier, Peterson, Christopher W., Norgaard, Zachary K., Radtke, Stefan, Kiem, Hans-Peter
Publicado 2017

Isolation of a Highly Purified HSC-enriched CD34(+)CD90(+)CD45RA(−) Cell Subset for Allogeneic Transplantation in the Nonhuman Primate Large-animal Model

por Radtke, Stefan, Colonna, Lucrezia, Perez, Anai M., Hoffman, Michelle, Kean, Leslie S., Kiem, Hans-Peter
Publicado 2020

Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells

por Peterson, Christopher W., Venkataraman, Rasika, Reddy, Sowmya S., Pande, Dnyanada, Enstrom, Mark R., Radtke, Stefan, Humbert, Olivier, Kiem, Hans-Peter
Publicado 2021

Mesenchymal Stem Cells Augment the Anti-Bacterial Activity of Neutrophil Granulocytes

por Brandau, Sven, Jakob, Mark, Bruderek, Kirsten, Bootz, Friedrich, Giebel, Bernd, Radtke, Stefan, Mauel, Katharina, Jäger, Marcus, Flohé, Stefanie B., Lang, Stephan
Publicado 2014

Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates

por Murray, Jason, Einhaus, Teresa, Venkataraman, Rasika, Radtke, Stefan, Zhen, Anjie, Carrillo, Mayra A., Kitchen, Scott G., Peterson, Christopher W., Kiem, Hans-Peter
Publicado 2023

Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice

por Radtke, Stefan, Görgens, André, da Conceição Castro, Symone Vitoriano, Kordelas, Lambros, Köninger, Angela, Dürig, Jan, Möllmann, Michael, Horn, Peter A., Giebel, Bernd
Publicado 2019

Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations

por Samuelson, Clare, Radtke, Stefan, Zhu, Haiying, Llewellyn, Mallory, Fields, Emily, Cook, Savannah, Huang, Meei-Li W., Jerome, Keith R., Kiem, Hans-Peter, Humbert, Olivier
Publicado 2021

Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

por Petty, Nicholas E., Radtke, Stefan, Fields, Emily, Humbert, Olivier, Llewellyn, Mallory J., Laszlo, George S., Zhu, Haiying, Jerome, Keith R., Walter, Roland B., Kiem, Hans-Peter
Publicado 2023

Purification of Human CD34(+)CD90(+) HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy

por Radtke, Stefan, Pande, Dnyanada, Cui, Margaret, Perez, Anai M., Chan, Yan-Yi, Enstrom, Mark, Schmuck, Stefanie, Berger, Andrew, Eunson, Tom, Adair, Jennifer E., Kiem, Hans-Peter
Publicado 2020

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors

por Li, Chang, Wang, Hongjie, Gil, Sucheol, Germond, Audrey, Fountain, Connie, Baldessari, Audrey, Kim, Jiho, Liu, Zhinan, Georgakopoulou, Aphrodite, Radtke, Stefan, Raskó, Tamás, Pande, Amit, Chiang, Christina, Chin, Eli, Yannaki, Evangelia, Izsvák, Zsuzsanna, Papayannopoulou, Thalia, Kiem, Hans-Peter, Lieber, André
Publicado 2021

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants

por Peterson, Christopher W., Adair, Jennifer E., Wohlfahrt, Martin E., Deleage, Claire, Radtke, Stefan, Rust, Blake, Norman, Krystin K., Norgaard, Zachary K., Schefter, Lauren E., Sghia-Hughes, Gabriella M., Repetto, Andrea, Baldessari, Audrey, Murnane, Robert D., Estes, Jacob D., Kiem, Hans-Peter
Publicado 2019