P438: INTRACELLULAR CITRATE LEVELS MODULATE ANTI-APOPTOTIC PROTEINS TO ENHANCE VENETOCLAX SENSITIVITY IN ACUTE MYELOID LEUKEMIA STEM CELLS

por Demir, Aykut, Pouya, Alireza, Mönnig, Maximilian, Poschet, Gernot, Andresen, Carolin, Hübschmann, Daniel, Zamboni, Nicola, Müller-Tidow, Carsten, Raffel, Simon
Publicado 2023

Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells

por Poisa-Beiro, Laura, Landry, Jonathan J. M., Raffel, Simon, Tanaka, Motomu, Zaugg, Judith, Gavin, Anne-Claude, Ho, Anthony D.
Publicado 2022

P470: SINGLE-CELL METABOLIC MULTIOMICS TO IDENTIFY VULNERABILITIES IN ACUTE MYELOID LEUKEMIA STEM CELLS

por Antes, Magdalena, Besiridou, Eleni, Mönnig, Maximilian, Beneyto Calabuig, Sergi, Trumpp, Andreas, Müller-Tidow, Carsten, Haas, Simon, Velten, Lars, Raffel, Simon
Publicado 2023

S114: OUTCOME OF OLDER PATIENTS (>55 YRS) WITH NEWLY DIAGNOSED PH/BCR:ABL POSITIVE ALL PROSPECTIVELY TREATED ACCORDING TO PEDIATRIC-BASED, AGE-ADAPTED GMALL PROTOCOLS

por Lang, Fabian, Pfeifer, Heike, Raffel, Simon, Fiedler, Walter, Hanoun, Maher, Hänel, Mathias, Spriewald, Bernd, Viardot, Andreas, Vucinic, Vladan, Serve, Hubert, Hoelzer, Dieter, Gökbuget, Nicola
Publicado 2023

PB1790: LOOKING ‘BENEATH’ THE SURFACE: PROTEOMICS AND GLYCIPROTEOMICS REVEAL NOVEL TARGETS FOR CAR-T CELL THERAPIES IN ACUTE MYELOID LEUKEMIA (AML)

por Brysting, Josephine, Liu, Yi, Frenz, Joris, Schwarz, Jennifer, Sauer, Tim, Schmitt, Michael, Raffel, Simon, Renders, Simon, Zaugg, Judith B., Jayavely, Ashok, Müller-Tidow, Carsten
Publicado 2023

P323: UNCOVERING SUBCLONAL METABOLIC VULNERABILITIES IN ACUTE LYMPHOBLASTIC LEUKEMIA AT SINGLE CELL RESOLUTION

por Mönnig, Maximilian, Antes, Magdalena, Beneyto-Calabuig, Sergi, Vonficht, Dominik, Marot-Lassauzaie, Valérie, Besiriduo, Eleni, Müller-Tidow, Carsten, Haghverdi, Laleh, Haas, Simon, Velten, Lars, Raffel, Simon
Publicado 2023

The rarity of ALDH (+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients

por Hoang, Van T., Buss, Eike C., Wang, Wenwen, Hoffmann, Isabel, Raffel, Simon, Zepeda‐Moreno, Abraham, Baran, Natalia, Wuchter, Patrick, Eckstein, Volker, Trumpp, Andreas, Jauch, Anna, Ho, Anthony D., Lutz, Christoph
Publicado 2015

Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods

por Kotrová, Michaela, Koopmann, Johannes, Trautmann, Heiko, Alakel, Nael, Beck, Joachim, Nachtkamp, Kathrin, Steffen, Björn, Raffel, Simon, Viardot, Andreas, Wethmar, Klaus, Darzentas, Nikos, Baldus, Claudia D., Gökbuget, Nicola, Brüggemann, Monika
Publicado 2022

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

por Poisa-Beiro, Laura, Thoma, Judith, Landry, Jonathan, Sauer, Sven, Yamamoto, Akihisa, Eckstein, Volker, Romanov, Natalie, Raffel, Simon, Hoffmann, Georg F., Bork, Peer, Benes, Vladimir, Gavin, Anne-Claude, Tanaka, Motomu, Ho, Anthony D.
Publicado 2020

P408: COMBINATORIAL BCL-2 FAMILY EXPRESSION IN ACUTE MYELOID LEUKEMIA STEM CELLS PREDICTS CLINICAL RESPONSE TO AZACITIDINE/VENETOCLAX

por Renders, Simon, Waclawiczek, Alexander, Leppä, Aino-Maija, Stumpf, Karolin, Betz, Barbara, Reyneri, Cecilia, Donato, Elisa, Janssen, Maike, Unglaub, Julia, Shahswar, Rabia, Raffel, Simon, Hundemer, Michael, Heuser, Michael, Müller-Tidow, Carsten, Sauer, Tim, Trumpp, Andreas
Publicado 2023

The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia

por Weidenauer, Katharina, Schmidt, Christina, Rohde, Christian, Pauli, Cornelius, Blank, Maximilian F., Heid, Daniel, Waclawiczek, Alexander, Corbacioglu, Anika, Göllner, Stefanie, Lotze, Michelle, Vierbaum, Lisa, Renders, Simon, Krijgsveld, Jeroen, Raffel, Simon, Sauer, Tim, Trumpp, Andreas, Pabst, Caroline, Müller-Tidow, Carsten, Janssen, Maike
Publicado 2023

Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia

por Wang, Wenwen, Stiehl, Thomas, Raffel, Simon, Hoang, Van T., Hoffmann, Isabel, Poisa-Beiro, Laura, Saeed, Borhan R., Blume, Rachel, Manta, Linda, Eckstein, Volker, Bochtler, Tilmann, Wuchter, Patrick, Essers, Marieke, Jauch, Anna, Trumpp, Andreas, Marciniak-Czochra, Anna, Ho, Anthony D., Lutz, Christoph
Publicado 2017

Human haematopoietic stem cell lineage commitment is a continuous process

por Velten, Lars, Haas, Simon F., Raffel, Simon, Blaszkiewicz, Sandra, Islam, Saiful, Hennig, Bianca P., Hirche, Christoph, Lutz, Christoph, Buss, Eike C., Nowak, Daniel, Boch, Tobias, Hofmann, Wolf-Karsten, Ho, Anthony D., Huber, Wolfgang, Trumpp, Andreas, Essers, Marieke A.G., Steinmetz, Lars M.
Publicado 2017

General condition and comorbidity of long-term survivors of adult acute lymphoblastic leukemia

por Gökbuget, Nicola, Ihrig, Kristina, Stadler, Michael, Stelljes, Matthias, Elmaagacli, Ahmet, Starck, Michael, Raffel, Simon, Stoltefuss, Andrea, Viardot, Andreas, Kreuzer, Karl-Anton, Heidenreich, Daniela, Renzelmann, Andrea, Wäsch, Ralph, Topp, Max S., Ritter, Barbara, Reimer, Peter, Beck, Joachim, Westermann, Jörg, Wendelin, Knut, Alakel, Nael, Hanoun, Maher, Serve, Hubert, Hoelzer, Dieter
Publicado 2023

A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-i...

por Stockklausner, Clemens, Raffel, Simon, Klermund, Julia, Bandapalli, Obul Reddy, Beier, Fabian, Brümmendorf, Tim H., Bürger, Friederike, Sauer, Sven W., Hoffmann, Georg F., Lorenz, Holger, Tagliaferri, Laura, Nowak, Daniel, Hofmann, Wolf-Karsten, Buergermeister, Rebecca, Kerber, Carolin, Rausch, Tobias, Korbel, Jan O., Luke, Brian, Trumpp, Andreas, Kulozik, Andreas E.
Publicado 2015

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

por Velten, Lars, Story, Benjamin A., Hernández-Malmierca, Pablo, Raffel, Simon, Leonce, Daniel R., Milbank, Jennifer, Paulsen, Malte, Demir, Aykut, Szu-Tu, Chelsea, Frömel, Robert, Lutz, Christoph, Nowak, Daniel, Jann, Johann-Christoph, Pabst, Caroline, Boch, Tobias, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Trumpp, Andreas, Haas, Simon, Steinmetz, Lars M.
Publicado 2021

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

por Triana, Sergio, Vonficht, Dominik, Jopp-Saile, Lea, Raffel, Simon, Lutz, Raphael, Leonce, Daniel, Antes, Magdalena, Hernández-Malmierca, Pablo, Ordoñez-Rueda, Diana, Ramasz, Beáta, Boch, Tobias, Jann, Johann-Christoph, Nowak, Daniel, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Hübschmann, Daniel, Alexandrov, Theodore, Benes, Vladimir, Trumpp, Andreas, Paulsen, Malte, Velten, Lars, Haas, Simon
Publicado 2021

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

por Waclawiczek, Alexander, Leppä, Aino-Maija, Renders, Simon, Stumpf, Karolin, Reyneri, Cecilia, Betz, Barbara, Janssen, Maike, Shahswar, Rabia, Donato, Elisa, Karpova, Darja, Thiel, Vera, Unglaub, Julia M., Grabowski, Susanna, Gryzik, Stefanie, Vierbaum, Lisa, Schlenk, Richard F., Röllig, Christoph, Hundemer, Michael, Pabst, Caroline, Heuser, Michael, Raffel, Simon, Müller-Tidow, Carsten, Sauer, Tim, Trumpp, Andreas
Publicado 2023

A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia

por Zhou, Fengbiao, Aroua, Nesrine, Liu, Yi, Rohde, Christian, Cheng, Jingdong, Wirth, Anna-Katharina, Fijalkowska, Daria, Göllner, Stefanie, Lotze, Michelle, Yun, Haiyang, Yu, Xiaobing, Pabst, Caroline, Sauer, Tim, Oellerich, Thomas, Serve, Hubert, Röllig, Christoph, Bornhäuser, Martin, Thiede, Christian, Baldus, Claudia, Frye, Michaela, Raffel, Simon, Krijgsveld, Jeroen, Jeremias, Irmela, Beckmann, Roland, Trumpp, Andreas, Müller-Tidow, Carsten
Publicado 2023

Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer

por Jäger, Natalie, Schlesner, Matthias, Jones, David T.W., Raffel, Simon, Mallm, Jan-Philipp, Junge, Kristin M., Weichenhan, Dieter, Bauer, Tobias, Ishaque, Naveed, Kool, Marcel, Northcott, Paul A., Korshunov, Andrey, Drews, Ruben M., Koster, Jan, Versteeg, Rogier, Richter, Julia, Hummel, Michael, Mack, Stephen C., Taylor, Michael D., Witt, Hendrik, Swartman, Benedict, Schulte-Bockholt, Dietrich, Sultan, Marc, Yaspo, Marie-Laure, Lehrach, Hans, Hutter, Barbara, Brors, Benedikt, Wolf, Stephan, Plass, Christoph, Siebert, Reiner, Trumpp, Andreas, Rippe, Karsten, Lehmann, Irina, Lichter, Peter, Pfister, Stefan M., Eils, Roland
Publicado 2013