The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases

por Iglesias-Fernández, Javier, Raich, Lluís, Ardèvol, Albert, Rovira, Carme
Publicado 2015

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat

por Hempel, Tim, Raich, Lluís, Olsson, Simon, Azouz, Nurit P., Klingler, Andrea M., Hoffmann, Markus, Pöhlmann, Stefan, Rothenberg, Marc E., Noé, Frank
Publicado 2020

Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites

por Dadová, Jitka, Wu, Kuan-Jung, Isenegger, Patrick G., Errey, James C., Bernardes, Gonçalo J. L., Chalker, Justin M., Raich, Lluís, Rovira, Carme, Davis, Benjamin G.
Publicado 2017

Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties

por Hempel, Tim, Elez, Katarina, Krüger, Nadine, Raich, Lluís, Shrimp, Jonathan H., Danov, Olga, Jonigk, Danny, Braun, Armin, Shen, Min, Hall, Matthew D., Pöhlmann, Stefan, Hoffmann, Markus, Noé, Frank
Publicado 2021

A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism

por Jin, Yi, Petricevic, Marija, John, Alan, Raich, Lluís, Jenkins, Huw, Portela De Souza, Leticia, Cuskin, Fiona, Gilbert, Harry J., Rovira, Carme, Goddard-Borger, Ethan D., Williams, Spencer J., Davies, Gideon J.
Publicado 2016

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

por Azouz, Nurit P., Klingler, Andrea M., Callahan, Victoria, Akhrymuk, Ivan V., Elez, Katarina, Raich, Lluís, Henry, Brandon M., Benoit, Justin L., Benoit, Stefanie W., Noé, Frank, Kehn-Hall, Kylene, Rothenberg, Marc E.
Publicado 2020

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2

por Azouz, Nurit P., Klingler, Andrea M., Callahan, Victoria, Akhrymuk, Ivan V., Elez, Katarina, Raich, Lluís, Henry, Brandon M., Benoit, Justin L., Benoit, Stefanie W., Noé, Frank, Kehn-Hall, Kylene, Rothenberg, Marc E.
Publicado 2021

Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase

por Petricevic, Marija, Sobala, Lukasz F., Fernandes, Pearl Z., Raich, Lluís, Thompson, Andrew J., Bernardo-Seisdedos, Ganeko, Millet, Oscar, Zhu, Sha, Sollogoub, Matthieu, Jiménez-Barbero, Jesús, Rovira, Carme, Davies, Gideon J., Williams, Spencer J.
Publicado 2016

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

por de las Rivas, Matilde, Paul Daniel, Earnest James, Coelho, Helena, Lira-Navarrete, Erandi, Raich, Lluis, Compañón, Ismael, Diniz, Ana, Lagartera, Laura, Jiménez-Barbero, Jesús, Clausen, Henrik, Rovira, Carme, Marcelo, Filipa, Corzana, Francisco, Gerken, Thomas A., Hurtado-Guerrero, Ramon
Publicado 2018

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

por Artola, Marta, Wu, Liang, Ferraz, Maria J., Kuo, Chi-Lin, Raich, Lluís, Breen, Imogen Z., Offen, Wendy A., Codée, Jeroen D. C., van der Marel, Gijsbert A., Rovira, Carme, Aerts, Johannes M. F. G., Davies, Gideon J., Overkleeft, Herman S.
Publicado 2017

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

por Hoffmann, Markus, Hofmann-Winkler, Heike, Smith, Joan C., Krüger, Nadine, Sørensen, Lambert K., Søgaard, Ole S., Hasselstrøm, Jørgen Bo, Winkler, Michael, Hempel, Tim, Raich, Lluís, Olsson, Simon, Yamazoe, Takashi, Yamatsuta, Katsura, Mizuno, Hirotaka, Ludwig, Stephan, Noé, Frank, Sheltzer, Jason M., Kjolby, Mads, Pöhlmann, Stefan
Publicado 2020

An Epoxide Intermediate in Glycosidase Catalysis

por Sobala, Lukasz F., Speciale, Gaetano, Zhu, Sha, Raich, Lluís, Sannikova, Natalia, Thompson, Andrew J., Hakki, Zalihe, Lu, Dan, Shamsi Kazem Abadi, Saeideh, Lewis, Andrew R., Rojas-Cervellera, Víctor, Bernardo-Seisdedos, Ganeko, Zhang, Yongmin, Millet, Oscar, Jiménez-Barbero, Jesús, Bennet, Andrew J., Sollogoub, Matthieu, Rovira, Carme, Davies, Gideon J., Williams, Spencer J.
Publicado 2020

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

por Hoffmann, Markus, Hofmann-Winkler, Heike, Smith, Joan C., Krüger, Nadine, Arora, Prerna, Sørensen, Lambert K., Søgaard, Ole S., Hasselstrøm, Jørgen Bo, Winkler, Michael, Hempel, Tim, Raich, Lluís, Olsson, Simon, Danov, Olga, Jonigk, Danny, Yamazoe, Takashi, Yamatsuta, Katsura, Mizuno, Hirotaka, Ludwig, Stephan, Noé, Frank, Kjolby, Mads, Braun, Armin, Sheltzer, Jason M., Pöhlmann, Stefan
Publicado 2021

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

por Beenakker, Thomas J. M., Wander, Dennis P. A., Offen, Wendy A., Artola, Marta, Raich, Lluís, Ferraz, Maria J., Li, Kah-Yee, Houben, Judith H. P. M., van Rijssel, Erwin R., Hansen, Thomas, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.
Publicado 2017

Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes

por Schröder, Sybrin P., de Boer, Casper, McGregor, Nicholas G. S., Rowland, Rhianna J., Moroz, Olga, Blagova, Elena, Reijngoud, Jos, Arentshorst, Mark, Osborn, David, Morant, Marc D., Abbate, Eric, Stringer, Mary A., Krogh, Kristian B. R. M., Raich, Lluís, Rovira, Carme, Berrin, Jean-Guy, van Wezel, Gilles P., Ram, Arthur F. J., Florea, Bogdan I., van der Marel, Gijsbert A., Codée, Jeroen D. C., Wilson, Keith S., Wu, Liang, Davies, Gideon J., Overkleeft, Herman S.
Publicado 2019