The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

por Gerold, Kay D., Zheng, Peilin, Rainbow, Daniel B., Zernecke, Alma, Wicker, Linda S., Kissler, Stephan
Publicado 2011

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

por Asimit, Jennifer L., Rainbow, Daniel B., Fortune, Mary D., Grinberg, Nastasiya F., Wicker, Linda S., Wallace, Chris
Publicado 2019

Cellular Mechanisms of Restored β-Cell Tolerance Mediated by Protective Alleles of Idd3 and Idd5

por Hamilton-Williams, Emma E., Cheung, Jocelyn, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S., Sherman, Linda A.
Publicado 2012

Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells

por Hamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S., Sherman, Linda A.
Publicado 2010

Idd9.1 Locus Controls the Suppressive Activity of FoxP3(+)CD4(+)CD25(+) Regulatory T-Cells

por Yamanouchi, Jun, Puertas, Maria-Carmen, Verdaguer, Joan, Lyons, Paul A., Rainbow, Daniel B., Chamberlain, Giselle, Hunter, Kara M., Peterson, Laurence B., Wicker, Linda S., Santamaria, Pere
Publicado 2010

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

por Hamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A., Wicker, Linda S.
Publicado 2013

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment

por Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.
Publicado 2017

Human IL-6R(hi)TIGIT(−) CD4(+) CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile

por Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.
Publicado 2017

The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro

por Gaunt, Christopher M., Rainbow, Daniel B., Mackenzie, Ruairi J., Jarvis, Lorna B., Mousa, Hani S., Cunniffe, Nicholas, Georgieva, Zoya, Brown, J. William, Coles, Alasdair J., Jones, Joanne L.
Publicado 2021

Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

por Kochupurakkal, Nora M., Kruger, Annie J., Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B., Rossini, Aldo, Greiner, Dale L., Sayegh, Mohamed H., Wicker, Linda S., Guleria, Indira
Publicado 2014

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice

por Mattner, Jochen, Mohammed, Javid P., Fusakio, Michael E., Giessler, Claudia, Hackstein, Carl-Philipp, Opoka, Robert, Wrage, Marius, Schey, Regina, Clark, Jan, Fraser, Heather I., Rainbow, Daniel B., Wicker, Linda S.
Publicado 2019

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing

por Rainbow, Daniel B., Yang, Xin, Burren, Oliver, Pekalski, Marcin L., Smyth, Deborah J., Klarqvist, Marcus D. R., Penkett, Christopher J., Brugger, Kim, Martin, Howard, Todd, John A., Wallace, Chris, Wicker, Linda S.
Publicado 2015

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

por Trzupek, Dominik, Dunstan, Melanie, Cutler, Antony J., Lee, Mercede, Godfrey, Leila, Jarvis, Lorna, Rainbow, Daniel B., Aschenbrenner, Dominik, Jones, Joanne L., Uhlig, Holm H., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Publicado 2020

Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles

por Esposito, Laura, Hunter, Kara M. D., Clark, Jan, Rainbow, Daniel B., Stevens, Helen, Denesha, Jennifer, Duley, Simon, Dawson, Sarah, Coleman, Gillian, Nutland, Sarah, Bell, Gwynneth L., Moran, Carla, Pekalski, Marcin, Todd, John A., Wicker, Linda S.
Publicado 2014

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

por Oliveira, João J., Karrar, Sarah, Rainbow, Daniel B., Pinder, Christopher L., Clarke, Pamela, Rubio García, Arcadio, Al-Assar, Osama, Burling, Keith, Morris, Sian, Stratton, Richard, Vyse, Tim J., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Publicado 2018

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice

por Fraser, Heather I., Howlett, Sarah, Clark, Jan, Rainbow, Daniel B., Stanford, Stephanie M., Wu, Dennis J., Hsieh, Yi-Wen, Maine, Christian J., Christensen, Mikkel, Kuchroo, Vijay, Sherman, Linda A., Podolin, Patricia L., Todd, John A., Steward, Charles A., Peterson, Laurence B., Bottini, Nunzio, Wicker, Linda S.
Publicado 2015

Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics

por Burren, Oliver S, Healy, Barry C, Lam, Alex C, Schuilenburg, Helen, Dolman, Geoffrey E, Everett, Vincent H, Laneri, Davide, Nutland, Sarah, Rance, Helen E, Payne, Felicity, Smyth, Deborah, Lowe, Chris, Barratt, Bryan J, Twells, Rebecca CJ, Rainbow, Daniel B, Wicker, Linda S, Todd, John A, Walker, Neil M, Smink, Luc J
Publicado 2004

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

por Ferreira, Ricardo C., Freitag, Daniel F., Cutler, Antony J., Howson, Joanna M. M., Rainbow, Daniel B., Smyth, Deborah J., Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M., Pekalski, Marcin L., Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Butterworth, Adam S., Malarstig, Anders, Danesh, John, Todd, John A.
Publicado 2013

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

por Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Rainbow, Daniel B., Yang, Xin, Cutler, Antony J., Oliveira, Joao, Castro Dopico, Xaquin, Smyth, Deborah J., Savinykh, Natalia, Mashar, Meghavi, Vyse, Tim J., Dunger, David B., Baxendale, Helen, Chandra, Anita, Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Publicado 2017

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp(620) Risk Allele Drive the Expansion of FOXP3(+) Regulatory T Cells and PD-1 Expression

por Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.
Publicado 2019