Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

por Krečmerová, Marcela, Majer, Pavel, Rais, Rana, Slusher, Barbara S.
Publicado 2022

Clinical development of metabolic inhibitors for oncology

por Lemberg, Kathryn M., Gori, Sadakatali S., Tsukamoto, Takashi, Rais, Rana, Slusher, Barbara S.
Publicado 2022

Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

por Wozniak, Krystyna M, Vornov, James J, Mistry, Bipin M, Wu, Ying, Rais, Rana, Slusher, Barbara S
Publicado 2015

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling

por Yamashita, Alex Shimura, da Costa Rosa, Marina, Stumpo, Vittorio, Rais, Rana, Slusher, Barbara S, Riggins, Gregory J
Publicado 2020

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

por Rais, Rana, Wozniak, Krystyna, Wu, Ying, Niwa, Minae, Stathis, Marigo, Alt, Jesse, Giroux, Marc, Sawa, Akira, Rojas, Camilo, Slusher, Barbara S.
Publicado 2015

Glutamine antagonism attenuates physical and cognitive deficits in a model of MS

por Hollinger, Kristen R., Smith, Matthew D., Kirby, Leslie A., Prchalova, Eva, Alt, Jesse, Rais, Rana, Calabresi, Peter A., Slusher, Barbara S.
Publicado 2019

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

por Nizawa, Tomohiro, Bhutto, Imran A., Tiwari, Anupama, Grebe, Rhonda R., Alt, Jesse, Rais, Rana, Edwards, Malia M., Lutty, Gerard A.
Publicado 2021

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d-Amino Acid Oxidase Inhibitors

por Hin, Niyada, Duvall, Bridget, Ferraris, Dana, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Rojas, Camilo, Wu, Ying, Wozniak, Krystyna M., Slusher, Barbara S., Tsukamoto, Takashi
Publicado 2015

FSMP-18. COMPREHENSIVE METABOLIC PROFILING OF HIGH MYC MEDULLOBLASTOMA REVEALS KEY DIFFERENCES BETWEEN IN VITRO AND IN VIVO GLUCOSE AND GLUTAMINE USAGE

por Pham, Khoa, Poore, Brad, Hanaford, Allison, Maxwell, Micah J, Sweeney, Heather, Parthasarathy, Akhila, Alt, Jesse, Rais, Rana, Slusher, Barbara S, Eberhart, Charles G, Raabe, Eric H
Publicado 2021

OTME-9. Comprehensive Metabolic Profiling Of high MYC Medulloblastoma Reveals Key Differences Between In Vitro And In Vivo Glucose And Glutamine Usage

por Pham, Khoa, Poore, Brad, Hanaford, Allison, Maxwell, Micah J, Sweeney, Heather, Parthasarathy, Akhila, Alt, Jesse, Rais, Rana, Slusher, Barbara S, Eberhart, Charles G, Raabe, Eric H
Publicado 2021

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

por Gori, Sadakatali S., Thomas, Ajit G., Pal, Arindom, Wiseman, Robyn, Ferraris, Dana V., Gao, Run-duo, Wu, Ying, Alt, Jesse, Tsukamoto, Takashi, Slusher, Barbara S., Rais, Rana
Publicado 2022

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

por Parveen, Sadiya, Shen, Jessica, Lun, Shichun, Zhao, Liang, Koleske, Benjamin, Leone, Robert D., Rais, Rana, Powell, Jonathan D., Murphy, John R., Slusher, Barbara S., Bishai, William R.
Publicado 2023

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma()()

por Hanaford, Allison R., Alt, Jesse, Rais, Rana, Wang, Sabrina Z., Kaur, Harpreet, Thorek, Daniel L.J., Eberhart, Charles G., Slusher, Barbara S., Martin, Allison M., Raabe, Eric H.
Publicado 2019

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

por Pham, Khoa, Hanaford, Allison R., Poore, Brad A., Maxwell, Micah J., Sweeney, Heather, Parthasarathy, Akhila, Alt, Jesse, Rais, Rana, Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H.
Publicado 2022

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

por Parveen, Sadiya, Shen, Jessica, Lun, Shichun, Zhao, Liang, Alt, Jesse, Koleske, Benjamin, Leone, Robert D., Rais, Rana, Powell, Jonathan D., Murphy, John R., Slusher, Barbara S., Bishai, William R.
Publicado 2023

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

por Khoury, Elizabeth Smith, Sharma, Anjali, Ramireddy, Rajasekhar R, Thomas, Ajit G., Alt, Jesse, Fowler, Amanda, Rais, Rana, Tsukamoto, Takashi, Blue, Mary E., Slusher, Barbara, Kannan, Sujatha, Kannan, Rangaramanujam M.
Publicado 2020

Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice

por Kim, Boe-Hyun, Kelschenbach, Jennifer, Borjabad, Alejandra, Hadas, Eran, He, Hongxia, Potash, Mary Jane, Nedelcovych, Michael T., Rais, Rana, Haughey, Norman J., McArthur, Justin C., Slusher, Barbara S., Volsky, David J.
Publicado 2019

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

por Alt, Jesse, Gori, Sadakatali S., Lemberg, Kathryn M., Pal, Arindom, Veeravalli, Vijayabhaskar, Wu, Ying, Aguilar, Joanna M.H., Dash, Ranjeet P., Tenora, Lukáš, Majer, Pavel, Sun, Qi, Slusher, Barbara S., Rais, Rana
Publicado 2021

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

por Yoo, Seung-Wan, Waheed, Abdul A., Deme, Pragney, Tohumeken, Sehmus, Rais, Rana, Smith, Matthew D., DeMarino, Catherine, Calabresi, Peter A., Kashanchi, Fatah, Freed, Eric O., Slusher, Barbara S., Haughey, Norman J.
Publicado 2023

Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery

por Novotná, Kateřina, Tenora, Lukáš, Prchalová, Eva, Paule, James, Alt, Jesse, Veeravalli, Vijay, Lam, Jenny, Wu, Ying, Šnajdr, Ivan, Gori, Sadakatali, Mettu, Vijaya Saradhi, Tsukamoto, Takashi, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Publicado 2023