Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

por Freudenberg, Johannes M, Dunham, Ian, Sanseau, Philippe, Rajpal, Deepak K
Publicado 2018

An integrative network-based approach for drug target indication expansion

por Han, Yingnan, Wang, Clarence, Klinger, Katherine, Rajpal, Deepak K., Zhu, Cheng
Publicado 2021

Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform

por Han, Yingnan, Klinger, Katherine, Rajpal, Deepak K., Zhu, Cheng, Teeple, Erin
Publicado 2022

Significant obesity‐associated gene expression changes occur in the stomach but not intestines in obese mice

por Chen, Jing, Chen, Lihong, Sanseau, Philippe, Freudenberg, Johannes M., Rajpal, Deepak K.
Publicado 2016

Multi-omics integration reveals molecular networks and regulators of psoriasis

por Zhao, Yuqi, Jhamb, Deepali, Shu, Le, Arneson, Douglas, Rajpal, Deepak K., Yang, Xia
Publicado 2019

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository

por Lessard, Samuel, He, Chunla, Rajpal, Deepak K., Klinger, Katherine, Loh, Christine, Harris, Tim, Dumont, Jennifer
Publicado 2022

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data set...

por Freudenberg, Johannes M., Liu, Zhi, Singh, Jennifer, Thomas, Elizabeth, Traini, Christopher, Rajpal, Deepak K., Sayed, Christopher J.
Publicado 2023

Gut microbiome differences between metformin‐ and liraglutide‐treated T2DM subjects

por Wang, Zhang, Saha, Somdutta, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Rajpal, Deepak K., Brown, James R.
Publicado 2017

BET Inhibition Improves NASH and Liver Fibrosis

por Middleton, Sarah A., Rajpal, Neetu, Cutler, Leanne, Mander, Palwinder, Rioja, Inmaculada, Prinjha, Rab K., Rajpal, Deepak, Agarwal, Pankaj, Kumar, Vinod
Publicado 2018

Novel Gut-Based Pharmacology of Metformin in Patients with Type 2 Diabetes Mellitus

por Napolitano, Antonella, Miller, Sam, Nicholls, Andrew W., Baker, David, Van Horn, Stephanie, Thomas, Elizabeth, Rajpal, Deepak, Spivak, Aaron, Brown, James R., Nunez, Derek J.
Publicado 2014

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

por Bhutta, Hina Y, Rajpal, Neetu, White, Wendy, Freudenberg, Johannes M., Liu, Yaping, Way, James, Rajpal, Deepak, Cooper, David C., Young, Andrew, Tavakkoli, Ali, Chen, Lihong
Publicado 2015

The epigenetic signature of systemic insulin resistance in obese women

por Arner, Peter, Sahlqvist, Anna-Stina, Sinha, Indranil, Xu, Huan, Yao, Xiang, Waterworth, Dawn, Rajpal, Deepak, Loomis, A. Katrina, Freudenberg, Johannes M., Johnson, Toby, Thorell, Anders, Näslund, Erik, Ryden, Mikael, Dahlman, Ingrid
Publicado 2016

Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes

por Aponte, Jennifer L, Chiano, Mathias N, Yerges-Armstrong, Laura M, Hinds, David A, Tian, Chao, Gupta, Akanksha, Guo, Cong, Fraser, Dana J, Freudenberg, Johannes M, Rajpal, Deepak K, Ehm, Margaret G, Waterworth, Dawn M
Publicado 2018

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

por Rajpal, Deepak K., Klein, Jean-Louis, Mayhew, David, Boucheron, Joyce, Spivak, Aaron T., Kumar, Vinod, Ingraham, Karen, Paulik, Mark, Chen, Lihong, Van Horn, Stephanie, Thomas, Elizabeth, Sathe, Ganesh, Livi, George P., Holmes, David J., Brown, James R.
Publicado 2015

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

por Reisdorf, William C., Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E., Kumar, Vinod, Hurle, Mark R., Rajpal, Deepak K., O’Donnell, Sarah, MacDonald, Thomas T., Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J., Sanchez, Yolanda, Agarwal, Pankaj
Publicado 2019

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility

por Chiang, Shian-Huey, Harrington, W. Wallace, Luo, Guizhen, Milliken, Naphtali O., Ulrich, John C., Chen, Jing, Rajpal, Deepak K., Qian, Ying, Carpenter, Tiffany, Murray, Rusty, Geske, Robert S., Stimpson, Stephen A., Kramer, Henning F., Haffner, Curt D., Becherer, J. David, Preugschat, Frank, Billin, Andrew N.
Publicado 2015

Phenome-wide association study using research participants’ self-reported data provides insight into the Th17 and IL-17 pathway

por Ehm, Margaret G., Aponte, Jennifer L., Chiano, Mathias N., Yerges-Armstrong, Laura M., Johnson, Toby, Barker, Jonathan N., Cook, Suzanne F., Gupta, Akanksha, Hinds, David A., Li, Li, Nelson, Matthew R., Simpson, Michael A., Tian, Chao, McCarthy, Linda C., Rajpal, Deepak K., Waterworth, Dawn M.
Publicado 2017

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

por Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Publicado 2018

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury

por Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Publicado 2018

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

por Ryan, Sean K., Zelic, Matija, Han, Yingnan, Teeple, Erin, Chen, Luoman, Sadeghi, Mahdiar, Shankara, Srinivas, Guo, Lilu, Li, Cong, Pontarelli, Fabrizio, Jensen, Elizabeth H., Comer, Ashley L., Kumar, Dinesh, Zhang, Mindy, Gans, Joseph, Zhang, Bailin, Proto, Jonathan D., Saleh, Jacqueline, Dodge, James C., Savova, Virginia, Rajpal, Deepak, Ofengeim, Dimitry, Hammond, Timothy R.
Publicado 2022