Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

por Freudenberg, Johannes M, Dunham, Ian, Sanseau, Philippe, Rajpal, Deepak K
Publicado 2018

An integrative network-based approach for drug target indication expansion

por Han, Yingnan, Wang, Clarence, Klinger, Katherine, Rajpal, Deepak K., Zhu, Cheng
Publicado 2021

Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform

por Han, Yingnan, Klinger, Katherine, Rajpal, Deepak K., Zhu, Cheng, Teeple, Erin
Publicado 2022

Significant obesity‐associated gene expression changes occur in the stomach but not intestines in obese mice

por Chen, Jing, Chen, Lihong, Sanseau, Philippe, Freudenberg, Johannes M., Rajpal, Deepak K.
Publicado 2016

Multi-omics integration reveals molecular networks and regulators of psoriasis

por Zhao, Yuqi, Jhamb, Deepali, Shu, Le, Arneson, Douglas, Rajpal, Deepak K., Yang, Xia
Publicado 2019

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository

por Lessard, Samuel, He, Chunla, Rajpal, Deepak K., Klinger, Katherine, Loh, Christine, Harris, Tim, Dumont, Jennifer
Publicado 2022

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data set...

por Freudenberg, Johannes M., Liu, Zhi, Singh, Jennifer, Thomas, Elizabeth, Traini, Christopher, Rajpal, Deepak K., Sayed, Christopher J.
Publicado 2023

Gut microbiome differences between metformin‐ and liraglutide‐treated T2DM subjects

por Wang, Zhang, Saha, Somdutta, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Rajpal, Deepak K., Brown, James R.
Publicado 2017

Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes

por Aponte, Jennifer L, Chiano, Mathias N, Yerges-Armstrong, Laura M, Hinds, David A, Tian, Chao, Gupta, Akanksha, Guo, Cong, Fraser, Dana J, Freudenberg, Johannes M, Rajpal, Deepak K, Ehm, Margaret G, Waterworth, Dawn M
Publicado 2018

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

por Rajpal, Deepak K., Klein, Jean-Louis, Mayhew, David, Boucheron, Joyce, Spivak, Aaron T., Kumar, Vinod, Ingraham, Karen, Paulik, Mark, Chen, Lihong, Van Horn, Stephanie, Thomas, Elizabeth, Sathe, Ganesh, Livi, George P., Holmes, David J., Brown, James R.
Publicado 2015

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

por Reisdorf, William C., Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E., Kumar, Vinod, Hurle, Mark R., Rajpal, Deepak K., O’Donnell, Sarah, MacDonald, Thomas T., Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J., Sanchez, Yolanda, Agarwal, Pankaj
Publicado 2019

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility

por Chiang, Shian-Huey, Harrington, W. Wallace, Luo, Guizhen, Milliken, Naphtali O., Ulrich, John C., Chen, Jing, Rajpal, Deepak K., Qian, Ying, Carpenter, Tiffany, Murray, Rusty, Geske, Robert S., Stimpson, Stephen A., Kramer, Henning F., Haffner, Curt D., Becherer, J. David, Preugschat, Frank, Billin, Andrew N.
Publicado 2015

Phenome-wide association study using research participants’ self-reported data provides insight into the Th17 and IL-17 pathway

por Ehm, Margaret G., Aponte, Jennifer L., Chiano, Mathias N., Yerges-Armstrong, Laura M., Johnson, Toby, Barker, Jonathan N., Cook, Suzanne F., Gupta, Akanksha, Hinds, David A., Li, Li, Nelson, Matthew R., Simpson, Michael A., Tian, Chao, McCarthy, Linda C., Rajpal, Deepak K., Waterworth, Dawn M.
Publicado 2017

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

por Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Publicado 2018

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury

por Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Publicado 2018

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

por Qin, Pu, Arabacilar, Pelin, Bernard, Roberta E., Bao, Weike, Olzinski, Alan R., Guo, Yuanjun, Lal, Hind, Eisennagel, Stephen H., Platchek, Michael C., Xie, Wensheng, del Rosario, Julius, Nayal, Mohamad, Lu, Quinn, Roethke, Theresa, Schnackenberg, Christine G., Wright, Fe, Quaile, Michael P., Halsey, Wendy S., Hughes, Ashley M., Sathe, Ganesh M., Livi, George P., Kirkpatrick, Robert B., Qu, Xiaoyan A., Rajpal, Deepak K., Faelth Savitski, Maria, Bantscheff, Marcus, Joberty, Gerard, Bergamini, Giovanna, Force, Thomas L., Gatto, Gregory J., Hu, Erding, Willette, Robert N.
Publicado 2017

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

por Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben, Brage, Søren, Cheng, Yu-Ching, Cięszczyk, Paweł, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D., Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Ioannis, Rajpal, Deepak K., Sale, Craig, Schnurr, Theresia M., Sessa, Francesco, Shrine, Nick, Tobin, Martin D., Varley, Ian, Wain, Louise V., Wray, Naomi R., Lindgren, Cecilia M., MacArthur, Daniel G., Waterworth, Dawn M., McCarthy, Mark I., Pedersen, Oluf, Khaw, Kay-Tee, Kiel, Douglas P., Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W., North, Kathryn N., van Duijn, Cornelia M., Mather, Karen A., Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M., Richards, J. Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John R. B., Wareham, Nick J., Scott, Robert A.
Publicado 2017