An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

por Linke, Pawel, Amaning, Kwame, Maschberger, Melanie, Vallee, Francois, Steier, Valerie, Baaske, Philipp, Duhr, Stefan, Breitsprecher, Dennis, Rak, Alexey
Publicado 2015

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab

por Martin, Thomas G., Corzo, Kathryn, Chiron, Marielle, van de Velde, Helgi, Abbadessa, Giovanni, Campana, Frank, Solanki, Malini, Meng, Robin, Lee, Helen, Wiederschain, Dmitri, Zhu, Chen, Rak, Alexey, Anderson, Kenneth C.
Publicado 2019

Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity

por Ausar, Salvador F., Zhu, Shaolong, Duprez, Jessica, Cohen, Michael, Bertrand, Thomas, Steier, Valérie, Wilson, Derek J., Li, Stephen, Sheung, Anthony, Brookes, Roger H., Pedyczak, Artur, Rak, Alexey, Andrew James, D.
Publicado 2020

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction

por Kefala Stavridi, Antonia, Gontier, Amandine, Morin, Vincent, Frit, Philippe, Ropars, Virginie, Barboule, Nadia, Racca, Carine, Jonchhe, Sagun, Morten, Michael J, Andreani, Jessica, Rak, Alexey, Legrand, Pierre, Bourand-Plantefol, Alexa, Hardwick, Steven W, Chirgadze, Dimitri Y, Davey, Paul, De Oliveira, Taiana Maia, Rothenberg, Eli, Britton, Sebastien, Calsou, Patrick, Blundell, Tom L, Varela, Paloma F, Chaplin, Amanda K, Charbonnier, Jean-Baptiste
Publicado 2023

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

por Griebel, Guy, Pichat, Philippe, Beeské, Sandra, Leroy, Thibaud, Redon, Nicolas, Jacquet, Agnès, Françon, Dominique, Bert, Lionel, Even, Luc, Lopez-Grancha, Mati, Tolstykh, Tatiana, Sun, Fangxian, Yu, Qunyan, Brittain, Scott, Arlt, Heike, He, Timothy, Zhang, Bailin, Wiederschain, Dmitri, Bertrand, Thomas, Houtmann, Jacques, Rak, Alexey, Vallée, François, Michot, Nadine, Augé, Franck, Menet, Véronique, Bergis, Olivier E., George, Pascal, Avenet, Patrick, Mikol, Vincent, Didier, Michel, Escoubet, Johanna
Publicado 2015

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

por Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott G., Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse B., Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James C., Lagrange, Sophie
Publicado 2023