Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases

por Kulikowski, Ewelina, Rakai, Brooke D., Wong, Norman C. W.
Publicado 2020

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

por Rakai, Brooke D., Chrusch, Michael J., Spanswick, Simon C., Dyck, Richard H., Antle, Michael C.
Publicado 2014

Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells

por Sarsons, Christopher D., Gilham, Dean, Tsujikawa, Laura M., Wasiak, Sylwia, Fu, Li, Rakai, Brooke D., Stotz, Stephanie C., Carestia, Agostina, Sweeney, Michael, Kulikowski, Ewelina
Publicado 2023

APABETALONE (RVX-208) REDUCES ACE2 PROTEIN ABUNDANCE AND PREVENTS SARS-COV-2 SPIKE PROTEIN BINDING TO HUMAN LUNG CELLS, A MOA THAT COULD ATTENUATE VIRAL ENTRY

por Fu, Li, Gilham, Dean, Tsujikawa, Laura, Rakai, Brooke D., Wasiak, Sylwia, Stotz, Stephanie, Sarsons, Christopher D., Sweeney, Michael, Johansson, Jan, Wong, Norman, Kulikowski, Ewelina
Publicado 2021

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

por Gilham, Dean, Wasiak, Sylwia, Rakai, Brooke D., Fu, Li, Tsujikawa, Laura M., Sarsons, Christopher D., Carestia, Agostina, Lebioda, Kenneth, Johansson, Jan O., Sweeney, Michael, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina
Publicado 2023

Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy

por Fu, Li, Wasiak, Sylwia, Tsujikawa, Laura M., Rakai, Brooke D., Stotz, Stephanie C., Wong, Norman C. W., Johansson, Jan O., Sweeney, Michael, Mohan, Connie M., Khan, Aneal, Kulikowski, Ewelina
Publicado 2022

Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation

por Fu, Li, Gilham, Dean, Stotz, Stephanie C., Sarsons, Christopher D., Rakai, Brooke D., Tsujikawa, Laura M., Wasiak, Sylwia, Johansson, Jan O., Sweeney, Michael, Wong, Norman C.W., Kulikowski, Ewelina
Publicado 2023

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

por Wasiak, Sylwia, Gilham, Dean, Daze, Emily, Tsujikawa, Laura M., Halliday, Christopher, Stotz, Stephanie C., Rakai, Brooke D., Fu, Li, Jahagirdar, Ravi, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina
Publicado 2020

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

por Wasiak, Sylwia, Dzobo, Kim E., Rakai, Brooke D., Kaiser, Yannick, Versloot, Miranda, Bahjat, Mahnoush, Stotz, Stephanie C., Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Stroes, Erik S. G., Kroon, Jeffrey, Kulikowski, Ewelina
Publicado 2020

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

por Tsujikawa, Laura M., Fu, Li, Das, Shovon, Halliday, Christopher, Rakai, Brooke D., Stotz, Stephanie C., Sarsons, Christopher D., Gilham, Dean, Daze, Emily, Wasiak, Sylwia, Studer, Deborah, Rinker, Kristina D., Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina
Publicado 2019