Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept

por León-Triana, Odelaisy, Pérez-Martínez, Antonio, Ramírez-Orellana, Manuel, Pérez-García, Víctor M.
Publicado 2021

Proof-of-principle: targeted childhood leukemia prevention

por Cobaleda, César, Ramírez-Orellana, Manuel, Vicente-Dueñas, Carolina, Weiss, Andreas, Nichols, Kim E., Sánchez-García, Isidro
Publicado 2023

P336: PREDICTIVE SCORES FOR RELAPSE AND PROGRESSION DISEASE IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS BASED ON OPTICAL GENOME MAPPING TECHNOLOGY

por Garcia Martinez, Jorge, Garcia Sanchez, Elena, Gomez, Ana, Giménez, Reyes, Benito, Ana, Herrero, Blanca, Abad, Lorea, Castillo, Ana, Madero, Luis, Ramirez Orellana, Manuel
Publicado 2023

A Mathematical Description of the Bone Marrow Dynamics during CAR T-Cell Therapy in B-Cell Childhood Acute Lymphoblastic Leukemia

por Martínez-Rubio, Álvaro, Chulián, Salvador, Blázquez Goñi, Cristina, Ramírez Orellana, Manuel, Pérez Martínez, Antonio, Navarro-Zapata, Alfonso, Ferreras, Cristina, Pérez-García, Victor M., Rosa, María
Publicado 2021

Intraosseous injection of mesenchymal stem cells for the treatment of osteonecrosis of the immature femoral head and prevention of head deformity: A study in a pig model

por Martínez-Álvarez, Sergio, Galán-Olleros, María, Azorín-Cuadrillero, Daniel, Palazón-Quevedo, Ángel, González-Murillo, África, Melen-Frajlich, Gustavo J, Ramírez-Orellana, Manuel, Epeldegui-Torre, Tomás, Forriol, Francisco
Publicado 2023

TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia

por Bueno, Clara, Martínez, Alba, Romecin, Paola Alejandra, Zanetti, Samanta Romina, Tirtakusuma, Ricky, Genesca, Eulalia, Camós, Mireia, Ramírez-Orellana, Manuel, Anguita, Eduardo, Ballerini, Paola, Locatelli, Franco, Fuster, José Luis, Menéndez, Pablo
Publicado 2023

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

por Vinaixa, María, Canelles, Sandra, González-Murillo, África, Ferreira, Vítor, Grajales, Diana, Guerra-Cantera, Santiago, Campillo-Calatayud, Ana, Ramírez-Orellana, Manuel, Yanes, Óscar, Frago, Laura M., Valverde, Ángela M., Barrios, Vicente
Publicado 2021

The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells

por Villanueva, Andrea A., Puvogel, Sofía, Lois, Pablo, Muñoz-Palma, Ernesto, Ramírez Orellana, Manuel, Lubieniecki, Fabiana, Casco Claro, Fernando, Gallegos, Iván, García-Castro, Javier, Sanchez-Gomez, Pilar, Torres, Vicente A., Palma, Verónica
Publicado 2018

High-Dimensional Analysis of Single-Cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukaemia

por Chulián, Salvador, Martínez-Rubio, Álvaro, Pérez-García, Víctor M., Rosa, María, Blázquez Goñi, Cristina, Rodríguez Gutiérrez, Juan Francisco, Hermosín-Ramos, Lourdes, Molinos Quintana, Águeda, Caballero-Velázquez, Teresa, Ramírez-Orellana, Manuel, Castillo Robleda, Ana, Fernández-Martínez, Juan Luis
Publicado 2020

The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

por Villanueva, Andrea A., Sanchez-Gomez, Pilar, Muñoz-Palma, Ernesto, Puvogel, Sofía, Casas, Bárbara S., Arriagada, Cecilia, Peña-Villalobos, Isaac, Lois, Pablo, Ramírez Orellana, Manuel, Lubieniecki, Fabiana, Casco Claro, Fernando, Gallegos, Iván, García-Castro, Javier, Torres, Vicente A., Palma, Verónica
Publicado 2021

TYK2 Variants in B-Acute Lymphoblastic Leukaemia

por Turrubiartes-Martínez, Edgar, Bodega-Mayor, Irene, Delgado-Wicke, Pablo, Molina-Jiménez, Francisca, Casique-Aguirre, Diana, González-Andrade, Martín, Rapado, Inmaculada, Camós, Mireia, Díaz-de-Heredia, Cristina, Barragán, Eva, Ramírez-Orellana, Manuel, Aguado, Beatriz, Figuera, Ángela, Martínez-López, Joaquín, Fernández-Ruiz, Elena
Publicado 2020

The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia

por Chulián, Salvador, Stolz, Bernadette J., Martínez-Rubio, Álvaro, Blázquez Goñi, Cristina, Rodríguez Gutiérrez, Juan F., Caballero Velázquez, Teresa, Molinos Quintana, Águeda, Ramírez Orellana, Manuel, Castillo Robleda, Ana, Fuster Soler, José Luis, Minguela Puras, Alfredo, Martínez Sánchez, María V., Rosa, María, Pérez-García, Víctor M., Byrne, Helen M.
Publicado 2023

The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia

por Lopez-Millan, Belen, Costales, Paula, Gutiérrez-Agüera, Francisco, Díaz de la Guardia, Rafael, Roca-Ho, Heleia, Vinyoles, Meritxell, Rubio-Gayarre, Alba, Safi, Rémi, Castaño, Julio, Romecín, Paola Alejandra, Ramírez-Orellana, Manuel, Anguita, Eduardo, Jeremias, Irmela, Zamora, Lurdes, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Morís, Francisco, Menendez, Pablo
Publicado 2022

Engraftment characterization of risk-stratified AML in NSGS mice

por Díaz de la Guardia, Rafael, Velasco-Hernandez, Talía, Gutiérrez-Agüera, Francisco, Roca-Ho, Heleia, Molina, Oscar, Nombela-Arrieta, Cesar, Bataller, Alex, Fuster, Jose Luis, Anguita, Eduardo, Vives, Susana, Zamora, Lurdes, Nomdedeu, Josep, Gómez-Casares, María Teresa, Ramírez-Orellana, Manuel, Lapillonne, Helene, Ramos-Mejia, Verónica, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Lopez-Millan, Belen, Menéndez, Pablo
Publicado 2021

Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

por Isidro-Hernández, Marta, Mayado, Andrea, Casado-García, Ana, Martínez-Cano, Jorge, Palmi, Chiara, Fazio, Grazia, Orfao, Alberto, Ribera, Jordi, Ribera, Josep Maria, Zamora, Lurdes, Raboso-Gallego, Javier, Blanco, Oscar, Alonso-López, Diego, De Las Rivas, Javier, Jiménez, Rafael, García Criado, Francisco Javier, García Cenador, María Begoña, Ramírez-Orellana, Manuel, Cazzaniga, Giovanni, Cobaleda, César, Vicente-Dueñas, Carolina, Sánchez-García, Isidro
Publicado 2020

Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia

por Ramos‐Muntada, Mireia, Trincado, Juan L., Blanco, Joan, Bueno, Clara, Rodríguez‐Cortez, Virginia C., Bataller, Alex, López‐Millán, Belén, Schwab, Claire, Ortega, Margarita, Velasco, Pablo, Blanco, Maria L., Nomdedeu, Josep, Ramírez‐Orellana, Manuel, Minguela, Alfredo, Fuster, Jose L., Cuatrecasas, Esther, Camós, Mireia, Ballerini, Paola, Escherich, Gabriele, Boer, Judith, DenBoer, Monique, Hernández‐Rivas, Jesús M., Calasanz, Maria J., Cazzaniga, Giovanni, Harrison, Christine J., Menéndez, Pablo, Molina, Oscar
Publicado 2022

Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice

por Isidro-Hernández, Marta, Casado-García, Ana, Oak, Ninad, Alemán-Arteaga, Silvia, Ruiz-Corzo, Belén, Martínez-Cano, Jorge, Mayado, Andrea, Sánchez, Elena G., Blanco, Oscar, Gaspar, Ma Luisa, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, Criado, Francisco Javier García, Cenador, María Begoña García, Ramírez-Orellana, Manuel, de Andrés, Belén, Vicente-Dueñas, Carolina, Cobaleda, César, Nichols, Kim E., Sánchez-García, Isidro
Publicado 2023

Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

por Casado-García, Ana, Isidro-Hernández, Marta, Oak, Ninad, Mayado, Andrea, Mann-Ran, Christine, Raboso-Gallego, Javier, Alemán-Arteaga, Silvia, Buhles, Alexandra, Sterker, Dario, Sánchez, Elena G., Martínez-Cano, Jorge, Blanco, Oscar, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, García Criado, Francisco Javier, García Cenador, María Begoña, Radimerski, Thomas, Ramírez-Orellana, Manuel, Cobaleda, César, Yang, Jun J., Vicente-Dueñas, Carolina, Weiss, Andreas, Nichols, Kim E., Sánchez-García, Isidro
Publicado 2022

Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Im...

por Vega-García, Nerea, Perez-Jaume, Sara, Esperanza-Cebollada, Elena, Vicente-Garcés, Clara, Torrebadell, Montserrat, Jiménez-Velasco, Antonio, Ortega, Margarita, Llop, Marta, Abad, Lorea, Vagace, José Manuel, Minguela, Alfredo, Pratcorona, Marta, Sánchez-Garcia, Joaquín, García-Calderón, Clara B., Gómez-Casares, María Teresa, Martín-Clavero, Estela, Escudero, Adela, Riñón Martinez-Gallo, Marta, Muñoz, Luz, Velasco, María Rosario, García-Morin, Marina, Català, Albert, Pascual, Antonia, Velasco, Pablo, Fernández, José Mª., Lassaletta, Alvaro, Fuster, José Luis, Badell, Isabel, Molinos-Quintana, Águeda, Molinés, Antonio, Guerra-García, Pilar, Pérez-Martínez, Antonio, García-Abós, Miriam, Robles Ortiz, Reyes, Pisa, Sandra, Adán, Rosa, Díaz de Heredia, Cristina, Dapena, José Luis, Rives, Susana, Ramírez-Orellana, Manuel, Camós, Mireia
Publicado 2021