Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines

por Ramamurthy, Vidya P., Ramalingam, Senthilmurugan, Gediya, Lalji, Kwegyir-Afful, Andrew K., Njar, Vincent C.O.
Publicado 2014

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer...

por Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Purushottamachar, Puranik, Ramamurthy, Vidya P., Njar, Vincent C.O.
Publicado 2015

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer c...

por Ramalingam, Senthilmurugan, Gediya, Lalji, Kwegyir-Afful, Andrew K., Ramamurthy, Vidya P., Purushottamachar, Puranik, Mbatia, Hannah, Njar, Vincent C. O.
Publicado 2014

The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

por Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Gediya, Lalji K., Murigi, Francis N., Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A., Lapidus, Rena G., Njar, Vincent C. O.
Publicado 2019

Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In V...

por Kwegyir-Afful, Andrew K., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Purushottamachar, Puranik, Murigi, Francis N., Vasaitis, Tadas S., Huang, Weiliang, Kane, Maureen A., Zhang, Yuji, Ambulos, Nicholas, Tiwari, Sudhir, Srivastava, Pratima, Nnane, Ivo P., Hussain, Arif, Qiu, Yun, Weber, David J., Njar, Vincent C. O.
Publicado 2019