Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active...

por Bloks, Niek GC, Dicks, Amanda, Harissa, Zainab, Nelissen, Rob GHH, Hajmousa, Ghazaleh, Ramos, Yolande FM, Almeida, Rodrigo Coutinho, Guilak, Farshid, Meulenbelt, Ingrid
Publicado 2023

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers

por Ramos, Yolande F. M., Coutinho de Almeida, Rodrigo, Lakenberg, Nico, Suchiman, Eka, Mei, Hailiang, Kloppenburg, Margreet, Nelissen, Rob G. H. H., Meulenbelt, Ingrid
Publicado 2021

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis

por Coutinho de Almeida, Rodrigo, Tuerlings, Margo, Ramos, Yolande, Den Hollander, Wouter, Suchiman, Eka, Lakenberg, Nico, Nelissen, Rob G H H, Mei, Hailiang, Meulenbelt, Ingrid
Publicado 2022

The role of TNFRSF11B in development of osteoarthritic cartilage

por Rodríguez Ruiz, Alejandro, Tuerlings, Margo, Das, Ankita, Coutinho de Almeida, Rodrigo, Suchiman, H Eka D, Nelissen, Rob G H H, Ramos, Yolande F M, Meulenbelt, Ingrid
Publicado 2021

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

por Houtman, Evelyn, van Hoolwerff, Marcella, Lakenberg, Nico, Suchiman, Eka H. D., van der Linden-van der Zwaag, Enrike, Nelissen, Rob G. H. H., Ramos, Yolande F. M., Meulenbelt, Ingrid
Publicado 2021

Characterizing the secretome of licensed hiPSC-derived MSCs

por Ramos, Yolande F. M., Tertel, Tobias, Shaw, Georgina, Staubach, Simon, de Almeida, Rodrigo Coutinho, Suchiman, Eka, Kuipers, Thomas B., Mei, Hailiang, Barry, Frank, Murphy, Mary, Giebel, Bernd, Meulenbelt, Ingrid
Publicado 2022

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

por Bomer, Nils, Cornelis, Frederique M. F., Ramos, Yolande F. M., den Hollander, Wouter, Lakenberg, Nico, van der Breggen, Ruud, Storms, Lies, Slagboom, P. Eline, Lories, Rik J. U., Meulenbelt, Ingrid
Publicado 2016

Tissue-specific transcript annotation and expression profiling with complementary next-generation sequencing technologies

por Hestand, Matthew S., Klingenhoff, Andreas, Scherf, Matthias, Ariyurek, Yavuz, Ramos, Yolande, van Workum, Wilbert, Suzuki, Makoto, Werner, Thomas, van Ommen, Gert-Jan B., den Dunnen, Johan T., Harbers, Matthias, 't Hoen, Peter A.C.
Publicado 2010

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

por van Hoolwerff, Marcella, Rodríguez Ruiz, Alejandro, Bouma, Marga, Suchiman, H. Eka D., Koning, Roman I., Jost, Carolina R., Mulder, Aat A., Freund, Christian, Guilak, Farshid, Ramos, Yolande F. M., Meulenbelt, Ingrid
Publicado 2021

Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis

por Garcia de Vinuesa, Amaya, Sanchez‐Duffhues, Gonzalo, Blaney‐Davidson, Esmeralda, van Caam, Arjan, Lodder, Kirsten, Ramos, Yolande, Kloppenburg, Margreet, Meulenbelt, Ingrid, van der Kraan, Peter, Goumans, Marie‐José, ten Dijke, Peter
Publicado 2021

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation

por Ramos, Yolande F. M., Hestand, Matthew S., Verlaan, Matty, Krabbendam, Elise, Ariyurek, Yavuz, van Galen, Michiel, van Dam, Hans, van Ommen, Gert-Jan B., den Dunnen, Johan T., Zantema, Alt, ′t Hoen, Peter A. C.
Publicado 2010

Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells

por Rodríguez Ruiz, Alejandro, Dicks, Amanda, Tuerlings, Margo, Schepers, Koen, van Pel, Melissa, Nelissen, Rob G. H. H., Freund, Christian, Mummery, Christine L., Orlova, Valeria, Guilak, Farshid, Meulenbelt, Ingrid, Ramos, Yolande F. M.
Publicado 2021

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

por Houtman, Evelyn, Tuerlings, Margo, Riechelman, Janne, Suchiman, Eka H. E. D., van der Wal, Robert J. P., Nelissen, Rob G. H. H., Mei, Hailiang, Ramos, Yolande F. M., Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid
Publicado 2021

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

por Panoutsopoulou, Kalliope, Thiagarajah, Shankar, Zengini, Eleni, Day-Williams, Aaron G, Ramos, Yolande FM, Meessen, Jennifer MTA, Huetink, Kasper, Nelissen, Rob GHH, Southam, Lorraine, Rayner, N William, Doherty, Michael, Meulenbelt, Ingrid, Zeggini, Eleftheria, Wilkinson, J Mark
Publicado 2017

Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

por van Hoolwerff, Marcella, Metselaar, Paula I., Tuerlings, Margo, Suchiman, H. Eka D., Lakenberg, Nico, Ramos, Yolande F.M., Cats, Davy, Nelissen, Rob G.H.H., Broekhuis, Demiën, Mei, Hailiang, de Almeida, Rodrigo Coutinho, Meulenbelt, Ingrid
Publicado 2020

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

por Coutinho de Almeida, Rodrigo, Mahfouz, Ahmed, Mei, Hailiang, Houtman, Evelyn, den Hollander, Wouter, Soul, Jamie, Suchiman, Eka, Lakenberg, Nico, Meessen, Jennifer, Huetink, Kasper, Nelissen, Rob G H H, Ramos, Yolande F M, Reinders, Marcel, Meulenbelt, Ingrid
Publicado 2020

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis

por Tuerlings, Margo, van Hoolwerff, Marcella, van Bokkum, Jessica M, Suchiman, H Eka D, Lakenberg, Nico, Broekhuis, Demiën, Nelissen, Rob G H H, Ramos, Yolande F M, Mei, Hailiang, Cats, Davy, Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid
Publicado 2021

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study

por Ramos, Yolande F. M., den Hollander, Wouter, Bovée, Judith V. M. G., Bomer, Nils, van der Breggen, Ruud, Lakenberg, Nico, Keurentjes, J. Christiaan, Goeman, Jelle J., Slagboom, P. Eline, Nelissen, Rob G. H. H., Bos, Steffan D., Meulenbelt, Ingrid
Publicado 2014

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

por Rodríguez Ruiz, Alejandro, van Hoolwerff, Marcella, Sprangers, Sara, Suchiman, Eka, Schoenmaker, Ton, Dibbets-Schneider, Petra, Bloem, Johan L, Nelissen, Rob G H H, Freund, Christian, Mummery, Christine, Everts, Vincent, de Vries, Teun J, Ramos, Yolande F M, Meulenbelt, Ingrid
Publicado 2022

Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes

por Houtman, Evelyn, Tuerlings, Margo, Suchiman, H Eka D, Lakenberg, Nico, Cornelis, Frederique M F, Mei, Hailiang, Broekhuis, Demiën, Nelissen, Rob G H H, Coutinho de Almeida, Rodrigo, Ramos, Yolande F M, Lories, Rik J, Cruz, Luis J, Meulenbelt, Ingrid
Publicado 2022