A Primary Evaluation of Potential Small‐Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment

por Körschgen, Hagen, Jäger, Christian, Tan, Kathrin, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel
Publicado 2020

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

por Tan, Kathrin, Jäger, Christian, Geissler, Stefanie, Schlenzig, Dagmar, Buchholz, Mirko, Ramsbeck, Daniel
Publicado 2023

Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase

por Ramsbeck, Daniel, Taudte, Nadine, Jänckel, Nadine, Strich, Stefanie, Rahfeld, Jens-Ulrich, Buchholz, Mirko
Publicado 2021

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach

por Tan, Kathrin, Jäger, Christian, Körschgen, Hagen, Geissler, Stefanie, Schlenzig, Dagmar, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel
Publicado 2020

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

por Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Publicado 2021

A Diazirine‐Modified Membrane Lipid to Study Peptide/Lipid Interactions – Chances and Challenges

por Dorner, Julia, Korn, Patricia, Gruhle, Kai, Ramsbeck, Daniel, Garamus, Vasil M., Lilie, Hauke, Meister, Annette, Schwieger, Christian, Ihling, Christian, Sinz, Andrea, Drescher, Simon
Publicado 2021

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

por Bayly-Jones, Charles, Lupton, Christopher J., Fritz, Claudia, Venugopal, Hariprasad, Ramsbeck, Daniel, Wermann, Michael, Jäger, Christian, de Marco, Alex, Schilling, Stephan, Schlenzig, Dagmar, Whisstock, James C.
Publicado 2022

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis

por Taudte, Nadine, Linnert, Miriam, Rahfeld, Jens-Ulrich, Piechotta, Anke, Ramsbeck, Daniel, Buchholz, Mirko, Kolenko, Petr, Parthier, Christoph, Houston, John A., Veillard, Florian, Eick, Sigrun, Potempa, Jan, Schilling, Stephan, Demuth, Hans-Ulrich, Stubbs, Milton T.
Publicado 2021

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology

por Gnoth, Kathrin, Piechotta, Anke, Kleinschmidt, Martin, Konrath, Sandra, Schenk, Mathias, Taudte, Nadine, Ramsbeck, Daniel, Rieckmann, Vera, Geissler, Stefanie, Eichentopf, Rico, Barendrecht, Susan, Hartlage-Rübsamen, Maike, Demuth, Hans-Ulrich, Roßner, Steffen, Cynis, Holger, Rahfeld, Jens-Ulrich, Schilling, Stephan
Publicado 2020