A critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy

por Randáková, Alena, Nelic, Dominik, Jakubík, Jan
Publicado 2023

On homology modeling of the M(2) muscarinic acetylcholine receptor subtype

por Jakubík, Jan, Randáková, Alena, Doležal, Vladimír
Publicado 2013

Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors

por Jakubík, Jan, Randáková, Alena, El-Fakahany, Esam E, Doležal, Vladimír
Publicado 2009

Novel long‐acting antagonists of muscarinic ACh receptors

por Randáková, Alena, Rudajev, Vladimír, Doležal, Vladimír, Boulos, John, Jakubík, Jan
Publicado 2018

Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators

por Jakubík, Jan, Randáková, Alena, El-Fakahany, Esam E., Doležal, Vladimír
Publicado 2019

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

por Szczurowska, Ewa, Szánti-Pintér, Eszter, Randáková, Alena, Jakubík, Jan, Kudova, Eva
Publicado 2022

Subtype Differences in Pre-Coupling of Muscarinic Acetylcholine Receptors

por Jakubík, Jan, Janíčková, Helena, Randáková, Alena, El-Fakahany, Esam E., Doležal, Vladimír
Publicado 2011

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

por Jakubík, Jan, Randáková, Alena, Zimčík, Pavel, El-Fakahany, Esam E., Doležal, Vladimír
Publicado 2017

The operational model of allosteric modulation of pharmacological agonism

por Jakubík, Jan, Randáková, Alena, Chetverikov, Nikolai, El-Fakahany, Esam E., Doležal, Vladimír
Publicado 2020

Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids

por Szczurowska, Ewa, Szánti-Pintér, Eszter, Chetverikov, Nikolai, Randáková, Alena, Kudová, Eva, Jakubík, Jan
Publicado 2022

Applications and limitations of fitting of the operational model to determine relative efficacies of agonists

por Jakubík, Jan, Randáková, Alena, Rudajev, Vladimír, Zimčík, Pavel, El-Fakahany, Esam E., Doležal, Vladimír
Publicado 2019

Fusion with Promiscuous Gα(16) Subunit Reveals Signaling Bias at Muscarinic Receptors

por Randáková, Alena, Nelic, Dominik, Hochmalová, Martina, Zimčík, Pavel, Mulenga, Mutale Jane, Boulos, John, Jakubík, Jan
Publicado 2021

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D(2) 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole

por Juza, Radomir, Stefkova, Kristyna, Dehaen, Wim, Randakova, Alena, Petrasek, Tomas, Vojtechova, Iveta, Kobrlova, Tereza, Pulkrabkova, Lenka, Muckova, Lubica, Mecava, Marko, Prchal, Lukas, Mezeiova, Eva, Musilek, Kamil, Soukup, Ondrej, Korabecny, Jan
Publicado 2021