MamA essentiality in Mycobacterium smegmatis is explained by the presence of an apparent cognate restriction endonuclease

por Randall, Samantha E., Martini, Maria Carla, Zhou, Ying, Joubran, Samantha R., Shell, Scarlet S.
Publicado 2020

Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

por Leventhal, Shanna S., Meade-White, Kimberly, Rao, Deepashri, Haddock, Elaine, Leung, Jacqueline, Scott, Dana, Archer, Jacob, Randall, Samantha, Erasmus, Jesse H., Feldmann, Heinz, Hawman, David W.
Publicado 2022

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

por Hawman, David W., Meade-White, Kimberly, Archer, Jacob, Leventhal, Shanna, Wilson, Drew, Shaia, Carl, Randall, Samantha, Khandhar, Amit P., Hsiang, Tien-Ying, Gale, Michael, Berglund, Peter, Fuller, Deborah Heydenburg, Feldmann, Heinz, Erasmus, Jesse H.
Publicado 2021

A Single Dose SARS-CoV-2 Replicon RNA Vaccine Induces Cellular and Humoral Immune Responses in Simian Immunodeficiency Virus Infected and Uninfected Pigtail Macaques

por O’Connor, Megan A., Erasmus, Jesse H., Randall, Samantha, Archer, Jacob, Lewis, Thomas B., Brown, Brieann, Fredericks, Megan, Groenier, Skyler, Iwayama, Naoto, Ahrens, Chul, Garrison, William, Wangari, Solomon, Guerriero, Kathryn A., Fuller, Deborah H.
Publicado 2021

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

por Hawman, David W, Meade-White, Kimberly, Archer, Jacob, Leventhal, Shanna S, Wilson, Drew, Shaia, Carl, Randall, Samantha, Khandhar, Amit P, Krieger, Kyle, Hsiang, Tien-Ying, Gale, Michael, Berglund, Peter, Fuller, Deborah Heydenburg, Feldmann, Heinz, Erasmus, Jesse H
Publicado 2022

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

por Hawman, David W., Meade-White, Kimberly, Clancy, Chad, Archer, Jacob, Hinkley, Troy, Leventhal, Shanna S., Rao, Deepashri, Stamper, Allie, Lewis, Matthew, Rosenke, Rebecca, Krieger, Kyle, Randall, Samantha, Khandhar, Amit P., Hao, Linhue, Hsiang, Tien-Ying, Greninger, Alexander L., Gale, Michael, Berglund, Peter, Fuller, Deborah Heydenburg, Rosenke, Kyle, Feldmann, Heinz, Erasmus, Jesse H.
Publicado 2022

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

por Erasmus, Jesse H., Khandhar, Amit P., Walls, Alexandra C., Hemann, Emily A., O’Connor, Megan A., Murapa, Patience, Archer, Jacob, Leventhal, Shanna, Fuller, Jim, Lewis, Thomas, Draves, Kevin E., Randall, Samantha, Guerriero, Kathryn A., Duthie, Malcolm S., Carter, Darrick, Reed, Steven G., Hawman, David W., Feldmann, Heinz, Gale, Michael, Veesler, David, Berglund, Peter, Fuller, Deborah Heydenburg
Publicado 2020

An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

por Erasmus, Jesse H., Khandhar, Amit P., O’Connor, Megan A., Walls, Alexandra C., Hemann, Emily A., Murapa, Patience, Archer, Jacob, Leventhal, Shanna, Fuller, James T., Lewis, Thomas B., Draves, Kevin E., Randall, Samantha, Guerriero, Kathryn A., Duthie, Malcolm S., Carter, Darrick, Reed, Steven G., Hawman, David W., Feldmann, Heinz, Gale, Michael, Veesler, David, Berglund, Peter, Heydenburg Fuller, Deborah
Publicado 2020

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

por O’Connor, Megan A., Hawman, David W., Meade-White, Kimberly, Leventhal, Shanna, Song, Wenjun, Randall, Samantha, Archer, Jacob, Lewis, Thomas B., Brown, Brieann, Fredericks, Megan N., Sprouse, Kaitlin R., Tunggal, Hillary C., Maughan, Mara, Iwayama, Naoto, Ahrens, Chul, Garrison, William, Wangari, Solomon, Guerriero, Kathryn A., Hanley, Patrick, Lovaglio, Jamie, Saturday, Greg, Veesler, David, Edlefsen, Paul T., Khandhar, Amit P., Feldmann, Heinz, Fuller, Deborah Heydenburg, Erasmus, Jesse H.
Publicado 2023