Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs

por Northup, John K., Jian, Xiaoying, Randazzo, Paul A.
Publicado 2012

ACAP-A/B Are ArfGAP Homologs in Dictyostelium Involved in Sporulation but Not in Chemotaxis

por Chen, Pei-Wen, Randazzo, Paul A., Parent, Carole A.
Publicado 2010

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

por Rosenfeldt, Hans, Castellone, Maria Domenica, Randazzo, Paul A, Gutkind, J Silvio
Publicado 2006

The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain

por Gasilina, Anjelika, Vitali, Teresa, Luo, Ruibai, Jian, Xiaoying, Randazzo, Paul A.
Publicado 2019

A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments

por Gasilina, Anjelika, Yoon, Hye-Young, Jian, Xiaoying, Luo, Ruibai, Randazzo, Paul A.
Publicado 2022

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes

por Randazzo, Paul A, Jian, Xiaoying, Chen, Pei-Wen, Zhai, Peng, Soubias, Olivier, Northup, John K
Publicado 2014

ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat

por Yang, Jia-Shu, Lee, Stella Y., Gao, Minggeng, Bourgoin, Sylvain, Randazzo, Paul A., Premont, Richard T., Hsu, Victor W.
Publicado 2002

In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells

por Wada, Junya, Rathnayake, Udumbara, Jenkins, Lisa M., Singh, Avinash, Mohammadi, Moosa, Appella, Ettore, Randazzo, Paul A., Samelson, Lawrence E.
Publicado 2022

Acaps Are Arf6 Gtpase-Activating Proteins That Function in the Cell Periphery

por Jackson, Trevor R., Brown, Fraser D., Nie, Zhongzhen, Miura, Koichi, Foroni, Letizia, Sun, Jianlan, Hsu, Victor W., Donaldson, Julie G., Randazzo, Paul A.
Publicado 2000

A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin

por Esteban, Pedro F., Yoon, Hye-Young, Becker, Jodi, Dorsey, Susan G., Caprari, Paola, Palko, Mary Ellen, Coppola, Vincenzo, Saragovi, H. Uri, Randazzo, Paul A., Tessarollo, Lino
Publicado 2006

Consensus nomenclature for the human ArfGAP domain-containing proteins

por Kahn, Richard A., Bruford, Elspeth, Inoue, Hiroki, Logsdon, John M., Nie, Zhongzhen, Premont, Richard T., Randazzo, Paul A., Satake, Masanobu, Theibert, Anne B., Zapp, Maria L., Cassel, Dan
Publicado 2008

Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1

por Soubias, Olivier, Pant, Shashank, Heinrich, Frank, Zhang, Yue, Roy, Neeladri Sekhar, Li, Jess, Jian, Xiaoying, Yohe, Marielle E., Randazzo, Paul A., Lösche, Mathias, Tajkhorshid, Emad, Byrd, R. Andrew
Publicado 2020

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

por Sethna, Saumil, Scott, Patrick A., Giese, Arnaud P. J., Duncan, Todd, Jian, Xiaoying, Riazuddin, Sheikh, Randazzo, Paul A., Redmond, T. Michael, Bernstein, Steven L., Riazuddin, Saima, Ahmed, Zubair M.
Publicado 2021

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1

por Zhang, Yue, Soubias, Olivier, Pant, Shashank, Heinrich, Frank, Vogel, Alexander, Li, Jess, Li, Yifei, Clifton, Luke A., Daum, Sebastian, Bacia, Kirsten, Huster, Daniel, Randazzo, Paul A., Lösche, Mathias, Tajkhorshid, Emad, Byrd, R. Andrew
Publicado 2023

ARF GTPases and their GEFs and GAPs: concepts and challenges

por Sztul, Elizabeth, Chen, Pei-Wen, Casanova, James E., Cherfils, Jacqueline, Dacks, Joel B., Lambright, David G., Lee, Fang-Jen S., Randazzo, Paul A., Santy, Lorraine C., Schürmann, Annette, Wilhelmi, Ilka, Yohe, Marielle E., Kahn, Richard A.
Publicado 2019

The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins

por Rosenberg, Eric M., Jian, Xiaoying, Soubias, Olivier, Yoon, Hye-Young, Yadav, Mukesh P., Hammoudeh, Sarah, Pallikkuth, Sandeep, Akpan, Itoro, Chen, Pei-Wen, Maity, Tapan K., Jenkins, Lisa M., Yohe, Marielle E., Byrd, R. Andrew, Randazzo, Paul A.
Publicado 2023