Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

por Jenkins, Meredith L., Ranga-Prasad, Harish, Parson, Matthew A. H., Harris, Noah J., Rathinaswamy, Manoj K., Burke, John E.
Publicado 2023

Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

por Setua, Sonali, Enguita, Francisco J., Chora, Ângelo Ferreira, Ranga-prasad, Harish, Lahree, Aparajita, Marques, Sofia, Sundaramurthy, Varadharajan, Mota, Maria M.
Publicado 2020

Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development

por Balasubramanian, Lakshmi, Zuzarte-Luís, Vanessa, Syed, Tabish, Mullick, Debakshi, Deb, Saptarathi, Ranga-Prasad, Harish, Meissner, Jana, Almeida, Ana, Furstenhaupt, Tobias, Siddiqi, Kaleem, Prudêncio, Miguel, Rodrigues, Cecilia M. P., Mota, Maria, Sundaramurthy, Varadharajan
Publicado 2020

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

por Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew AH, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheekey, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Publicado 2023

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

por Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew AH, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheeky, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Publicado 2023

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

por Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.
Publicado 2023