Clinical development innovation in rare diseases: overcoming barriers to successful delivery of a randomised clinical trial in alkaptonuria—a mini-review

por Ranganath, L. R., Sireau, Nick
Publicado 2023

Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria – Is nitisinone the solution?

por Davison, A.S., Luangrath, E., Selvi, E., Ranganath, L.R.
Publicado 2020

Treatment of osteoporotic fractures in alkaptonuria by teriparatide stimulates bone formation and decreases fracture rate – A report of two cases

por Ranganath, L.R., Khedr, M., Mistry, A., Vinjamuri, S., Gallagher, J.A.
Publicado 2021

A case report of pregnancy in untreated alkaptonuria – Focus on urinary tissue remodelling markers

por Ranganath, L.R., Milan, A.M., Bay-Jensen, A.C., Thudium, C.S.
Publicado 2021

Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria

por Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Rovensky, J., Psarelli, E. E., Cox, T. F., Rhodes, N. P., Gallagher, J. A., Ranganath, L. R.
Publicado 2019

Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging

por Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., Milan, A. M., Goodwin, R. J. A., Ranganath, L. R., Gallagher, J. A.
Publicado 2019

Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectromet...

por Davison, Andrew S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., Milan, A. M., Goodwin, R. J. A., Ranganath, L. R., Gallagher, J. A.
Publicado 2019

Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria

por Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., M, Khedr, Norman, B. P., Bou-Gharios, G., Gallagher, J. A., Imrich, R., Arnoux, J. B., Rudebeck, M., Olsson, B.
Publicado 2022

Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria

por Ranganath, L.R., Milan, A.M., Hughes, A.T., Davison, A.S., Khedr, M., Norman, B.P., Bou-Gharios, G., Gallagher, J.A., Gornall, M., Jackson, R., Imrich, R., Rovensky, J., Rudebeck, M., Olsson, B.
Publicado 2022

Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone

por Griffin, R., Psarelli, E.E., Cox, T.F., Khedr, M., Milan, A.M., Davison, A.S., Hughes, A.T., Usher, J.L., Taylor, S., Loftus, N., Daroszewska, A., West, E., Jones, A., Briggs, M., Fisher, M., McCormick, M., Judd, S., Vinjamuri, S., Sireau, N., Dillon, J.P., Devine, J.M., Hughes, G., Harrold, J., Barton, G.J., Jarvis, J.C., Gallagher, J.A., Ranganath, L.R.
Publicado 2018