DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

por Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Publicado 2019

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

por Griswold, Andrew R., Ball, Daniel P., Bhattacharjee, Abir, Chui, Ashley J., Rao, Sahana D., Taabazuing, Cornelius Y., Bachovchin, Daniel A.
Publicado 2019

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

por Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Publicado 2020

Activation of the CARD8 Inflammasome Requires a Disordered Region

por Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.
Publicado 2020

Caspase-1 interdomain linker cleavage is required for pyroptosis

por Ball, Daniel P, Taabazuing, Cornelius Y, Griswold, Andrew R, Orth, Elizabeth L, Rao, Sahana D, Kotliar, Ilana B, Vostal, Lauren E, Johnson, Darren C, Bachovchin, Daniel A
Publicado 2020

DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

por Johnson, Darren C., Taabazuing, Cornelius Y., Okondo, Marian C., Chui, Ashley J., Rao, Sahana D., Brown, Fiona C., Reed, Casie, Peguero, Elizabeth, de Stanchina, Elisa, Kentsis, Alex, Bachovchin, Daniel A.
Publicado 2018