Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

por Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Publicado 2018

Allostery governs Cdk2 activation and differential recognition of CDK inhibitors

por Majumdar, Abir, Burban, David J., Muretta, Joseph M., Thompson, Andrew R., Engel, Tiffany A., Rasmussen, Damien M., Subrahmanian, Manu V., Veglia, Gianluigi, Thomas, David D., Levinson, Nicholas M.
Publicado 2021

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

por Faber, Erik B., Sun, Luxin, Tang, Jian, Roberts, Emily, Ganeshkumar, Sornakala, Wang, Nan, Rasmussen, Damien, Majumdar, Abir, Hirsch, Laura E., John, Kristen, Yang, An, Khalid, Hira, Hawkinson, Jon E., Levinson, Nicholas M., Chennathukuzhi, Vargheese, Harki, Daniel A., Schönbrunn, Ernst, Georg, Gunda I.
Publicado 2023