Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use

por Abbotts, Rachel, Dellomo, Anna J., Rassool, Feyruz V.
Publicado 2022

LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells

por Pan, Li, Chen, Xiang, Rassool, Feyruz Virgilia, Li, Chenglong, Lin, Jiayuh
Publicado 2022

High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

por Nagaria, Pratik K., Robert, Carine, Park, Tea Soon, Huo, Jeffrey S., Zambidis, Elias T., Rassool, Feyruz V.
Publicado 2016

PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers

por Dellomo, Anna J., Abbotts, Rachel, Eberly, Christian L., Karbowski, Mariusz, Baer, Maria R., Kingsbury, Tami J., Rassool, Feyruz V.
Publicado 2021

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

por Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Publicado 2016

Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells

por Fan, Lingling, Xu, Songhui, Zhang, Fengbo, Cui, Xiaolu, Fazli, Ladan, Gleave, Martin, Clark, David J., Yang, Austin, Hussain, Arif, Rassool, Feyruz, Qi, Jianfei
Publicado 2020

Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR

por Puts, Gemma, Jarrett, Stuart, Leonard, Mary, Matsangos, Nicolette, Snyder, Devin, Wang, Ying, Vincent, Richard, Portney, Benjamin, Abbotts, Rachel, McLaughlin, Lena, Zalzman, Michal, Rassool, Feyruz, Kaetzel, David
Publicado 2020

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 inter...

por Scarpa, Mario, Kapoor, Shivani, Tvedte, Eric S., Doshi, Kshama A., Zou, Ying S., Singh, Prerna, Lee, Jonelle K., Chatterjee, Aditi, Ali, Moaath K. Mustafa, Bromley, Robin E., Hotopp, Julie C. Dunning, Rassool, Feyruz V., Baer, Maria R.
Publicado 2021

Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia

por Kogan, Aksinija A., Topper, Michael J., Dellomo, Anna J., Stojanovic, Lora, McLaughlin, Lena J., Creed, T. Michael, Eberly, Christian L., Kingsbury, Tami J., Baer, Maria R., Kessler, Michael D., Baylin, Stephen B., Rassool, Feyruz V.
Publicado 2022

Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Re...

por Lapidus, Rena G., Carter-Cooper, Brandon A., Sadowska, Mariola, Choi, Eun Yong, Wonodi, Omasiri, Muvarak, Nidal, Natarajan, Karthika, Pidugu, Lakshmi S., Jaiswal, Anil, Toth, Eric A., Rassool, Feyruz V., Etemadi, Arash, Sausville, Edward A., Baer, Maria R., Emadi, Ashkan
Publicado 2016